A5023439220- Hormonal Regulation and Hypertension
- Economic and Financial Impacts of Cancer
- Colorectal Cancer Treatments and Studies
- Cancer, Hypoxia, and Metabolism
- Eicosanoids and Hypertension Pharmacology
- BRCA gene mutations in cancer
- Cancer Research and Treatments
- Estrogen and related hormone effects
- Synthesis of Tetrazole Derivatives
- Melanoma and MAPK Pathways
- Cancer, Stress, Anesthesia, and Immune Response
- Glutathione Transferases and Polymorphisms
- Ethics in Clinical Research
- Protein Kinase Regulation and GTPase Signaling
- Vitamin C and Antioxidants Research
- HIV, Drug Use, Sexual Risk
- Science, Research, and Medicine
- Patient-Provider Communication in Healthcare
- Breastfeeding Practices and Influences
- Child and Adolescent Health
- Opioid Use Disorder Treatment
- Biomedical and Engineering Education
- Genomics, phytochemicals, and oxidative stress
- Mitochondrial Function and Pathology
- Advances in Oncology and Radiotherapy
Horizons Clinical Research Center
2024
University of Glasgow
2018
University of North Carolina at Chapel Hill
2015-2016
Public Health Department
2016
Abstract Exploiting oxidative stress has recently emerged as a plausible strategy for treatment of human cancer, and antioxidant defenses are implicated in resistance to chemotherapy radiotherapy. Targeted suppression could thus broadly improve therapeutic outcomes. Here, we identify the AMPK-related kinase NUAK1 key component response pathway reveal specific requirement this role colorectal cancer. We show that is activated by activation required facilitate nuclear import master regulator...
Activating mutations of Ras are one the most prevalent drivers cancer and often associated with poor clinical outcomes. Despite FDA approval for two irreversible inhibitors that target inactive state KRasG12C, significant unmet need still exists, susceptibility non-G12C mutants to inactive-state inhibition remains unclear. Here we report discovery a novel series reversible bind in an enlarged version switch I-II pocket nanomolar affinities. Dependent on chemotype these can either...
Oncotype DX (ODX), a tumor gene profiling test, has been incorporated into clinical guidelines to aid in adjuvant chemotherapy decision making for early-stage, hormone receptor positive breast cancer patients. Despite United States (U.S.) guidelines, less than half of eligible women receive testing. Reasons low usage are unclear: Our objective was better understand U.S. oncologists' ODX uptake and how they use during making.We conducted semi-structured, ~30-minute phone interviews with...
Oncotype DX testing (ODX), a tumor gene expression test, may improve breast cancer care, however, communicating results remains challenging. We identified patient-centered communication strategies/gaps for discussing ODX results. applied framework to analyze qualitative interviews with oncologists about how they communicate patients, using template analysis in Atlas.ti. Overall, providers discussed four domains: exchanging information, assessing uncertainty, making decisions and...
Activating mutations of Ras are one the most prevalent drivers cancer and often associated with poor clinical outcomes. Despite FDA approval for two irreversible inhibitors that target inactive state KRasG12C, significant unmet need still exists, susceptibility non-G12C mutants to inactive-state inhibition remains unclear. Here we report discovery a novel series reversible bind in an enlarged version switch I-II pocket nanomolar affinities. Dependent on chemotype these can either...
Activating mutations of Ras are one the most prevalent drivers cancer and often associated with poor clinical outcomes. Despite FDA approval for two irreversible inhibitors that target inactive state KRasG12C, significant unmet need still exists, susceptibility non-G12C mutants to inactive-state inhibition remains unclear. Here we report discovery a novel series reversible bind in an enlarged version switch I-II pocket nanomolar affinities. Dependent on chemotype these can either...
<h3>Statement of purpose</h3> Over 1,000 people each year die from drug overdose in North Carolina. Naloxone can effectively reverse an opioid overdose. Community access to naloxone has increasingly become a standard prevention strategy. In 2013, Carolina passed Good Samaritan/Naloxone Access law intended increase by those at risk, community, and family members. The use standing orders for among Local Health Departments (LHDs) may be effective distribution mechanism the state. However, date,...
<p>Merged supplementary Figures & Figure legends and Tables Table legends</p>
<p>Supplementary Methods</p>
<p>Merged supplementary Figures & Figure legends and Tables Table legends</p>
<p>Supplementary Methods</p>
<div>Abstract<p>Exploiting oxidative stress has recently emerged as a plausible strategy for treatment of human cancer, and antioxidant defenses are implicated in resistance to chemotherapy radiotherapy. Targeted suppression could thus broadly improve therapeutic outcomes. Here, we identify the AMPK-related kinase NUAK1 key component response pathway reveal specific requirement this role colorectal cancer. We show that is activated by activation required facilitate nuclear import...
<div>Abstract<p>Exploiting oxidative stress has recently emerged as a plausible strategy for treatment of human cancer, and antioxidant defenses are implicated in resistance to chemotherapy radiotherapy. Targeted suppression could thus broadly improve therapeutic outcomes. Here, we identify the AMPK-related kinase NUAK1 key component response pathway reveal specific requirement this role colorectal cancer. We show that is activated by activation required facilitate nuclear import...