Abstract Glaucoma poses a growing health challenge projected to escalate in the coming decades. However, current automated diagnostic approaches on diagnosis solely rely black-box deep learning models, lacking explainability and trustworthiness. To address issue, this study uses optical coherence tomography (OCT) images develop an explainable artificial intelligence (XAI) tool for diagnosing staging glaucoma, with focus its clinical applicability. A total of 334 normal 268 glaucomatous eyes...

Abstract Glaucoma is characterised by progressive vision loss due to retinal ganglion cell deterioration, leading gradual visual field (VF) impairment. The standard VF test may be impractical in some cases, where optical coherence tomography (OCT) can offer predictive insights into for multimodal diagnoses. However, predicting measures from OCT data remains challenging. To address this, five regression models were developed predict OCT, Shapley Additive exPlanations (SHAP) analysis was...

Henrietta Wangab & Michael Kalloniatisab* a Centre for Eye Health, Sydney, Australiab School of Optometry and Vision Science, University New South Wales, Australia

Abstract Purpose Large language models have shown promise in answering questions related to medical conditions. This study evaluated the responses of ChatGPT-4 patient-centred frequently asked (FAQs) relevant age-related macular degeneration (AMD). Methods Ten experts across a range clinical, education and research practices optometry ophthalmology. Over 200 patient-centric FAQs from authoritative professional society, hospital advocacy websites were condensed into 37 four themes:...

Abstract Purpose To examine the diagnostic accuracy of performing two (frontloaded) versus one (clinical standard) visual field (VF) test per visit for detecting progression early glaucoma in data derived from clinical populations. Methods A computer simulation model was used to follow VFs 10,000 patients (derived cohorts: Heijl et al., Swedish cohort; and Chauhan Canadian Glaucoma Study [CGS]) over a 10‐year period identify whose mean deviation (MD) detected. Core (baseline MD rates) were...

Clinical imaging provided by optical coherence tomography (OCT) and its variant, OCT-angiography (OCT-A), has revolutionised eyecare practice. The techniques allow for the identification quantification of ocular structures, supporting diagnosis prognosis eye disease. In this review, an overview usefulness OCT-A in management a range conditions is when used isolation or combination with other modalities measures visual function (visual field results). capacity to identify quantify vasculature...

In our intermediate-tier glaucoma care clinic, we demonstrate fair to moderate agreement in gonioscopy examination between optometrists and ophthalmologists, but excellent when considering open versus closed angles. We highlight the need for increased consistency evaluation recording of angle status using gonioscopy.The results obtained by different clinicians is not known important moving toward practice modalities such as telemedicine collaborative clinics. The purpose this study was...

Abstract Purpose To compare clinical visual field outputs in glaucoma and healthy patients returned by the Humphrey Field Analyzer (HFA) virtual reality (Virtual Field, VF) perimetry. Methods One eye of 54 41 subjects was prospectively tested (three times each random order) using HFA VF perimeters (24‐2 test grids). We extracted compared global indices (mean deviation [MD] pattern standard [PSD]), pointwise sensitivity (and calculated ‘equivalent’ after accounting for differences background...

Drusen are associated with retinal thinning in age-related macular degeneration (AMD). These changes, however, have mostly been examined at single time points, ignoring the evolution of drusen from emergence to regression. Understanding full breadth changes will improve understanding disease pathogenesis.The purpose this study was assess how natural history affects thickness, focusing on photoreceptor and pigment epithelium (RPE) layers.Spectral domain optical coherence tomography subjects...

To evaluate the agreement and accuracy of grading goniophotographs anterior segment optical coherence tomography (AS-OCT) results for assessment chamber angle, elicit factors driving concordance between perceived grade ground truth.Three clinicians evaluated AS-OCT 75 patients. Graders' impressions angle grade, trabecular pigmentation, iris contour were compared with truth gonioscopic examination result when physically performed by a senior optometrist. Percentage kappa statistics...

Purpose: We tested the hypothesis that clinical statokinetic dissociation (SKD, defined as difference in sensitivity to static and kinetic stimuli) at scotoma border retinal disease is due individual criterion bias SKD can be eliminated by equating psychophysical procedures for testing stimulus detection. Methods: Six subjects with glaucoma six retinitis pigmentosa (RP) were tested. Clinical (standard automated perimetry [SAP] manual [MKP]) used determine region of interest laboratory-based...

Technologies such as optical coherence tomography have facilitated the visualization of anatomical tissues that retina. The availability in vivo retinal data has led to hypothesis it may be able accurately predict visual function from information. However, accurate determination structure-function relationship remained elusive part due contributions non-retinal sources variability, thus imposing potential limitations fidelity relationship. Furthermore, differences manifestation functional...

SIGNIFICANCE We demonstrate that the visual field defects in patients with tilted disc syndrome can be reduced or eliminated by neutralizing peripheral scotoma area of posterior retinal bowing, which may allow differentiation between a congenital anomaly and acquired pathology. PURPOSE Tilted is unchanging condition present mimicking loss seen neurological diseases, such as transsynaptic retrograde degeneration. Our purpose was to systematically investigate ability neutralized refraction...

The imaging characteristics of congenital grouped pigmentation the retinal pigment epithelium (CGP-RPE) and its non-pigmented variant - albinotic epithelial spots (GCARPES) are poorly defined in literature. Our case series reports their multimodal across a spectrum presentations.A retrospective review patient records was conducted on patients seen at Centre for Eye Health between January December 2016. findings four cases is described using optical coherence tomography (OCT), infrared...

Clinical relevance: The existing notion that topical latanoprost can lead to symptoms of headaches by reporting three cases headache developed following instillation prescribed as first-line therapy for newly diagnosed primary open-angle glaucoma (POAG) is explored in this case series.Background: Prostaglandin analogues (PGAs) are often used treatment the POAG. An uncommon and infrequently reported side effect PGAs headaches.Methods: A retrospective review patient records was conducted on...

Abstract Current tests for assessing metamorphopsia do not account confounders such as perceptual filling-in and spatial redundancy, which affect its sensitivity repeatability. This proof-of-concept study aimed to assess the performance of a novel laboratory-based psychophysical test (Line Sag Test, LST) addresses these issues quantification in idiopathic epiretinal membranes. The LST quantifies perpendicular at three eccentricities (3°, 6°, 9°) along eight meridians (45° steps)....

Objectives Hyper-reflective outer retinal band (HORB) disruptions are reported across a range of disease, yet reliable, easily implemented assessment method and thorough evaluation their association to disease is lacking. The purpose the study was assess reliability using magnitude estimation evaluate HORB length determine its visual acuity disease. Design Cross-sectional, retrospective study. Setting Patients attending secondary eye care clinic in Sydney, Australia. Participants 2039 unique...