A5040759446- Global Public Health Policies and Epidemiology
- Prostate Cancer Treatment and Research
- PARP inhibition in cancer therapy
- Radiopharmaceutical Chemistry and Applications
- Obesity, Physical Activity, Diet
- Healthcare Systems and Reforms
- Global Health Care Issues
- Smoking Behavior and Cessation
- Child Nutrition and Water Access
- Research studies in Vietnam
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- DNA Repair Mechanisms
- COVID-19 and Mental Health
- Cardiovascular Health and Disease Prevention
- Dermatological and COVID-19 studies
- Oral Health Pathology and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Global Maternal and Child Health
- Salivary Gland Disorders and Functions
- Dermatology and Skin Diseases
- Sexuality, Behavior, and Technology
- Multiple Myeloma Research and Treatments
- Obesity and Health Practices
Janssen (United States)
2015-2025
Centre for Global Health Research
2018-2024
University of Toronto
2018-2024
RTI International
2023-2024
University of North Carolina at Chapel Hill
2024
Janssen Scientific Affairs (United States)
2022
National Taipei University of Nursing and Health Science
2022
St. Michael's Hospital
2018-2020
St Michaels Hospital
2019-2020
University of Waterloo
2018-2019
Metastatic castration-resistant prostate cancer (mCRPC) remains a lethal disease with current standard-of-care therapies. Homologous recombination repair (HRR) gene alterations, including
12 Background: Approximately 20% of mCRPC has alterations in genes associated with HRR and is responsive to PARP inhibitors (PARPi) such as NIRA. Combined PARPi androgen receptor pathway targeting may also benefit unselected mCRPC. MAGNITUDE assessed whether adding NIRA AAP improves outcomes pts or without genes. Methods: (NCT03748641) a randomized, double-blind phase 3 study. In eligible pts, ≤4 mos prior for was allowed. Pts (HRR biomarker [BM]+; ATM, BRCA1, BRCA2, BRIP1, CDK12, CHEK2,...
Patients with metastatic castration-resistant prostate cancer (mCRPC) and BRCA alterations have poor outcomes. MAGNITUDE found patients homologous recombination repair gene (HRR+), particularly BRCA1/2, benefit from first-line therapy niraparib plus abiraterone acetate prednisone (AAP). Here we report longer follow-up the second prespecified interim analysis (IA2).
Abstract Smoking globally kills over half of long-term smokers and causes about 7 million annual deaths. The World Health Organization Framework Convention for Tobacco Control (FCTC) is the main global policy strategy to combat smoking, but its effectiveness uncertain. Our interrupted time series analyses compared before- after-FCTC trends in numbers prevalence below age 25 years (when smoking initiation occurs during which response interventions greatest) on cessation at 45–59 quitting...
The incidence of infection during SARS-CoV-2 viral waves, the factors associated with infection, and durability antibody responses to among Canadian adults remain undocumented.
170 Background: In the primary analysis of phase 3 MAGNITUDE study, NIRA/AAP significantly improved outcomes in pts with mCRPC and HRR gene alterations. Here, we report results from IA2 secondary endpoints MAGNITUDE. Methods: 423 eligible alterations (HRR+ cohort) were randomized 1:1 to receive (n = 212) or placebo (PBO)/AAP 211). At prespecified IA2, (time cytotoxic chemotherapy [TCC], time symptomatic progression [TSP], overall survival [OS]) formally assessed rPFS endpoint was updated...
Plain Language SummaryWhat is this summary about?This a of the MAGNITUDE clinical study that was published in Journal Clinical Oncology (March 2023) and Annals (September 2023).Researchers looked at combination niraparib abiraterone acetate with prednisone as first treatment for adult patients metastatic castration-resistant prostate cancer.Researchers wanted to know how effective safe + whose cancers had certain gene changes. Researchers focused on genes related homologous recombination...
Random population-based surveys to estimate prevalence of SARS-CoV2 infection causing coronavirus disease (COVID-19) are useful understand distributions and predictors the infection. In April 2020, first-ever nationally representative survey in Canada polled 4,240 adults age 18 years older about self-reported COVID experience March, early epidemic. We examined levels symptoms, defined as fever plus difficulty breathing/shortness breath, dry cough so severe that it disrupts sleep, and/or loss...
BackgroundThe rapid increase in child and adolescent overweight obesity (OAO) China has a significant health economic impact. This study undertook an investment case analysis to evaluate the impacts of OAO potential returns from implementing specific policies interventions.MethodsThe estimates reduction mortality morbidity set evidence-based interventions across between 2025 2092 using deterministic Markov cohort model. Modelled were identified by literature review expert recommendation...
105 Background: MAGNITUDE, an international phase 3 randomized double-blind study, demonstrated that mCRPC pts with BRCA1/2 alterations receiving NIRA + AAP had significantly improved radiographic progression-free survival, and clinically relevant prolongations in time to symptomatic progression cytotoxic chemotherapy compared placebo (PBO) AAP. Here, we report PRO results (pain, health-related quality of life [HRQoL], side effect bother) the subset final analysis MAGNITUDE. Methods: Pts...
9 Background: As mCRPC is driven by activated androgen receptors and elevated intratumoral androgens, annihilation may require dual inhibition. APA AA are approved prostate cancer therapies that have distinct receptor inhibition ligand suppression actions, respectively. ACIS compared radiographic progression-free survival (rPFS) of + AAP vs PBO in chemo-naive mCRPC. Methods: pts with ongoing deprivation therapy (ADT) but no other life-prolonging treatment since diagnosis were randomized 1:1...
Several studies have shown the beneficial effects of tobacco fiscal policy, but distributional been less examined, especially at subnational level. The objective this study is to analyse a one-peso tax increase (roughly equivalent tripling current excise tax) on health, poverty, and financial outcomes level in Mexico.
172 Background: NIRA/AAP significantly improved outcomes in pts with mCRPC and HRR gene alterations, particularly BRCA, the phase 3 MAGNITUDE study. As a practical measure, were permitted to receive up 4 mos of AAP (in 1L mCRPC) prior randomization allow time for genomic testing. We evaluated impact run-in treatment on efficacy NIRA/AAP. Methods: 423 alterations randomized 1:1 or placebo (PBO)/AAP. At prespecified second interim analysis, sensitivity analysis based duration was conducted....
We sought to quantify the impact of vaping introduction on cigarette smoking across settings with varied regulatory approaches vaping.
Background: The increasing prevalence of child and adolescent overweight obesity (CAOAO) in Beijing poses significant health economic challenges. This study assesses the potential outcomes implementing specific interventions to address CAOAO Beijing. Methods: A deterministic Markov cohort model was used estimate impact five from 2025 2115: restrictions on unhealthy food marketing children, mandatory front package labeling (FOPL), family-based nutrition exercise education, school-based...
Tissue-specific immune responses are critical determinants of health-maintaining homeostasis and disease-related dysbiosis. In the context COVID-19, oral reflect local host-pathogen dynamics near site infection serve as important “windows to body,” reflecting systemic invading SARS-CoV-2 virus. This study leveraged multiplex technology characterize salivary SARS-CoV-2–specific immunological landscape (37 cytokines/chemokines 11 antibodies) during early infection. Cytokine/immune profiling...
<ns5:p><ns5:bold>Background</ns5:bold>: In India, about one million deaths occur every year due to smoking. Tobacco taxation is the most effective intervention in reducing this paper, we examine impact of a one-time large cigarette price increase, through an increase excise tax, on health and financing outcomes four Indian states.</ns5:p><ns5:p> <ns5:bold>Methods</ns5:bold>: We used extended cost-effectiveness analysis estimate, across income quintiles, life-years gained, treatment cost...
TPS5071 Background: ARN-509, a potent and selective androgen receptor (AR) antagonist, inhibits AR nuclear translocation DNA binding (Clegg, Cancer Res. 2012). AA directly biosynthesis has been approved for the treatment of mCRPC. Although ARN-509 abiraterone both target AR, each works through different mechanism: former blocks ligand binding, latter synthesis. Importantly, lack sensitivity to one AR-targeted therapy does not necessarily imply resistance another (Rathkopf, AACR 2014)....