A5039879976- Cancer-related molecular mechanisms research
- Osteoarthritis Treatment and Mechanisms
- Circular RNAs in diseases
- Renal and related cancers
- Prostate Cancer Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Ferroptosis and cancer prognosis
- Bone Metabolism and Diseases
- Renal cell carcinoma treatment
- Mesenchymal stem cell research
- Adenosine and Purinergic Signaling
- Spectroscopy and Chemometric Analyses
- Cytokine Signaling Pathways and Interactions
- Hippo pathway signaling and YAP/TAZ
- Cancer, Lipids, and Metabolism
- Shoulder Injury and Treatment
- Tendon Structure and Treatment
- Renal Diseases and Glomerulopathies
- Connective Tissue Growth Factor Research
- Inflammatory Bowel Disease
- Bone and Dental Protein Studies
- Redox biology and oxidative stress
- Urologic and reproductive health conditions
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
Jiangsu University
2025
Affiliated Hospital of Jiangsu University
2025
Xiangya Hospital Central South University
2019-2024
Central South University
2019-2023
University of British Columbia
2022
Soil and Fertilizer Institute of Hunan Province
2022
Abstract Renal fibrosis is a common pathological process that occurs with diverse etiologies in chronic kidney disease. However, its regulatory mechanisms have not yet been fully elucidated. Ferroptosis form of non-apoptotic regulated cell death driven by iron-dependent lipid peroxidation. It currently unknown whether ferroptosis initiated during unilateral ureteral obstruction (UUO)-induced renal and role has determined. In this study, we demonstrated induced tubular epithelial cells (TECs)...
Abstract Background Lumbar facet joint osteoarthritis (LFJ OA) is a common disease, and there still lack of effective disease-modifying therapies. Our aim was to determine the therapeutic effect hypoxia-treated adipose mesenchymal stem cell (ADSC)-derived exosomes (Hypo-ADSC-Exos) on protective against LFJ OA. Methods The Hypo-ADSC-Exos OA examined in lumbar spinal instability (LSI)-induced models. Spinal pain behavioural assessments CGRP (Calcitonin Gene-Related Peptide positive)...
ABSTRACT Luteolin and quercetin, which are flavonoids, present in various traditional Chinese medicines. Although they have been shown to improve obesity, the specific mechanisms of action remain unclear. This study aimed determine pivotal targets major regulatory pathways involved their using network pharmacology transcriptome sequencing. Data on luteolin/quercetin‐related were acquired from PharmMapper platform, data known obesity‐related collected OMIM GeneCards databases. Differentially...
Abstract Renal fibrosis, the ultimate common pathway of progressive nephropathy, is characterized by excess accumulation and deposition extracellular matrix (ECM) within renal interstitium glomeruli, finally resulting in end‐stage kidney failure. TGFβ1 not only abnormally increased during fibrosis but also involved ECM induction accumulation. Based on bioinformative analyses, phosphatase tensin homolog deleted chromosome ten (PTEN) focal adhesion kinase (FAK) signaling might be functions...
Treatment with metformin can lead to the recovery of pleiotropic biological activities after spinal cord injury. However, its effect on injury in aged mice remains unclear. Considering essential role angiogenesis during regeneration process, we hypothesized that activates adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway endothelial cells, thereby promoting microvascular In this study, established young and mouse models contusive using a modified...
The pathogenesis of Crohn's disease (CD) is unknown; however, angiogenesis known to play an important role in the disease. present research suggests that microRNA-21 (miR-21) may a positive regulatory disordered CD.C57 wild-type mice were divided into 6 groups. On day 0, all 2,4,6-trinitrobenzenesulfonic acid (TNBS) group given enema at concentration TNBS 100 mg/kg mouse body weight (solvent 50% alcohol). In control group, was performed with alcohol. 2, 4, and 6, agomir-21 + agomir injected...
Rotator cuff tear (RCT) is among the most common shoulder injuries and prone to rerupture after surgery. Selecting suitable subpopulations of stem cells as a new specific cell type mesenchymal has been increasingly used potential therapeutic tool in regenerative medicine. In this study, murine adipose-derived SSEA-4+CD90+PDGFRA+ subpopulation were successfully sorted, extracted, identified. These showed good proliferation differentiation potential, especially direction tendon...
Renal hypoxia and its associated oxidative stress is a common pathway for the development of kidney diseases, using dietary antioxidants such as flavan-3-ols to prevent failure has received much attention. This study investigates molecular mechanism by which hypoxia-induced cell death in renal tubular epithelial cells. Human proximal cells (HKC-8) were exposed (1% O2) presence (catechin, epicatechin, procyanidin B1, B2). Cell was examined flow cytometric analysis. Gene expression determined...
This study investigated the correlation between periprostatic fat thickness (PPFT) measured on magnetic resonance imaging and lower urinary tract symptoms, erectile function, benign prostatic hyperplasia (BPH) progression. A total of 286 treatment-naive men diagnosed with BPH in our department March 2017 February 2019 were included. Patients divided into two groups according to median value PPFT: high (PPFT >4.35 mm) PPFT group low <4.35 group. After initial evaluation, all patients...
Obstructive renal fibrosis is the consequence of abnormal extracellular matrix assembly, which eventually results in failure, acute, and end‑stage infection. MicroRNAs (miRNAs), a particular category small RNAs, modulate expression genes post-transcriptionally regulate biological activities, including fibrogenesis. The study probed to estimate key functions miR-4709-3p obstructive fibrosis. This investigation used TGF-β1 stimulated HK-2 in-vitro model, unilateral ureteral occlusion (UUO)...