A5090715715- Mesenchymal stem cell research
- Hematopoietic Stem Cell Transplantation
- MicroRNA in disease regulation
- Blood transfusion and management
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Blood groups and transfusion
- Extracellular vesicles in disease
- Immune cells in cancer
- Immune Cell Function and Interaction
- Pluripotent Stem Cells Research
- RNA Research and Splicing
- Tissue Engineering and Regenerative Medicine
- Platelet Disorders and Treatments
- Immunotherapy and Immune Responses
- Retinal Diseases and Treatments
- Lipid metabolism and disorders
- Chronic Myeloid Leukemia Treatments
- Cardiac Structural Anomalies and Repair
- Click Chemistry and Applications
- Reproductive System and Pregnancy
- PARP inhibition in cancer therapy
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
High Institute for Education and Research in Transfusion Medicine
2013-2023
Karolinska University Hospital
2021-2023
Karolinska Institutet
2020-2023
October 6 University
2022
Iran Khodro (Iran)
2013
CML is a hematopoietic stem-cell disorder emanating from breakpoint cluster region/Abelson murine leukemia 1 (BCR/ABL) translocation. Introduction of different TKIs revolutionized treatment outcome in patients, but LSCs seem insensitive to and are detectable newly diagnosed resistant patients who discontinued therapy. It has been reported that aberrantly express some CD markers such as CD26 can be used for the diagnosis targeting. In this study, we confirmed presence CD26+ patients. To...
Non-alcoholic fatty liver disease (NAFLD) is the most common which has become a public health concern. Since oxidative stress plays crucial role in pathogenesis of NAFLD, subsequent hematological disorders are expected. Therefore, antioxidant compounds such as quercetin could ameliorate related side-effect stress. The aim current study was to assess effect on parameters NAFLD patients. A randomized, double-blind, placebo-controlled trial conducted pilot study. In this 90 patients with were...
Abstract Gene modified or cytokine activated mesenchymal stem cells (MSCs) have been used as a treatment in various types of cancer. Moreover, irradiation is usually applied either standard primary adjuvant therapy. Here, we showed that the expression TNF related apoptosis-inducing ligand (TRAIL) and Dickouf-3 (Dkk-3), promising anticancer proteins, increased murine adipose-derived stromal (AD-MSCs) following activation with TNF-α, resulting induction apoptosis cancer cells. Also, effects...
Bone marrow mesenchymal stem cells (BM-MSCs) are multipotent with self-renewal properties, making them an ideal candidate for regenerative medicine. Recently, numerous studies show that about more than 99% of transplanted destroyed because the stressful microenvironment. Meanwhile, in target organs, iron overload can produce oxidative stress introducing it as most important factor. The present study was aimed at increasing BM-MSCs' viability against microenvironment using depletion by...
Macrophages are the main infiltrating immune cells in choroidal neovascularization (CNV), a hallmark of human wet, or neovascular age-related macular degeneration (AMD). Due to their plasticity and ability adapt local microenvironment tissue-dependent manner, macrophages display polar functional phenotypes characterized by cell surface markers cytokine profiles. We found accumulation hemoglobin-scavenging cluster differentiation 163 (CD163)(+) laser-induced CNV lesions higher expression...
The objective of the current study was to assess effects tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) along with their simultaneous application on proliferation pluripotency genes murine adipose tissue-derived mesenchymal stem cells (AT-MSCs). proliferation, doubling time (DT), colony-forming unit–fibroblast (CFU-F), expression, proliferation-related immunomodulatory markers MSCs were analyzed upon activation TNF-α (10 ng/ml), IFN-γ ng/ml) both (5 ng/ml + 5 ng/ml). Pluripotency...
BACKGROUND Umbilical cord blood (UCB) processing with hydroxyethyl starch (HES) is the most common protocol in banks. The quality of UCB volume reduction was guaranteed by minimum manipulation samples closed system. This study aimed to analyze and compare cell recovery viability processed using Sepax automated system presence absence HES. STUDY DESIGN AND METHODS Thirty bags a total nucleated (TNC) count more than 2.5 × 10 9 were divided two equal volume. HES solution added one bag another...
Oxidative stress and mitochondrial damage are causes of platelet storage lesions (PSLs). Mitochondrial DNA (mtDNA) to be released into the extracellular space. MtDNA in concentrates is considered damage-associated molecular patterns (DAMPs) one major PSLs. The mechanism mtDNA release has not been thoroughly investigated. This study aimed determine effect reactive oxygen species (ROS) on during storage. Ten from healthy donors were obtained this investigation. Platelet prepared by...
Although recent studies have reported different aspects of autophagy, from pro-survival to pro-death roles this process in malignant cells, the underlying mechanisms by which autophagy inhibitors contribute toward induction programmed cell death cancerous cells are still unclear. In present study, we attempted explore some molecular features pharmacological inhibition TF-1 (an acute erythroid leukemia model). Our findings indicated that ara-C induces (with alteration LC3B, p62, and Beclin-1)...
Various microRNAs (miRNAs) are expressed during development of mammalian cells, when they aid in modulating gene expression by mediating mRNA transcript cleavage and/or regulation translation rate. miR-191 and miR-451 have been shown to be critical regulators hematopoiesis important roles the induction erythroid fate decision. So, aim this study is investigation controlling mouse embryonic stem cell (mESC) differentiation toward lineage.
Recent progress in understanding the pathogenesis of premature ventricular contraction (PVC)-induced cardiomyopathy (PIC) has suggested a key role for inflammation. The aim this study was to evaluate expression messenger RNAs (mRNAs) and protein production interleukin-6 (IL-6), IL-10, tumor necrosis factor alpha (TNF-α) interferon-γ (IFN-γ) two circulating micro-RNAs related inflammation cardiovascular disease; miR-155 miR-146.The population comprised 25 patients with PIC normal left...
Platelet micro-particles (MPs) contain CXCR4 markers and are able to transfer them into hematopoietic stem cells. Therefore, effect of platelet MPs (PMPs) on the expression levels CD34 in these cells was examined. Isolated CD 133+ cultivated for 5 d span medium PMPs. Fold increase CD34+ presence 10 g/ml PMPs increased significantly. CXCR4+ cell percent compared with control (63.8 ± 6.4) (P < 0.05). were no affect clonogenicity progenitor cells.Cord blood CD133+ maintain long-term...