A5033892078- TGF-β signaling in diseases
- Proteoglycans and glycosaminoglycans research
- Protein Kinase Regulation and GTPase Signaling
- Cell Adhesion Molecules Research
- Glycosylation and Glycoproteins Research
- Receptor Mechanisms and Signaling
- Monoclonal and Polyclonal Antibodies Research
- Protease and Inhibitor Mechanisms
- Metabolism, Diabetes, and Cancer
- T-cell and B-cell Immunology
- Lipoproteins and Cardiovascular Health
- Xenotransplantation and immune response
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Peroxisome Proliferator-Activated Receptors
- Immune Cell Function and Interaction
- Nitric Oxide and Endothelin Effects
- Animal Genetics and Reproduction
- Diabetes Treatment and Management
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- PI3K/AKT/mTOR signaling in cancer
- Neuropeptides and Animal Physiology
- Signaling Pathways in Disease
- Cardiac Valve Diseases and Treatments
- Galectins and Cancer Biology
RMIT University
2012-2024
Monash University
2009-2024
Alfred Health
2012-2018
International Islamic University Malaysia
2018
Eastern Health
2012-2018
University of Macau
2018
Anhui Xinhua University
2018
Sun Yat-sen University
2018
The University of Queensland
2016-2018
Health Innovations (United States)
2013
Pharmaceutical interventions for diabetes aim to control glycaemia and prevent the development of complications, such as cardiovascular diseases. Some anti-hyperglycaemic drugs have been found adverse effects in their own right, limiting therapeutic role. Glucokinase activity pancreas is critical enhancing insulin release response hyperglycaemia. activators (GKAs) are novel agents which act by formation glucose-6-phosphate leading increased production subsequent suppression blood glucose....
Abstract Immunoglobulin family tyrosine‐based activation motifs (ITAM), which define the conserved signaling sequence EX 2 YX L/IX 7 L/I, couple T cell antigen receptor (TCR) to cellular proteins including protein tyrosine kinases (PTK) and adapter molecules. The TCR is a multichain complex with four invariant chains CD3γ, δ ϵ that each contain single ITAM ζ chain contains three ITAM. present study explores interactions of doubly phosphorylated CD3 γ, δ, determine whether they have common or...
Hyperacute rejection of pig organs by humans involves the interaction Galα(1,3)Gal with antibodies and complement. Strategies to reduce amount xenoantigen were investigated overexpression human lysosomal α-galactosidase in cultured porcine cells transgenic mice. The endothelial COS resulted a 30-fold reduction cell surface 10-fold reactivity natural antibodies. Splenocytes from mice overexpressing showed only 15–25% binding anti-Galα(1,3)Gal antibodies; however, this decrease was...
Growth factors modify the structure of glycosaminoglycan (GAG) chains on biglycan leading to enhanced LDL binding. G-protein receptor-coupled agonists such as thrombin, signal changes proteoglycans produced by vascular smooth muscle cells (VSMCs). One component classical G-protein-coupled receptor (GPCR) signaling invokes transactivation protein tyrosine kinase receptors epidermal growth factor receptor. Serine/threonine transforming factor-(TGF)-β are potent activators proteoglycan...
G protein-coupled receptor signaling is mediated by three main mechanisms of action; these are the classical pathway, β-arrestin scaffold signaling, and transactivation protein-tyrosine kinase receptors such as those for EGF PDGF. Recently, it has been demonstrated that can also mediate signals via serine/threonine receptors, most notably transforming growth factor-β family. Atherosclerosis characterized development lipid-laden plaques in blood vessel walls. Initiation plaque occurs low...
Diabetic retinopathy (DR) is the most common retinal disorder, developed in 35% of patients with diabetes mellitus. Lower serum levels 25-hydroxyvitamin D are associated increased risk developing DR. High doses active form vitamin (VD), on contrary, for a long period time may lead to hypercalcemia and an imbalance regulation bone metabolism. Herein, we studied efficacy dextran-gated carboxyphenylboronic acid (CPBA)-functionalized mesoporous silica nanoparticles (MSNs) glucose-sensitive...
Tyrosine-based activation motifs (TAMs) define a conserved signaling sequence, EX2YX2L/IX7YX2L/I, that couples the T cell antigen receptor to protein tyrosine kinases and adapter molecules. The present study shows phosphorylation of both tyrosines within motif is required for high affinity binding kinase ZAP-70 whereas single COOH-terminal optimal Shc. There were also quantitative differences in Shc association with ζ1-TAM since nM concentrations doubly phosphorylated are sufficient...
Chimeric Fc gamma R have been generated between the mouse high affinity receptor for IgG (Fc RI) and low RII) by exchanging first two domains of three-domain extracellular structure RI with homologous two-domain RII. Studies specificity binding Ig classes to these receptors defined functional regions showed some surprising results. After removal third domain RI, remaining (domains 1 2) retained capacity bind in form immune complexes, however, they bound monomeric IgG2a a reduced affinity....
The 'response to retention' hypothesis of atherogenesis proposes that proteoglycans bind and retain low-density lipoproteins (LDL) in the vessel wall. Platelet-derived growth factor (PDGF) is strongly implicated atherosclerosis stimulates proteoglycan synthesis. Here we investigated action PDGF receptor inhibitor imatinib on PDGF-mediated biosynthesis vitro, lipid deposition aortic wall vivo carotid artery ex vivo. In human vSMCs, inhibited mediated (35)S-SO(4) incorporation into by 31% (P <...
Atherosclerosis is the underlying pathological process of most cardiovascular disease. A critical component "response to retention" hypothesis atherogenesis proteoglycan/low density lipoprotein (LDL) binding. Transforming growth factor β (TGF-β) present in atherosclerotic lesions, regulates vascular smooth muscle cell (VSMC) proteoglycan synthesis via an unknown signaling pathway, and increases proteoglycan/LDL This pathway was investigated using activin receptor-like kinase 5 (ALK5)...