A5034782327- HER2/EGFR in Cancer Research
- Cytokine Signaling Pathways and Interactions
- Neuroinflammation and Neurodegeneration Mechanisms
- Enzyme Catalysis and Immobilization
- Hormonal Regulation and Hypertension
- Immune cells in cancer
- Axon Guidance and Neuronal Signaling
- Neurogenesis and neuroplasticity mechanisms
- Hereditary Neurological Disorders
- Vagus Nerve Stimulation Research
- Ovarian cancer diagnosis and treatment
- Nerve injury and regeneration
- Cancer, Lipids, and Metabolism
- Spine and Intervertebral Disc Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Extracellular vesicles in disease
- Microbial Natural Products and Biosynthesis
- Monoclonal and Polyclonal Antibodies Research
- Chemical Synthesis and Analysis
University of Michigan–Ann Arbor
2022-2024
University of Oklahoma
2020-2021
Upon trauma, the adult murine peripheral nervous system (PNS) displays a remarkable degree of spontaneous anatomical and functional regeneration. To explore extrinsic mechanisms neural repair, we carried out single-cell analysis naïve mouse sciatic nerve, blood mononuclear cells, crushed nerves at 1 day, 3 days, 7 days following injury. During first week, monocytes macrophages (Mo/Mac) rapidly accumulate in injured nerve undergo extensive metabolic reprogramming. Proinflammatory Mo/Mac with...
In adult mammals, injured retinal ganglion cells (RGCs) fail to spontaneously regrow severed axons, resulting in permanent visual deficits. Robust axon growth, however, is observed after intra-ocular injection of particulate β-glucan isolated from yeast. Blood-borne myeloid rapidly respond β-glucan, releasing numerous pro-regenerative factors. Unfortunately, the effects are undermined by damage inflicted an overactive immune system. Here, we demonstrate that protection inflamed vasculature...
The development of precision drugs for the selective treatment ovarian cancer will require targeting proliferative factors selectively expressed in tumors or unique physiological microenvironments specific tumors. Here, we report that oxysterol-binding protein (OSBP)-related 4 (ORP4) is a potential druggable target cells. ORP4 has limited expression normal tissues and was recently recognized to be cancer-specific driver cellular proliferation, including patient-isolated leukemias. We...
Tryprostatin A and B are prenylated, tryptophan-containing, diketopiperazine natural products, displaying cytotoxic activity through different mechanisms of action. The presence the 6-methoxy substituent on indole moiety tryprostatin was shown to be essential for dual inhibition topoisomerase II tubulin polymerization. However, inability perform late-stage modification ring has limited structure–activity relationship studies this class products. Herein, we describe an efficient...
Abstract Upon trauma, the adult murine PNS displays a remarkable degree of spontaneous anatomical and functional regeneration. To explore extrinsic mechanisms neural repair, we carried out single cell analysis naïve mouse sciatic nerve, peripheral blood mononuclear cells, crushed nerves at 1-day, 3-days, 7-days following injury. During first week, monocytes macrophages (Mo/Mac) rapidly accumulate in injured nerve undergo extensive metabolic reprogramming. Proinflammatory Mo/Mac show high...
Abstract Like all receptor tyrosine kinases (RTKs), ErbB4 signals through a canonical signaling involving phosphorylation cascades. However, can also signal non-canonical mechanism whereby the intracellular domain is released into cytoplasm by regulated intermembrane proteolysis (RIP) and translocates to nucleus where it regulates transcription. These different mechanisms depend on generation of alternative spliced isoforms, RIP cleavable ErbB4-JMa an uncleavable ErbB4-JMb. Non-canonical has...
Abstract Like all receptor tyrosine kinases (RTKs), ErbB4 signals through a canonical signaling involving phosphorylation cascades. However, can also signal non-canonical mechanism whereby the intracellular domain is released into cytoplasm by regulated intramembrane proteolysis (RIP) and translocates to nucleus where it regulates transcription. These different mechanisms depend on generation of alternative spliced isoforms, RIP cleavable ErbB4-JMa an uncleavable ErbB4-JMb. Non-canonical has...