A5020450818- Selenium in Biological Systems
- Medical and Biological Ozone Research
- Lung Cancer Diagnosis and Treatment
- Paraoxonase enzyme and polymorphisms
- Vitamin D Research Studies
- Colorectal Cancer Screening and Detection
- Cancer Research and Treatments
- Lung Cancer Treatments and Mutations
- Inflammatory Bowel Disease
- Global Health Care Issues
- Fluoride Effects and Removal
- Head and Neck Cancer Studies
- Genetic factors in colorectal cancer
- Alkaline Phosphatase Research Studies
- Moringa oleifera research and applications
- Radiomics and Machine Learning in Medical Imaging
- Hormonal Regulation and Hypertension
- Global Cancer Incidence and Screening
- Colorectal and Anal Carcinomas
- Glutathione Transferases and Polymorphisms
- Bladder and Urothelial Cancer Treatments
Cleveland Clinic
2025
Southern Illinois University School of Medicine
2021-2023
Vanderbilt University Medical Center
2021
Abstract Lynch's syndrome is a common cause of hereditary colorectal cancer (CRC), resulting in higher risk CRC and development subsequent, metachronous (mCRC). Beyond treating the primary cancer, surgeons patients must decide on whether performing an extended colectomy, to reduce mCRC, worth change function that comes with larger operation. Considerations include likelihood for morbidity quality life after resection, impact pathogenic variant, certain other reduction options. The...
<h3>PURPOSE</h3> We assessed low-dose computed tomography (LDCT) screening for lung cancer using a proactive patient education/recruitment program. <h3>METHODS</h3> identified patients aged 55-80 years from family medicine group. In the retrospective phase (March-August, 2019), were categorized as current/former/never smokers, and eligibility was determined. Patients who underwent LDCT in past year, along with outcomes, documented. prospective (2020), same cohort did not undergo proactively...
Abstract Patients with inflammatory bowel disease demonstrate selenium nutritional deficiencies and are at increased risk for colon cancer. Previously, we determined that global loss of the selenium-containing antioxidant protein, Selenoprotein P (SELENOP), exacerbates experimental colitis-associated cancer (CAC). Using a variety tissue-specific knockout mouse lines, further epithelial-derived SELENOP served as primary mediator severity, Villin-Cre; Selenop f/f (Selenop ΔIEC) mice have tumor...
Abstract Many selenium-containing “selenoproteins” function as antioxidants, and work by our lab others has demonstrated that selenoproteins often protect against intestinal inflammatory diseases, including colitis. Glutathione peroxidase 1 (GPx1) is a ubiquitous, mitochondrial cytosolic selenoprotein which catalyzes the reduction of hydrogen peroxide glutathione. Previously, we determined despite its antioxidant role, loss GPx1 greatly reduced disease severity in dextran sodium sulfate...
Abstract Selenium (Se) is an essential trace element incorporated into selenoproteins (SEPs), which provide a broad scope of antioxidant functions. Se status inversely correlates with inflammatory bowel disease (IBD) severity, and animal models have shown that deficiency worsens colitis colitis-associated cancer (CAC). One the most highly expressed functionally critical SEPs Selenoprotein P (SEPP1/SELENOP). SELENOP serves two known roles: 1) distributing throughout organism, 2) acting as...