A5068421447- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Pluripotent Stem Cells Research
- Immune responses and vaccinations
- Cancer-related molecular mechanisms research
- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Prenatal Screening and Diagnostics
- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- Neonatal Respiratory Health Research
- Machine Learning in Healthcare
University of California, San Francisco
2021-2024
Stanford University
2023-2024
Human-induced pluripotent stem cells (hiPSCs) have emerged as a promising in vitro model system for studying neurodevelopment. However, current models remain limited their ability to incorporate tunable biomechanical signaling cues imparted by the extracellular matrix (ECM). The native brain ECM is viscoelastic and stress-relaxing, exhibiting time-dependent response an applied force. To recapitulate remodelability of neural ECM, we developed family protein-engineered hydrogels that exhibit...
Introduction Maternal intervillous monocytes (MIMs) and fetal Hofbauer cells (HBCs) are myeloid-derived immune at the maternal-fetal interface. reproductive history is associated with differential risk of pregnancy complications. The molecular phenotypes roles these distinct monocyte/macrophage populations influence gravidity on has not been systematically investigated. Methods Here, we used RNA sequencing to study transcriptional profiles MIMs HBCs in normal term pregnancies. Results Our...
Abstract Maternal intervillous monocytes (MIMs) and fetal Hofbauer cells (HBCs) are myeloid-derived immune at the maternal-fetal interface. Little is known regarding molecular phenotypes roles of these distinct monocyte/macrophage populations. Here, we used RNA sequencing to investigate transcriptional profiles MIMs HBCs in six normal term pregnancies. Our analyses revealed transcriptomes HBCs. Genes involved differentiation cell organization pathways were more highly expressed vs. In...