A5045185604- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- RNA modifications and cancer
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- DNA Repair Mechanisms
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Economic and Financial Impacts of Cancer
- HER2/EGFR in Cancer Research
- Lymphoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Multiple and Secondary Primary Cancers
- Digestive system and related health
- Gastric Cancer Management and Outcomes
- Cancer Research and Treatments
- Adrenal and Paraganglionic Tumors
- Hepatocellular Carcinoma Treatment and Prognosis
- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Cancer, Lipids, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
University of Glasgow
2025
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2023
University of South Alabama
2017-2021
USA Mitchell Cancer Institute
2017-2021
Northwestern University
2016-2020
Ochsner Medical Center
2016
Northwestern Medicine
2016
Palmetto Hematology Oncology
2016
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
2016
Ochsner Health System
2015
Genomic analysis of tumor tissue is the standard technique for identifying DNA alterations in malignancies. circulating cell-free (cfDNA) represents a relatively non-invasive method assessing genomic using peripheral blood. We compared concordance between cfDNA and biopsies this retrospective study. Twenty-eight patients with advanced solid tumors paired next-generation sequencing were identified. Sixty-five genes common to both assays. Concordance was defined as presence or absence...
Abstract KRAS is the most commonly mutated oncogene in NSCLC and development of direct inhibitors has renewed interest this molecular variant. Different mutations may represent a unique biologic context with different prognostic therapeutic impact. We sought to characterize genomic landscapes advanced, KRAS-mutated non–small cell lung cancer (NSCLC) large national cohort help guide future development. Molecular profiles 17,095 specimens were obtained using DNA next-generation sequencing 592...
The genetic mechanisms associated with progression of high-risk non-muscle-invasive bladder cancer (HR-NMIBC) have not been described. We conducted selective next-generation sequencing (NGS) HR-NMIBC and compared the genomic profiles cancers that responded to intravesical therapy those progressed muscle-invasive or advanced disease. DNA was extracted from paraffin-embedded sections 25 HR-NMIBCs (22 T1HG; 3 TaHG without carcinoma in situ). Ten patients developed (pT2+ N+) ("progressors")....
The Cancer Genome Atlas (TCGA) showed that 16% of colorectal cancers (CRCs) display DNA repair mechanisms and high tumor mutational burden (TMB). Although, there is accumulating evidence greater benefit immunotherapy in tumors with high-TMB, its impact on response to chemotherapy unknown.In this retrospective cohort study, we investigated the TMB progression-free survival (PFS) CRC patients treated at tertiary care oncology clinics who had their profiled by next-generation sequencing (NGS)....
Background/Objectives: Dietary manipulation with carbohydrate restriction has been extensively investigated in diabetes prevention programmes. Carbohydrate (CHO) quality, rather than quantity, is associated various metabolic outcomes. Few studies examined the fibre/CHO ratio on lipid profiles, liver fat and insulin resistance individuals impaired glucose tolerance (IGT). Methods: In this comprehensive cross-sectional study, we evaluated association of carbohydrate-related nutritional factors...
Angiotensin receptor blockers (ARBs) are commonly used antihypertensive medication with several other additional proven benefits. Recent controversy on association of lung cancer and solid malignancy the use ARBs is concerning, although follow-up studies have shown no such association.We data from Department Veterans Affairs electronic medical record system registries to conduct a retrospective cohort study that compared first-time ARB users nonusers in 1:15 ratio, after balancing for many...
Exosomes are important mediators of intercellular communications and play pivotal roles in cancer progression, metastasis chemoresistance. CD63 CD9 widely accepted exosomal markers. In patients with pancreatic ductal adenocarcinoma (PDAC), positive correlation between expression overall survival (OS) was reported. conserved all no reported prognostic significance. This study explored the significance using immunohistochemistry (IHC) PDAC mixed racial background.Between 2012 2016, 49 had...
HER2 alteration (mutation and/or amplification) is associated with poor survival in NSCLC and can mediate resistance to EGFR tyrosine kinase inhibitors.We retrospectively analyzed de-identified molecular information from 12,946 samples that underwent next-generation sequencing (NGS) Caris Life Sciences. The objectives were determine the prevalence type of alterations without as a co-mutation. Insurance claims utilized obtain outcomes data.Three hundred twenty-one patients (2.5%) had...
We are developing the fluoropyrimidine polymer F10 to overcome limitations of 5-fluorouracil (5-FU) that result from inefficient metabolism 5-fluoro-2'-deoxyuridine-5'-mono- and tri-phosphate, deoxyribonucleotide metabolites responsible for 5-FU's anticancer activity. is much more cytotoxic than 5-FU colorectal cancer (CRC) cells; however, mechanism enhanced cytotoxicity remains incompletely characterized. Using DNA fiber analysis, we establish decreases replication fork velocity causes...
EGFR and cMET cross-talk is involved in breast cancer (BC) progression resistance to different targeted therapies, however little known about the co-expression patterns of or its prognostic significance BC. Protein levels EGFR, their phosphorylated proteins were measured 825 BC samples using reverse phase protein array (RPPA). Given unimodal distribution proteins, median was selected as a cut-off after sensitivity analyses. Kaplan-Meier survival curves used estimate relapse-free (RFS)...
Not for resuscitation in India still remains an abstract concept with no clear guidelines or legal frame work. Cardiopulmonary is a complex medical intervention which often used inappropriately hospitalized patients and usually guided by decision making rather than patient-directed choices. Patient autonomy weak relatives are expected to make this big short time at of great emotional distress. This article outlines concepts around ethics medico aspects not resuscitation, especially Indian setting.
9056 Background: Malignant pleural mesothelioma (MPM) is a relatively uncommon malignancy with poor prognosis and no major therapeutic breakthroughs over the past decade. Better understanding of genomic landscape distribution immune biomarkers in this disease has potential to enable development novel therapies. Methods: We analyzed molecular profiles 222 MPM tumors using next-generation sequencing 592 genes utilizing Caris Life Sciences platform. Genes were grouped into pathways: DNA damage...
In two Korean and Italian studies, the adherence rate (AR) to ASSLD 2005 guidelines in management of hepatocellular carcinoma (HCC) was 60%. a US study, AR American Association for Study Liver Disease (AASLD) 73.3%, 26.8%, 25.3%, 58.8% patients with Barcelona Clinic Cancer (BCLC) Stage A, B, C, D, respectively, nonadherence associated longer overall survival (OS) BCLC D. Here, we explored AASLD 2018 its impact on OS.Between 2017 2019, 148 unique treatment-naïve HCC were identified. Patients...