A5073365629- Cancer therapeutics and mechanisms
- DNA Repair Mechanisms
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Protein Interaction Studies and Fluorescence Analysis
- Oxidative Organic Chemistry Reactions
- Advanced Biosensing Techniques and Applications
- Drug Transport and Resistance Mechanisms
- PARP inhibition in cancer therapy
- Synthesis and Biological Evaluation
- Chemical Synthesis and Reactions
- Antibiotics Pharmacokinetics and Efficacy
- Monoclonal and Polyclonal Antibodies Research
- Crystallography and molecular interactions
- RNA and protein synthesis mechanisms
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Chemical Reactions and Mechanisms
- Carcinogens and Genotoxicity Assessment
- CRISPR and Genetic Engineering
- Synthetic Organic Chemistry Methods
- Porphyrin and Phthalocyanine Chemistry
- Protein Structure and Dynamics
Unité en Sciences Biologiques et Biotechnologies de Nantes
2015-2024
Centre National de la Recherche Scientifique
2015-2024
Nantes Université
2015-2024
Bioénergétique et Ingénierie des Protéines
2014-2023
N.D. Zelinsky Institute of Organic Chemistry
2014-2016
Biocat
2013
3M (United States)
2011
Laboratoire Physiologie Biotechnologie des Algues
2009
Institut de Biologie et de Chimie des Protéines
2002
Université de Reims Champagne-Ardenne
1995-2000
Abstract Aim To compare the effect of glimepiride in combination with metformin monotherapy each drug on glycaemic control Type 2 diabetic patients. Design and methods Randomized, double‐blind, double‐dummy, parallel‐group multicentre study conducted France. patients aged 35–70 years inadequately controlled by 2550 mg daily for at least 4 weeks were randomized to either metformin, or glimepiride. Results Three hundred seventy‐two 56 ± 8 treated 5 months. Combination treatment was...
The catalyst H3+x PMo12-x+6 Mox+5 O40 supported on SiO2 was developed for peroxidation of 1,3- and 1,5-diketones with hydrogen peroxide the formation bridged 1,2,4,5-tetraoxanes 1,2,4-trioxolanes (ozonides) high yield based isolated products (up to 86 90 %, respectively) under heterogeneous conditions. Synthesis peroxides conditions is a rare process represents challenge this field chemistry, because tend decompose surface . A new class antifungal agents crop protection, that is, cyclic...
This article discloses a new horizon for the application of peroxides in medical chemistry. Stable cyclic are demonstrated to have cytotoxic activity against cancer cells; addition mechanism action is proposed. Synthetic bridged 1,2,4,5-tetraoxanes and ozonides were effective HepG2 cells some selectively targeted liver (the selectivity indexes compounds 11 b 12 8 5, respectively). In cases, tetraoxanes more selective than paclitaxel, artemisinin, artesunic acid. Annexin V flow-cytometry...
DNA topoisomerase (top) I inhibition activity of the natural alkaloid fagaronine (NSC157995) and its new synthetic derivative ethoxidine (12-ethoxy-benzo[c]phenanthridine) has been correlated with their molecular interactions sequence specificity within complexes. Flow linear dichroism shows that exhibits same relaxation as at 10-fold lower concentration. The patterns cleavage by top show enhancement CPT-dependent sites 0.016–50 μm concentrations fagaronine, whereas suppress both I-specific...
Circular dichroism (CD) and Raman spectroscopy were employed in order to locate a camptothecin (CPT)‐binding site within human serum albumin (HSA) identify protein structural transformations induced by CPT binding. A competitive binding of 3′‐azido‐3′‐deoxythymidine (a ligand occupying IIIA sub‐domain the protein) HSA does not show any competition demonstrates that ligands are located different sites, whereas HSA‐bound may be replaced warfarin, IIA protein. CD spectra HSA/CPT complexes...
Human Rad51 is a key element of recombinational DNA repair and related to the resistance cancer cells chemo‐ radiotherapies. The protein thus potential target anti‐cancer treatment. crystallographic analysis shows that BRC‐motif BRCA2 tumor suppressor in contact with subunit–subunit interface could prevent filament formation Rad51. However, biochemical indicates peptide 69 amino acids preferentially binds N‐terminal part We show experimentally short 28 derived from BRC4 motif dissociates its...
Abstract The reaction of β,δ‐triketones with an ethereal solution H 2 O catalyzed by heteropoly acids in the presence a polar aprotic co‐solvent proceeds via three pathways to form classes peroxides: tricyclic monoperoxides, bridged tetraoxanes, and pair stereoisomeric ozonides. is unusual that produces tetraoxanes ozonides one carbonyl groups remaining intact. In synthesis peroxide ring formed hydrogen two at β positions. from ketones unique process which ozonide participation δ...
Nanoparticles of biocompatible and biodegradable polymers such as poly(lactic-co-glycolic acid) (PLGA) are widely used drug delivery systems for the administration biomolecules like proteins.The purpose this work is to validate a novel formulation method by phase separation phenomenon using non-toxic solvent glycofurol (GF) in order encapsulate proteins into PLGA nanoparticles.Nanoprecipitates model protein (lysozyme) therapeutic (TGF-β1) were formed ensure their stability upon subsequent...
MINT‐7034009: cABL (uniprotkb:P00519) physically interacts (MI:0218) with RAD51 (uniprotkb:Q06609) by pull down (MI:0096)
Cyclic organosilicon triperoxides were found to be vinyl-selective free-radical initiators for thermal curing at 100–180 °C of vinyl-terminated polydimethylsiloxane and trimethylsilyl-terminated polymethylhydrosiloxane producing homogeneous transparent silicone rubbers with antibacterial properties.
Peptide ligand-induced dimerization of the extracellular region epidermal growth factor receptor (sEGFR) is central to signal transduction many cellular processes. A small molecule microarray screen has been developed search for non-peptide compounds able bind sEGFR. We describe discovery nitro-benzoxadiazole (NBD) that enhance tyrosine phosphorylation EGFR and thereby trigger downstream signaling pathways other kinases in cancer cells. The protein profile cells exposed NBD some extent...
Activation of cell signaling by reactive chemicals and pollutants is an important issue for human health. It has been shown that lipophilic nitro-benzoxadiazole (NBD) compounds rapidly move across the plasma membrane enhance Epidermal Growth Factor Receptor (EGFR) tyrosine phosphorylation in cancer cells. Unlike ligand-dependent activation, mechanism this induction relies on generation hydrogen peroxide, which involved activation catalytic site receptor inactivation protein phosphatase...