Microbial biocontrol agents are efficient and environment-friendly in eradicating plant pathogenic bacteria. In recent years, Bacillus velezensis has gained popularity as a potential agent many countries. Several B. velezensis-based products, previously identified amyloliquefaciens or subsp. plantarum, have received commercial approval, particularly China Europe. this study, we compiled research findings on related to the production of antimicrobials, volatile organic compounds, induction...

TAZ physically interacts with RUNX2 by pull down (View interaction)

Phorbol 12-myristate 13-acetate (PMA) is a potent tumor promoter and highly inflammatory in nature. Here, we investigated the toxic effects of PMA on different model system. (10 μg) caused chromosomal aberrations Allium cepa root tip induced mitotic dysfunction. Similarly, embryonic larval deformities plummeted survivability rate zebrafish embryo dose-dependent manner. Persistently, treatment immortalized human keratinocyte (HaCaT) cells massive rush at 4 h drop cell 24 h. Concomitantly,...

Rice (<i>Oryza sativa</i>), a staple crop worldwide, is severely threatened by bacterial panicle blight caused <i>Burkholderia glumae</i>, leading to substantial yield losses. The lack of effective chemical treatments and resistant rice cultivars highlights the urgent need for alternative solutions. In this study, 1,134 plant extracts were screened antibacterial activity against <i>B. glumae</i> using agar disc diffusion liquid broth assays. Thirty-three...

Three new sesterterpenoids, phorbaketals A (1), B (2), and C (3) which have a spiroketal of the hydrobenzopyran moiety, were isolated from Korean marine sponge Phorbas sp. Their complete structures elucidated by spectral chemical methods. They exhibited moderate cytotoxicity against human colorectal, hepatoma, lung cancer cell lines. Furthermore, cultivation bacterial fraction afforded compound 1.

Abstract In this study, we isolated a total of 238 culturable putative bacterial endophytes from four Pinus species ( densiflora , P . koraiensis rigida and thunbergii ) across 18 sampling sites in Korea. The samples were cultured de Man Rogosa Sharpe humic acid-vitamin agar media. These selective media used to isolate lactic acid bacteria Actinobacteria respectively. Analysis using 16S ribosomal DNA sequencing grouped the into 107 operational taxonomic units (OTUs) belonging 48 genera....

Melanoma is known to aggressively metastasize and one of the prominent causes skin cancer mortality. This study was designed assess molecular mechanism decursinol angelate (DA) against murine melanoma cell line (B16F10 cells). Treatment DA resulted in growth inhibition cycle arrest at G0/G1 (

Staphylococcus aureus biofilm formation is a pivotal mechanism in the development of drug resistance, conferring resilience against conventional antibiotics. This study investigates inhibitory effects Actinostemma lobatum (A. lobatum) Maxim extracts on S. and their antihemolytic activities, with particular focus identifying active antibiofilm antihemolysis compound, quercetin. Seven solvent twelve sub-fractions were evaluated four strains. The ethyl acetate fraction (10 to 100 μg/mL)...

This study evaluated the effects of Rorippa cantoniensis (Lour.) ohwi extract (RCE) on factors associated with inflammation-related skin lesions in RAW 264.7 and HaCaT cells. RCE inhibited levels proinflammatory mediators cytokines such as nitric oxide (NO), prostaglandin E2 (PGE2), interleukin (IL)-6, tumor necrosis factor (TNF)-α lipopolysaccharide (LPS)-stimulated In addition, significantly expression chemokines MDC/CCL22, TARC/CCL17, RANTES/CCL5, CTSS, IL-6, IL-1β, TNF-α cells...

Two new sesterterpenoids, phorbasones A (1) and B (2), were isolated from the Korean marine sponge Phorbas sp. Their complete structures elucidated by spectral data chemical reactions. Phorbasone exhibited a positive effect on calcium deposition activity in C3H10T1/2 cells. The biogenic origin of core structure is believed to be through novel rearrangement ansellone carbon structure.

The white-spotted flower chafer (

Densanins A (1) and B (2) were isolated from the sponge Haliclona densaspicula. On basis of spectral data Mosher ester method, complete structures characterized as hexacyclic diamine alkaloids, which probably derived 3-alkylpyridine. Compounds 1 2 showed relatively potent inhibitory effects on lipopolysaccharide-induced nitric oxide production in BV2 microglial cells with IC50 values 1.05 2.14 μM, respectively.

Following isolation of the polyhydroxy compound, ostreol B, from cultivated cells toxic dinoflagellate Ostreopsis cf. ovata collected in South Korea, 1D and 2D NMR spectroscopy were employed to determine planar chemical structure this which contained a tetrahydropyran ring, two terminal double bonds, 21 hydroxyl groups. The absolute configurations all stereogenic carbon centers B then determined through combination J-based configuration analysis, rotating frame Overhauser effect...

The previously unknown compounds 1–4, acetylenic acids with one or two iodine atom(s), were isolated from the marine sponges Suberites mammilaris and japonicus. Their complete structures determined using NMR mass spectrometry. methylated 1a 2a exhibited a strong NO inhibitory effect on RAW264.7 cells, while 3a 4a inactive in but highly active BV2 microglia cells.

Acuminolide A (1), along with pectenotoxin II (PTX-2), dinophysistoxin I (DTX-1), okadaic acid (OA), and 7-epi-PTX-2 seco acid, was isolated from a large-scale cultivation of the dinoflagellate Dinophysis acuminata. The new 33-membered macrolide 1 characterized by detailed analysis 2D NMR MS data. Its relative stereochemistry elucidated on basis ROESY correlations J-based analysis. In contrast to other well-known toxins that were isolated, showed no cytotoxicity against four cancer cell...

Plants produce chemicals of immense diversity that provide great opportunities for development new antifungal compounds. In search environment-friendly alternatives to the fungicide current use, we screened plant extracts obtained from more than eight hundred materials collected in Korea their activity against model pathogenic fungus, Magnaporthe oryzae. This initial screening identified activities eleven extract samples, among which nine showed reproducibility follow-up screening. These...

Oenothera biennis (evening primrose) produces bioactive substances with a diverse range of pharmacological functions. However, it is currently unknown whether extract prepared from the aerial parts O. (APOB) can protect skin against oxidative stress.The aim this study to investigate protective effects APOB stress-induced damage in human keratinocytes (HaCaT) and elucidate underlying mechanisms.We pretreated HaCaT cells various concentrations or antioxidant N-acetyl-L-cysteine before applying...

Biofilm formation by Staphylococcus aureus plays a critical role in the persistence of chronic infections due to its tolerance against antimicrobial agents. Here, we investigated antibiofilm efficacy six phorbaketals: phorbaketal A (1), acetate (2), B (3), (4), C (5), and (6), isolated from Korean marine sponge Phorbas sp. Of these compounds, 3 5 were found be effective inhibitors biofilm two S. strains, which included methicillin-resistant aureus. In addition, also inhibited production...

Free-living amoebae (FLA) rarely cause human infections but can invoke fatal in the central nervous system (CNS). No consensus treatment has been established for FLA of CNS, emphasizing urgent need to discover or develop safe and effective drugs. Flavonoids, natural compounds from plants plant-derived products, are known have antiprotozoan activities against several pathogenic protozoa parasites. The anti-FLA activity flavonoids also proposed, while their antiamoebic needs be emperically...