A5016071881- Pancreatic function and diabetes
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Veterinary Medicine and Surgery
- Diabetes Management and Research
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Ion Transport and Channel Regulation
- Liver Disease and Transplantation
- Pancreatitis Pathology and Treatment
- Cardiovascular Conditions and Treatments
- Adipose Tissue and Metabolism
- Electrolyte and hormonal disorders
- Diet, Metabolism, and Disease
- Regulation of Appetite and Obesity
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Thyroid Disorders and Treatments
- Tissue Engineering and Regenerative Medicine
- Growth Hormone and Insulin-like Growth Factors
- Veterinary Oncology Research
- Diet and metabolism studies
- Parathyroid Disorders and Treatments
- Magnesium in Health and Disease
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
Kansas State University
2013-2025
University of Michigan
2014-2020
A. Alfred Taubman Health Care Center
2020
Ontario Veterinary College
2017
Mayo Clinic
2004-2009
Dartmouth Hospital
2004
Dartmouth College
2004
Veterinary Medical Teaching Hospital
2004
New York State College of Veterinary Medicine
1997-2002
Cornell University
1994-2002
Case records of 36 dogs with confirmed leptospirosis diagnosed at the New York State College Veterinary Medicine from 1980 to 1995 were reviewed retrospectively, and clinical, serological pathological findings recorded characterise epidemiology this disease in upstate York. Titres directed predominantly against serovars grippotyphosa and/or pomona 31 34 dogs. Convalescent titres measured for 53 per cent The most common clinical presentation was acute renal failure. Increased liver enzyme...
Insulin secretion has been studied in isolated rat pancreatic islets under stringent Ca(2+)-depleted, Ca(2+)-free conditions. Under these conditions, the effect of 16.7 mM glucose to stimulate insulin release was abolished. Forskolin, which activates adenylyl cyclase, also failed presence either low or high concentrations. A phorbol ester (phorbol 12-myristate 13-acetate; PMA) increased rate slightly and this further by glucose. Remarkably, both forskolin PMA, strongly augmented release. The...
The role of the calcium-binding protein, calbindin-D<sub>28k</sub> in potassium/depolarization-stimulated increases cytosolic free Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<sub>i</sub>) and insulin release was investigated pancreatic islets from nullmutant mice (knockouts; KO) or wild type β cell lines stably transfected overexpressing calbindin. Using single KO stimulation with 45 mm KCl, peak [Ca<sup>2+</sup>]<sub>i</sub> 3.5-fold greater compared (<i>p</i> < 0.01) remained higher...
Cyclic AMP potentiates glucose-stimulated insulin release by actions predominantly at a site, or sites, distal to the elevation of cytosolic free Ca2+ concentration ([Ca2+]i). Glucose also acts [Ca2+]i via ATP-sensitive K+ channel (K+ATP channel)-independent signaling pathway. Accordingly, using rat pancreatic islets, we studied location action cAMP and its interaction with glucose Forskolin, an activator adenylyl cyclase, raised intracellular levels enhanced KCl-induced (Ca2+ -stimulated)...
Objectives The objective of this study was to compare plasma glucagon-like peptide-2 (GLP-2) concentrations in cats with chronic enteropathies (CE) those healthy cats. Methods Nineteen client-owned a histopathologic diagnosis either idiopathic enteropathy (CIE) or low-grade lymphoma and six were enrolled prospective between 2 December 2021 9 June 2023. Fasted postprandial GLP-2 measured via ELISA CE at the time gastrointestinal biopsies obtained before treatment. In CIE, re-evaluated after 1...
Hepatoportal microvascular dysplasia (MVD), a congenital disorder of the hepatic vasculature, is described in kindred Cairn Terrier dogs. dogs (n = 165) were evaluated using serum bile acid test. Affected dogs, identified by abnormal fasting or postprandial concentrations, divided into 2 groups. Group 1 147) used for pedigree analysis. 18) characterized on basis history, physical examination, clinicopathologic studies, diagnostic imaging liver and portal circulation, histopathology....
Pulmonary thromboembolism (PTE) is rarely diagnosed in cats, and the clinical features of disease are not well known. PTE was at postmortem examination 17 a prevalence 0.06% over 24‐year period. The age affected cats ranged from 10 months to 18 years, although young (<4 years) old (10 were more commonly than middleaged cats. Males females equally affected. majority with (n = 16) had concurrent disease, which often severe. most common diseases identified association neoplasia, anemia...
Total serum magnesium concentration ([Mg 2+ ] s ) was prospectively determined for 57 cats admitted to the intensive care unit (ICU) of Cornell University Hospital Animals. Data were collected and analyzed determine following: prevalence incidence [Mg abnormalities, medical disorders associated with altered , association other electrolyte length hospitalization abnormalities versus those normal survival abnormal . The point 26%, period 46%, cumulative 23%. Hypermagnesemia potassium ( P =...
Abstract OBJECTIVE To investigate safety and effectiveness of velagliflozin oral solution as sole therapy in naïve previously insulin-treated diabetic cats. ANIMALS 252 client-owned cats receiving ≥ 2 doses velagliflozin; 214 (85%) diabetics 38 (15%) diabetics. PROCEDURES Prospective, baseline-controlled, open-label clinical field trial. Cats received orally, once daily. Physical examinations blood collections were performed days 0, 3, 7, 30, 60, 120, 180. RESULTS Data are median (range)....
Pulmonary thromboembolism (PTE) is rarely diagnosed in cats, and the clinical features of disease are not well known.PTE was at postmortem examination 17 a prevalence 0.06% over 24-year period.The age affected cats ranged from 10 months to 18 years, although young (Ͻ4 years) old (Ͼ10 were more commonly than middleaged cats.Males females equally affected.The majority with PTE (n ϭ 16) had concurrent disease, which often severe.The most common diseases identified association neoplasia, anemia...
Dysautonomia of domestic animals is pathologically characterized by chromatolytic degeneration the neurons in autonomic nervous ganglia that results clinical signs related to dysfunction or failure sympathetic and parasympathetic systems. The exact cause unknown. It has a poor prognosis among all species reported no definitive treatment available currently. To date, most feline cases have occurred United Kingdom Scandinavia. here highlight signs, physical examination findings, system...
To describe the patient population, disease severity, and outcome in dogs with immune-mediated hemolytic anemia (IMHA) that underwent splenectomy. compare presurgical postsurgical data.Retrospective case series.Emergency clinic/referral hospital.Ten diagnosed IMHA.Splenectomy addition to standard medical management for IMHA.Medical records of 10 IMHA, which a splenectomy was performed were reviewed. The population analyzed regards physical clinicopathologic data, treatment, outcome. Outcome...
The purpose of this study was to evaluate the ability specific types multiple-choice questions delivered using an Audience Response System (ARS) maintain student attention in a professional educational setting. Veterinary students (N=324) enrolled first three years curriculum were presented with four different ARS question (knowledge base, discussion, polling, and psychological investment) no (control) during five lectures by 10 instructors core courses. Toward end lecture, polled determine...
Abstract Objectives – To (1) determine a reference interval for cardiac troponin I (cTnI) using point‐of‐care device in normal dogs and compare the results with those published by manufacturer (2) if cTnI differs among cardiogenic noncardiogenic respiratory distress. Design Prospective observational study. Setting Emergency referral veterinary hospital. Animals Twenty‐six clinically 67 Interventions All underwent whole blood sampling concentrations. Measurements Results Normal had median...
Abstract Objective: To examine the relative contributions of sodium and glucose to serum effective osmolality presence abnormalities in diabetic dogs cats. Design: Retrospective study. Setting: A university‐based referral hospital. Animals: Diabetic ( n =14) cats =13) consecutively admitted hospital over a 6‐month period. Interventions: None Measurements: Serum biochemistry assessments. Main results: The mean concentration was higher than Total (Osm T ), E concentrations sodium, potassium,...
To determine the relationship between prognosis of seriously injured patients requiring emergency surgery and intraoperative end-tidal CO2 variables "excess Pco2."Retrospective chart review 100 admitted to Detroit Receiving Hospital major (mortality rate 40%). Standard monitoring, including continuous capnography, plus arterial blood analyses every 15 30 minutes during surgery.After resuscitation for 45 90 minutes, 11 had a systolic pressure < mm Hg and, these patients, 10 (91%) died. Of...