A5045291404- Veterinary Oncology Research
- Microbial infections and disease research
- Viral Infections and Immunology Research
- Human-Animal Interaction Studies
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Music Therapy and Health
- Mosquito-borne diseases and control
- Turtle Biology and Conservation
- Infant Health and Development
- Viral gastroenteritis research and epidemiology
- Mycobacterium research and diagnosis
- Gastrointestinal Tumor Research and Treatment
- Rabies epidemiology and control
- Tuberculosis Research and Epidemiology
- Pancreatic and Hepatic Oncology Research
- Respiratory viral infections research
Oklahoma State University
2024-2025
Kansas State University
2019-2025
Louisiana State University
2019-2022
Baton Rouge Clinic
2022
Louisiana Department of Wildlife and Fisheries
2019
The ever-evolving SARS-CoV-2 variants necessitate the development of additional oral antivirals. This study presents systematic design quinoline-containing papain-like protease (PLpro) inhibitors as potential antiviral drug candidates. By leveraging recently discovered Val70Ub binding site in PLpro, we designed a series quinoline analogs demonstrating potent PLpro inhibition and activity. Notably, X-ray crystal structures 6 lead compounds reveal that 2-aryl substitution can occupy either...
Our objective was to determine if feline-specific music played in a veterinary clinical setting would promote lower cat stress scores (CSSs), mean handling scale (HSs) and reduced neutrophil:lymphocyte ratios (NLRs) cats during physical examinations.
Objectives The objective of this study was to compare plasma glucagon-like peptide-2 (GLP-2) concentrations in cats with chronic enteropathies (CE) those healthy cats. Methods Nineteen client-owned a histopathologic diagnosis either idiopathic enteropathy (CIE) or low-grade lymphoma and six were enrolled prospective between 2 December 2021 9 June 2023. Fasted postprandial GLP-2 measured via ELISA CE at the time gastrointestinal biopsies obtained before treatment. In CIE, re-evaluated after 1...
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced impaired antiviral immunity and excessive inflammatory responses cause lethal pneumonia. However, the in vivo roles of key pattern recognition receptors that elicit protective fatal responses, specifically lungs, are not well described. Coronaviruses possess single-stranded RNA genome activates TLR7/8 to induce an interferon (IFN) robust cytokine response. Here, using wild-type TLR7-deficient (TLR7 −/− ) mice...
We document a case of Mycobacterium kansasii, rare, zoonotic bacterium, in white-tailed deer (WTD; Odocoileus virginianus) East Baton Rouge Parish, Louisiana. Grossly, the had fibrinous pleuropneumonia with yellow, mineralized nodules scattered throughout lungs and extending to pleura. The kidneys were enlarged numerous pale foci cortex. Microscopically, pulmonary architecture was replaced by variably sized, multifocal-to-coalescing granulomas peripheral histiocytes fewer multinucleate giant...
Two central bearded dragons (Pogona vitticeps), a 3-y-old male and 5-y-old female, were diagnosed with different manifestations of lymphoma at the Kansas State Veterinary Diagnostic Laboratory between 2019 2020. The was presented for postmortem evaluation in poor body condition. Microscopically, nearly all examined organs contained variable numbers neoplastic round cells. Neoplastic cells stomach liver had moderate immunoreactivity to CD3 consistent multicentric T-cell lymphoma,...
In collaboration with the American College of Veterinary Pathologists.