A5081645133- Genomics and Chromatin Dynamics
- Chromosomal and Genetic Variations
- RNA Research and Splicing
- Genomic variations and chromosomal abnormalities
- Nuclear Structure and Function
- Retinal Development and Disorders
- Animal Genetics and Reproduction
- RNA and protein synthesis mechanisms
- Advanced Fluorescence Microscopy Techniques
- DNA Repair Mechanisms
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Molecular Biology Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Gene expression and cancer classification
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Neurobiology and Insect Physiology Research
- CRISPR and Genetic Engineering
- Physiological and biochemical adaptations
- Genetic Mapping and Diversity in Plants and Animals
- Planarian Biology and Electrostimulation
- Genetic Syndromes and Imprinting
- Telomeres, Telomerase, and Senescence
- Thyroid Disorders and Treatments
- Pluripotent Stem Cells Research
Ludwig-Maximilians-Universität München
2016-2025
Urologische Klinik München
2020
Center for Integrated Protein Science Munich
2011-2018
LMU Klinikum
2005-2017
Elucid Bioimaging
2006
National Institute of Health Sciences
2002
Heidelberg University
2002
Institut de Génétique Humaine
2002
Institut für Urheber- und Medienrecht
2000
St Petersburg University
1992-1997
Studies of higher-order chromatin arrangements are an essential part ongoing attempts to explore changes in epigenome structure and their functional implications during development cell differentiation. However, the extent cell-type-specificity three-dimensional (3D) chromosome has remained controversial. In order overcome technical limitations previous studies, we have developed tools that allow quantitative 3D positional mapping all chromosomes simultaneously. We present unequivocal...
The nuclear lamins function in the regulation of replication, transcription, and epigenetic modifications chromatin. However, mechanisms responsible for these lamin functions are poorly understood. We demonstrate that A- B-type form separate, but interacting, stable meshworks lamina have different mobilities nucleoplasm as determined by fluorescence correlation spectroscopy (FCS). Silencing B1 (LB1) expression dramatically increases meshwork size mobility nucleoplasmic A (LA). changes mesh...
We demonstrate that the nuclear topological arrangement of chromosome territories (CTs) has been conserved during primate evolution over a period about 30 million years. Recent evidence shows positioning chromatin in human lymphocyte nuclei is correlated with gene density. For example, 19 territories, which contain mainly gene-dense and early replicating chromatin, are located toward center, whereas 18 consist gene-poor later close to border. In this study, we subjected seven different...
We report for the first time genomics of a nuclear compartment eukaryotic cell. 454 sequencing and microarray analysis revealed pattern nucleolus-associated chromatin domains (NADs) in linear human genome identified different gene families certain satellite repeats as major building blocks NADs, which constitute about 4% genome. Bioinformatic evaluation showed that NAD-localized genes take part specific biological processes, like response to other organisms, odor perception, tissue...
Mutations in the LaminA gene are a common cause of monogenic dilated cardiomyopathy. Here we show that mice with cardiomyocyte-specific Lmna deletion develop cardiac failure and die within 3-4 weeks after inducing mutation. When same mutations induced genetically deficient LINC complex protein SUN1, life is extended to more than one year. Disruption SUN1's function also accomplished by transducing expressing dominant-negative SUN1 miniprotein cardiomyocytes, using cardiotrophic Adeno...