A5091685143- Immune Cell Function and Interaction
- Salivary Gland Disorders and Functions
- SARS-CoV-2 and COVID-19 Research
- T-cell and B-cell Immunology
- Salivary Gland Tumors Diagnosis and Treatment
- Inflammasome and immune disorders
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- Animal Virus Infections Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Legionella and Acanthamoeba research
- Kawasaki Disease and Coronary Complications
- Immune responses and vaccinations
- Zoonotic diseases and public health
- Inflammatory Bowel Disease
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Lymphoma Diagnosis and Treatment
- Diabetes and associated disorders
- Digestive system and related health
- Autoimmune and Inflammatory Disorders Research
- Eosinophilic Esophagitis
- COVID-19 Clinical Research Studies
- Cancer Immunotherapy and Biomarkers
- vaccines and immunoinformatics approaches
University of Palermo
2021-2024
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo
2022-2023
Aim of this study was to investigate the expression interleukin (IL)-40, a new cytokine associated with B cells homoeostasis and immune response, in primary Sjögren syndrome (pSS) pSS-associated lymphomas.29 patients pSS 24 controls were enrolled. Minor salivary gland (MSG) biopsies from patients, parotid lymphoma obtained. Quantitative gene analysis by TaqMan real-time PCR immunohistochemistry for IL-40 performed on MSG. MSG cellular sources determined flow-cytometry immunofluorescence....
Primary Sjogren syndrome (pSS) is the second most common autoimmune disorder worldwide, which, in worst scenario, progresses to Non-Hodgkin Lymphoma (NHL). Despite extensive studies, there still a lack of knowledge about developing pSS for NHL. This study focused on cells' signaling progression NHL type diffuse large B-cell lymphoma (DLBCL). Using bulk RNA and single cell analysis, we found five novel pathologic-independent clusters DLBCL based signaling. receptor (BCR) was identified as...
Glial tumors alone account for 40% of all CNS and present a low survival rate. The tumor microenvironment is critical regulator progression therapeutic effectiveness in glioma. Growing evidence from numerous studies human solid tumor-infiltrating CD8+ T cells indicates that tissue-resident memory (TRM) represent substantial subpopulation lymphocytes (TILs). Although it reported some types cancer patients with high immune infiltration tend to have better outcomes than infiltration, seems this...
Anaplasma phagocytophilum are obligatory intracellular bacteria that preferentially replicate inside leukocytes by utilizing biological compounds and processes of these primary host defensive cells. In this study, bioinformatics analysis was conducted to further characterize A. phagocytophilum-host interactions using the neutrophil-like model human Caucasian promyelocytic leukemia HL60 We detected a hierarchy molecules involved in phagocytophilum-HL60 with overrepresentation infected cells...
Background: The pathogenesis of pSS relies on a complex interplay between both innate and adaptive immune responses in which B cells play pivotal role. Their chronic aberrant hyperactivation may drive clonal escape consequent lymphomagenesis [1]. In the last few years, have emerged as potential effector cells, able to release wide range cytokines that actively contribute shape microenvironment they act in. Recently, IL-40, novel cell associated cytokine encoded by an uncharacterized gene...
We retrospective analyzed in silico the binding affinity of SARS-CoV-2 peptides to MHC class I HLA-A, -B, and –C molecules different countries with high low morbidity mortality rates. used bioinformatics approach screen 18260 epitopes that have significant for alleles found approximately five thousand predicted nonamers bind alleles. Those show frequently occurring regarding HLA frequencies within populations can vary due differences their evolutionary histories, we showed those correlation...
We retrospective analyzed in silico the binding affinity of SARS-CoV-2 peptides to MHC class I HLA-A, -B, and –C molecules different countries with high low morbidity mortality rates. used bioinformatics approach screen 18260 epitopes that have significant for alleles found approximately five thousand predicted nonamers bind alleles. Those show a occurring regarding HLA frequencies within populations can vary due differences their evolutionary histories, we showed those correlations pandemic...