Bisphenol A (BPA) is a widespread compound associated with the manufacture of many consumer products. The BPA-induced reproductive toxicity was reported to be mainly attributed oxidative stress. However, role antioxidants usage decrease injurious effects BPA, on male functions, remains unveil. present research established evaluate selenium (Se) and its nano form (NSe) as protective agents alleviate testicular toxicity. Ninety mature albino rats were assigned into six equal groups: negative...

This study aims to investigate the effect of Premna odorata (P. odorata) (Lamiaceae) on hepatic and nephrotoxicity induced by aluminum chloride (AlCl3) in rat. Wistar male rats were equally classified into four groups: control, P. extract (500 mg/kg B.W.), AlCl3 (70 plus groups. All treatments given orally for 4 weeks. Serum transaminases some biochemical parameters, renal antioxidant/oxidant biomarker; tumor necrosis factor-α (TNF-α); matrix metalloproteinase (MMP9) transforming growth...

Salvia plants become more popular due to their health-promoting and antioxidant potential. The present study aimed investigate the safety limit of officinalis terpenoids-rich fraction in Wistar rats. Thirty adult female rats were divided equally into three groups. first one was control. second third groups received as a single oral dose 2 3 g/kg b.w., respectively. During experimental period, any abnormal clinical signs, morbidity mortality rates, well weekly body weight gain recorded. At...

The objective of this study was to investigate the influence deltamethrin (DLM)on brain function and find whether DLM-induced neurotoxicity is prevented by treatment with cinnamon oil. Four groups ten Wistar albino male rats each were used. Group I (control) received saline only. II oil alone at 0.5 mg/kg B.W. intraperitonally, whereas III orally DLM 6 Groups IV treated plus for 21 days induce neurotoxicity. Rat behaviour, acetylcholine esterase (AChE), serotonin, oxidative stress profile...

Methotrexate (MTX) has been widely used for treatment of cancer and rheumatoid arthritis, but its use limited by nephrotoxicity. This study was carried out to determine whether garlic exerts a protective effect against MTX-induced nephrotoxicity.Nephrotoxicity induced in rats after single i.p. injection MTX (20 mg/kg). Garlic extract (1 mL/100 g b.w.) given orally 7 days before administration. Serum samples were collected evaluate urea, creatinine, sodium, phosphorous, potassium, calcium....

Cadmium (Cd) is a highly toxic heavy metal that adversely affects both human and animal health. Chronic cadmium exposure causes serious kidney damage. The current study investigated the protective role of cerium oxide nanoparticles (CeO2NPs) against chloride (CdCl2)-induced renal injury.One hundred twenty male albino rats were divided into 6 equal groups. Group (C): considered as control group which was given distilled water orally. (NC.1 NC.5): injected i.p. with nanoceria at dose (0.1 0.5...

Objective: The current study was conducted to investigate the protective effect of selenium preparations against reproductive toxicity bisphenol A. Materials and Methods: Sixty adult Albino male rats (aged from 2-3 months average weight 150-180 g) were used they randomly divided into sex equal groups.Group I served as control, group II orally administered BPA in a dose level 1/10 LD 50 (150 mg kgG 1 b.wt.) for 8 successive weeks, III gavaged with plus ionized (3 b.wt.), IV animals this given...

Rheumatoid arthritis (RA) is the most common chronic systemic, immune-mediated inflammatory disorderthat attacks flexible joints and also may affect many tissues organs. The present study was designed to assess effect of atorvastatin vitamin D on RA compare it with that methotrexate in female Wistar albino rats. induced by subcutaneousinjection Complete Freund’s Adjuvant (CFA). Seventy rats were divided into (7) groups, each 10 Group I kept as control. II injected 0.4 ml CFA for 12 days....

Rats were fed on diets containing rapeseed oil, either low or high erucic acid content as well the hydrogenated ones for 6 weeks. Body weight gain, biochemical and pathological parameters investigated. The data showed body gain rats rape oil (LERo) compared with those (HERo), partially diets. All non significant changes total lipids, cholesterol, GPT GOT, except diet which decrease cholesterol. Alkaline phosphatase however a decrease, while plasma phospholipids increase in diet....

Most of the currently used toxicity assays for environmental chemicals use acute or chronic systemic reproductive endpoints rather than neurobehavioral endpoints. In addition, current standard approaches to assess are time-consuming. Therefore, with increasing numbers being developed potentially harmful effects in higher vertebrates, including humans, more efficient means assessing neuro- and required. Here we discuss a Galliformes-based avian test battery which developmental is assessed by...

Aim: The aim of the present study was to understand molecular relationship between nematode (parasite) and fish (host) through codon usage bias (CUB) analysis. Methodology: Codon analysis has been performed in Carassius gibelio (Prussian carp) parasite Anisakis simplex. complete coding sequences (CDS) C. A. simplex (Nematode) were retrieved from National Center for Biotechnology Information followed that we have bioinformatics pattern host parasite. Results: Different CUB indices like...

Deltamethrin (DLM) is a synthetic pyrethroid type-II known to cause many adverse effects in experimental animals such as endocrine disruption, reproductive toxicity, and negative impact on gametogenesis.The present study was conducted evaluate the protective role of wheat germ oil against toxicity induced by male albino rats through evaluation semen picture, measuring testosterone levels, DNA fragmentation percentage pathologic changes testes.Thirty were divided into three groups (10 each);...

D ue to the widespread and intensive use of deltame- thrin (DM) in agriculture public health, it has become one most environmental industrial pollutants that are toxic humans, animals, fishes birds.The common sources human animal exposure deltamethrin polluted water food (Kumar et al., 2015).The liver kidney reported among tissues affected due DM since is main site metabolism principal organ its elimination (Abdel-Daim 2013).Deltamethrin oxidized by cytochrome P450 enzymes elevates reactive...

In this study the effect of garlic and coriander extract in comparison to albendazole against experimental infection Haemonchus contortus (H.Contortus) sheep was evaluated.Sheep were divided into 5 groups; 1 st one represented control negative.The remaining groups infected orally with 1750 H. infective larvae (L3) equally subdivided positive (infected untreated), treated (5ml/animal), (0.9g/ kg b.w.) Albendazole (10 mg/ b.w).The treatments done on 4 th 6 week post infection.Fecal samples...

Cadmium is one of the most harmful environmental pollutants that causes various risks to animal and human health (Zhu et al., 2019).It a highly toxic metal present commonly in living world (Moulis Thévenod 2010; Liu al. 2019).Cadmium naturally available soil, water as well air due wide utilization industries such plastics, fuels, pigments, batteries, plating fertilizers (Genchi 2020; Umar 2021).

The current study was performed to evaluate the effect of acute and chronic hepatotoxicity induced by paracetamol thioacetamide respectively on serum hormonal levels biochemical parameters.Female Wistar albino rats were divided into 3 equal groups (C), (P) (T).Group (C) kept as control, group received orally (500 mg/kg b.wt) daily for 15 days those (T) injected (200 intraperitonialy twice/ week 90 days.In P group, results revealed significant elevation in liver enzyme activities (ALT, AST...