A5112213518- Geotechnical Engineering and Underground Structures
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Structural Integrity and Reliability Analysis
- Earthquake and Disaster Impact Studies
- Multi-Criteria Decision Making
- Cancer Immunotherapy and Biomarkers
- Neutropenia and Cancer Infections
- Chronic Lymphocytic Leukemia Research
- Chemotherapy-related skin toxicity
- Anesthesia and Pain Management
- Multiple and Secondary Primary Cancers
- Colorectal and Anal Carcinomas
- Construction Project Management and Performance
- Advanced Breast Cancer Therapies
- Energy, Environment, Agriculture Analysis
- Innovative concrete reinforcement materials
- Neurotransmitter Receptor Influence on Behavior
- Geotechnical Engineering and Soil Stabilization
- Urban and spatial planning
- Anesthesia and Sedative Agents
- Inflammatory Biomarkers in Disease Prognosis
- Multiple Myeloma Research and Treatments
- Chemotherapy-induced organ toxicity mitigation
- Chronic Myeloid Leukemia Treatments
National Hospital Organization Hokkaido Medical Center
2010-2024
Sapporo National Hospital
2010-2024
Hokkaido University Hospital
2024
The University of Tokyo
2019
Kobe University
1987-2015
University of Tehran
2013
Iwate Prefectural University
2008
Tohoku University
2006
Hokkaido Pharmaceutical University
2004
Columbia University
1979
The current state of the art seismic risk analysis for underground lifeline systems, particularly water transmission network system, is reviewed. An emphasis in review placed on major causes system damages and procedures design decision unique to systems. A methodology then developed an example performed a simplified version City Los Angeles indicating each step assumption used therein. has been carried through point where sample physically damaged systems are simulated by means Monte Carlo...
Neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios can indicate poor disease prognosis are inflammation markers. We investigated the role of NLR PLR as effective predictive markers immune-related adverse event (irAE) onset in patients treated with nivolumab.We retrospectively analysed 73 gastric renal cancer nivolumab at Hokkaido Cancer Centre from January 2017 to June 2020. were calculated initiation treatment irAE onset. identified risk factors for Grade 3-4 using NLR,...
This paper presents a three-dimensional quasi-static analysis of continuous or jointed pipelines. Transfer Matrix Method was applied to the providing for nonlinear behaviors joints and soil frictions. An improved computer program ERAUL-II (Earthquake Response Analysis Underground Lifelines-II) developed numerical computations. First, response analyses were carried out pipe systems with steel cast iron materials subject large ground deformations seismic motions. Analytical results show that...
Medications that target programmed cell death protein-1 (PD-1) have proven effective. However, blockade of PD-1/Programmed death-ligand 1(PD-L1) causes immune-related adverse events (irAEs). Characteristics this irAE include many symptom, low in frequency, and difficulty prevention. The key to a successful ICI-related treatment lies the management irAEs resulting from immune checkpoint inhibitor (ICI) treatment. Although it is difficult predict irAE, we tried extract features expression...
The side effects of sunitinib, namely onset hypertension and hypothyroidism, have been reported to be predictive biomarkers treatment efficacy. However, the relationship between hypothyroidism prolongation survival in with axitinib, a drug similar has not yet reported.In this study, we examined caused by axitinib overall (OS) progression-free (PFS).In retrospective 44 Japanese patients, including 30 men 14 women, were enrolled. average age subjects study was 67 years.During treatment, 68%...
Background: Association between baseline medications plus neutrophil-to-lymphocyte ratio (NLR) and the effectiveness of immune checkpoint inhibitor (ICI) platinum doublet remains unknown, despite several reported prognostic models. We used real-world data to investigate whether NLR predict survival outcomes in patients with advanced non-small-cell lung cancer (NSCLC) receiving ICI doublet. Methods: This multicenter, retrospective, observational study conducted Japan December 2018 March 2021...
The association between abemaciclib dose reduction and treatment adherence is not clear. In this study, we examined real-world data of Japanese patients with advanced breast cancer (ABC) to determine how related continuation.This retrospective observational study involved 120 consecutive ABC who received from December 2018 March 2021. time failure (TTF) was estimated using the Kaplan-Meier method. Univariate multivariate analyses were performed identify factors associated a TTF >365 days...
Alectinib is recommended for anaplastic lymphoma kinase fusion gene-positive non-small cell lung cancer. We have experienced early alectinib discontinuation due to disease progression and adverse effects in real world. Because has a high protein-binding rate of >99%, low serum albumin may increase the concentration free drug affect efficacy events. However, no association between clinical impact been reported. The purpose this study was determine effect on time-to-treatment failure (TTF)...
In this research, behavior of The Greater Tehran gas distribution pipelines is evaluated in case seismic wave propagation. By synchronizing and adjustment maps the pipelines, ground conditions inputs, various different cases for evaluation are selected then analyzed by finite elements method. numerical evaluations, pipe specifications (including material, size, end bends), soil along with attributes peak acceleration, time history directivity) considered. After conducting results, basic...
Background: Cetuximab-induced skin disorder is common in colorectal cancer (CRC), and known to affect prolonged overall survival (OS). Patients with left-sided CRC survive longer than those right-sided CRC, among treated combination cetuximab chemotherapy. However, no study has evaluated patient prognosis terms of OS progression-free (PFS) relation both tumor location disorder. This aimed determine the incidence according analyze relationship OS. Methods: metastatic (mCRC) standard...
<title>Abstract</title> <bold>Purpose</bold> Dexamethasone is an antiemetic drug widely used to prevent nausea and vomiting caused by anticancer drugs. However, dexamethasone can cause several side effects even after short-term administration. Therefore, the development of dexamethasone-free therapies has been recognized as important challenge. The objective this study was investigate efficacy safety palonosetron, aprepitant, olanzapine. <bold>Methods</bold> Patients who were...
Dexamethasone is an antiemetic drug widely used to prevent nausea and vomiting caused by anticancer drugs. However, dexamethasone can cause several side effects even after short-term administration. Therefore, the development of dexamethasone-free therapies has been recognized as important challenge. The objective this study was investigate efficacy safety palonosetron, aprepitant, olanzapine. Patients who were chemotherapy-naïve scheduled receive highly emetogenic chemotherapy for breast...
The management of capecitabine-related hand-foot syndrome (HFS) is critical to avoid progression the through early detection and response; HFS involves joint medication by physicians pharmacists (hospital community pharmacists). This study aimed evaluate effectiveness collaborative in cancer patients with comparing its traditional response using monitoring reports from pharmacists.
Apalutamide induces severe skin adverse events (sAEs) in 14.7% of Japanese patients, leading to treatment discontinuation. To maximize the management sAEs patients taking apalutamide for prostate cancer, we conducted pharmacist outpatient clinics receiving setting. During these sessions, were informed about care management, including application moisturizers prevent sAEs. This study aimed evaluate usefulness pharmacist-led services managing
This paper investigates the effects of lifeline malfunction on loss human lives during 1995 Kobe earthquakes.Firstly those were reviewed for firefighting and hospital waters relating to water supply lifelines.Those which might have been saved if lifelines had worked shortly after earthquake are analyzed based records operation counted as approximately 32 45 people.Next, an exclusive system introduced into fire fragile areas earthquakes is designed giving basic procedures costeffectiveness.
Head-up displays (HUDs), which present information on windshields of vehicles, have attracted attention as a method for presenting varied to drivers while they are driving. The advantage HUD is that the amount eye movement involved when confirming presented smaller in comparison with conventional in-vehicle devices, thereby enabling driver concentrate driving taking cognizance information. However, large cognitive load could distract driver. Therefore, quantitative evaluation necessary...
The degrees of adverse effects with carboplatin (CBDCA) are influenced by interindividual differences in the area under curve (AUC), whereas renal function is not considered CBDCA dose design for dexamethasone, etoposide, ifosfamide, and (DeVIC) therapy. We conducted this study to evaluate association between AUC incidence severe thrombocytopenia patients treated DeVIC or without rituximab (DeVIC ± R).We retrospectively analyzed clinical data 36 non-Hodgkin's lymphoma who received R May 2013...
Therapy for patients of metastatic breast cancer based on palbociclib, a cyclin-dependent kinase 4/6 inhibitor, has been approved in Japan. However, the risk factors palbociclib-induced severe neutropenia Japanese are rarely reported. Hence, present study is aimed to identify adverse events requiring palbociclib dose reduction or discontinuation, and necessary more stable strategy treatment continuation. This retrospective cohort analysis included with advanced treated 125 mg/d palbociclib....
Abstract Treatment using docetaxel (DOC) and ramucirumab (RAM) is an effective regimen in second or later line advanced non-small cell lung carcinoma (NSCLC) treatment. However, it induces severe adverse effects, resulting treatment reduction such as dose and/or discontinuation. This study aimed to reveal the factor(s) associated with DOC + RAM. We retrospectively evaluated patients NSCLC (n = 155). of course due effects was conducted 25.8% participants, relative intensity at 95.7 ± 8.4% for...