A5027621627- Hepatitis C virus research
- Galectins and Cancer Biology
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Protein Tyrosine Phosphatases
- Epigenetics and DNA Methylation
- HIV Research and Treatment
- RNA Research and Splicing
- Nuclear Structure and Function
- Hepatitis B Virus Studies
- Cancer-related gene regulation
Uppsala University
2021-2023
Nuclear mRNA metabolism is regulated by multiple proteins, which either directly bind to RNA or form multiprotein complexes. The RNA-binding protein ZC3H11A involved in nuclear export, NF-κB signaling, and essential during mouse embryo development. Furthermore, previous studies have shown that important for nuclear-replicating viruses. However, detailed biochemical characterization of the has been lacking. In this study, we established interactome human cells. We demonstrate poly(A)-binding...
Hepatitis C virus (HCV) is the major causative pathogen associated with liver cirrhosis and hepatocellular carcinoma. The main virion component, core (C) protein, has been implicated in several aspects of HCV pathology including oncogenesis immune subversion. Here we show that expression protein induced specific tyrosine phosphorylation TCR-related signaling proteins ZAP-70, LAT PLC-γ T cells. Stable specifically reduced Src homology domain 2-containing phosphatase 1 (SHP-1) mRNA...
Hepatitis C virus (HCV) is the primary pathogen responsible for liver cirrhosis and hepatocellular carcinoma. The main virion component, core (C) protein, has been linked to several aspects of HCV pathology, including oncogenesis, immune evasion stress responses. We others have previously shown that expression in various cell lines activates Ca2+ signaling alters homeostasis. In this study, we identified two distinct protein regions are required activation Ca2+/NFAT signaling. basic...
Hepatitis C virus (HCV) is the major causative pathogen associated with hepatocellular carcinoma and liver cirrhosis. The main virion component, Core (C) protein, involved in multiple aspects of HCV pathology including oncogenesis immune evasion. In this study, we established a next-generation bisulfite sequencing (NGS-BS) protocol to analyze CpG methylation profile at tumor suppressor gene SHP-1 P2 promoter as model system. Our data show that protein expression immortalized T cells...