A5000941837- RNA modifications and cancer
- Hepatitis C virus research
- RNA Research and Splicing
- Viral Infections and Vectors
- Immune Cell Function and Interaction
- Nuclear Structure and Function
- Hepatitis B Virus Studies
- Influenza Virus Research Studies
- HIV Research and Treatment
- Respiratory viral infections research
- vaccines and immunoinformatics approaches
- Genetics and Neurodevelopmental Disorders
- NF-κB Signaling Pathways
- Cytokine Signaling Pathways and Interactions
- Research on Leishmaniasis Studies
- Animal Virus Infections Studies
- HIV-related health complications and treatments
- Cytomegalovirus and herpesvirus research
- Eosinophilic Disorders and Syndromes
- RNA regulation and disease
- Immune Response and Inflammation
- Adrenal Hormones and Disorders
- Trypanosoma species research and implications
- interferon and immune responses
- Liver Disease Diagnosis and Treatment
Karolinska Institutet
2024-2025
Uppsala University
2020-2023
Tehran University of Medical Sciences
2018-2021
Ahvaz Jundishapur University of Medical Sciences
2013
The persistence of HIV-1 latency reservoirs in CD4+ T cells is a significant obstacle for curing HIV-1. Shock-and-kill strategies, which aim to reactivate latent followed by cytotoxic clearance, have shown limited success vivo due insufficient efficacy reversal agents (LRAs) and off-target effects. Natural killer (NK) cells, with their ability mediate cytotoxicity independent antigen specificity, offer promising avenue enhancing the shock-and-kill approach. Previously, we observed that...
Nuclear mRNA metabolism is regulated by multiple proteins, which either directly bind to RNA or form multiprotein complexes. The RNA-binding protein ZC3H11A involved in nuclear export, NF-κB signaling, and essential during mouse embryo development. Furthermore, previous studies have shown that important for nuclear-replicating viruses. However, detailed biochemical characterization of the has been lacking. In this study, we established interactome human cells. We demonstrate poly(A)-binding...
ZC3H11A is a cellular protein associated with the transcription export (TREX) complex that induced during heat-shock. Several nuclear-replicating viruses exploit mRNA mechanism of for their efficient replication. Here we show plays role in regulation NF-κB signal transduction. Depletion resulted enhanced mediated signaling, upregulation numerous innate immune related mRNAs, including IL-6 and large group interferon-stimulated genes. absence correlated an increased factor binding to promoter...
Human adenoviruses (HAdVs) are common pathogens causing various self-limiting diseases, such as the cold and conjunctivitis. Even though have been studied for more than 6 decades, there still gaps in understanding how virus interferes with host cell to achieve efficient growth.
Feeble cellular responses induced by T cell-based vaccines are a major challenge for the development of an effective vaccine against Hepatitis C virus (HCV) infection. To address this challenge, potential N-terminal fragment gp96 heat shock protein (rNT (gp96) as adjuvant was evaluated and compared to that CpG (as recognized Th1-type adjuvant) in formulation HCV core/NS3 antigens three immunization strategies protein/protein, DNA/DNA, DNA/protein. Immunized mice were elicited immune week 3...
Background: Influenza A and B viruses are the major causative agents of human respiratory infections, these responsible for considerable mortality morbidity around world. Objectives: The objective this study was to determine frequency influenza among suspected patients with influenza-like syndrome by RT- PCR assay in Khuzestan province Iran during 2009-2010. Patients Methods: Nasopharyngeal swabs were collected from 655 March 2009 February 2010. Clinical samples taken within 48 hours initial...
<title>Abstract</title> The persistence of HIV-1 latency reservoirs in CD4<sup>+</sup> T cells is a significant obstacle for curing HIV-1. Shock-and-kill strategies, which aim to reactivate latent followed by cytotoxic clearance, have shown limited success <italic>in vivo</italic> due insufficient efficacy reversal agents (LRAs) and off-target effects. Natural killer (NK) cells, with their ability mediate cytotoxicity independent antigen specificity, offer promising avenue enhancing the...
Abstract Nuclear mRNA metabolism is regulated by multiple proteins, which either directly bind to RNA or form multi-protein complexes. The RNA-binding protein ZC3H11A involved in nuclear export, and NF-κB signaling essential during mouse embryo development. Furthermore, previous studies have shown that important for nuclear-replicating viruses. However, detailed biochemical characterization of the has been lacking. In this study, we established interactome human cells. We demonstrate...
The interleukin 28B (IL28B) genotype is associated with changes of lipid metabolism in patients infected hepatitis C virus (HCV). association steatosis serum levels adiponectin chronic (CHC) has also been documented. This study aimed for the evaluation IL28B and as well SNPs different clinicopathological parameters HCV-infected patients.All 142 received peg-interferon plus ribavirin. Detection rs8099917 rs12979860 IL-28B genotypes was done specific primers. Serum IL28 were measured using...
Background: Development of an effective prophylactic vaccine is the optimal long-term goal for eventual control HCV infection. An should be able to elicit neutralizing antibodies (NAbs). Glycoprotein E2 major target NAbs. Methods: In this study, we designed and constructed a DNA (pcDNA-E2-NT(gp96)) encoding fusion protein composed ectodomain (genotype 1a) N-terminal domain gp96 as biological adjuvant. Two possible forms protein, namely E2-NT(gp96) NT(gp96)-E2, were made subjected in silico...
Hepatitis B virus is one of the transfusion transmissible infections. Despite availability hepatitis (HBV) vaccine and screening tests but still danger transmission via blood high in some regions. The objective this study was to determine trend seroprevalence over an 11-year period (2005-2015).In study, 355,083 donors were estimated for surface antigen (HBs Ag) seropositivity during 2005-2015 who referred infusion centers Lorestan province. Third-generation ELISA method used detect HBs...