A5006305183- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Animal Disease Management and Epidemiology
- Electrochemical sensors and biosensors
- Vector-Borne Animal Diseases
- interferon and immune responses
- T-cell and Retrovirus Studies
- Immune Response and Inflammation
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- RNA Research and Splicing
- Advanced Nanomaterials in Catalysis
- RNA regulation and disease
- Influenza Virus Research Studies
- RNA Interference and Gene Delivery
- Analytical Chemistry and Sensors
- Viral Infections and Immunology Research
- Electrochemical Analysis and Applications
- Molecular Sensors and Ion Detection
- Animal health and immunology
- Genetics and Neurodevelopmental Disorders
- Biosensors and Analytical Detection
- Nanocluster Synthesis and Applications
- Musculoskeletal Disorders and Rehabilitation
- Immune Cell Function and Interaction
Uppsala University
2019-2024
Al-Azhar University
2019-2024
University of Nizwa
2024
University of Dayton
2023
South Dakota State University
2012-2020
South Valley University
2015
Pathogenic bacteria cause disease outbreaks and threaten human health, prompting the research on advanced detection assays. Herein, we developed a selective molecular imprinted aptasensor for sensitive prompt quantitation of Staphylococcus aureus (S. aureus) bacteria. The was constructed by immobilization aptamer gold nanoparticles modified magnetic (apt-AuNPs@ Fe3O4). A functional monomer (o-phenylenediamine, o-phen) electro-polymerized surface as-synthesized nanocomposite in presence...
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Nuclear mRNA metabolism is regulated by multiple proteins, which either directly bind to RNA or form multiprotein complexes. The RNA-binding protein ZC3H11A involved in nuclear export, NF-κB signaling, and essential during mouse embryo development. Furthermore, previous studies have shown that important for nuclear-replicating viruses. However, detailed biochemical characterization of the has been lacking. In this study, we established interactome human cells. We demonstrate poly(A)-binding...
Dendritic cells (DC) are important antigen presentation that monitor, process, and present to T cells. Viruses infect DC can have a devastating impact on the immune system. In this study, ability of bovine viral diarrhea virus (BVDV) replicate produce infectious in monocyte-derived dendritic (Mo-DC) monocytes was studied. The study also examined effect BVDV infection Mo-DC expression cell surface markers, including MHCI, MHCII, CD86, which critical for function response. Peripheral blood...
Virus infected immune cells can rapidly respond to the invader by activating inflammasome and as a consequence release proinflammatory cytokines eventually die pyroptosis. In human adenovirus-5 (Ad5) THP-1 cells, inhibition of NLRP3 activation was demonstrated decreased secretion HMGB1 matured forms caspase-1and IL-1ß. An Ad5 mutant virus defective in expression non-coding VA RNAI failed inhibit addition displayed formation ASC specks increased cell lysis. This required phylogenetically...
ZC3H11A is a cellular protein associated with the transcription export (TREX) complex that induced during heat-shock. Several nuclear-replicating viruses exploit mRNA mechanism of for their efficient replication. Here we show plays role in regulation NF-κB signal transduction. Depletion resulted enhanced mediated signaling, upregulation numerous innate immune related mRNAs, including IL-6 and large group interferon-stimulated genes. absence correlated an increased factor binding to promoter...
Human adenoviruses (HAdVs) are common pathogens causing various self-limiting diseases, such as the cold and conjunctivitis. Even though have been studied for more than 6 decades, there still gaps in understanding how virus interferes with host cell to achieve efficient growth.
In this research paper, a novel "signal on-off" ratiometric-based electrochemical platform was developed for the sensitive and selective detection of captopril. Ratiometric responses were achieved by fabricating molecularly imprinted polymers (MIPs) on surface graphite electrode (GE) decorated with nitrogen (N) sulfur (S) co-doped porous carbon silver nanoparticles (Ag). The MIP layer formed
CCCH-type zinc figure proteins (ZFP) are small cellular that structurally maintained by ions. Zinc ions coordinate the protein structure in a tetrahedral geometry binding to cystine-cystine or cysteines-histidine amino acids. ZFP’s unique enables it interact with wide variety of molecules including RNA; thus, ZFP modulates several processes host immune response and virus replication. ZFPs have shown their antiviral efficacy against DNA RNA viruses. However, role human coronavirus is little...
The purified Immunoglobulin G (IgG) is effectively used in passive immunization.There are various methods to isolate the IgG from serum, with its own advantages and disadvantages.In current study, a comparative efficacy of affinity chromatography using Protein A-Sepharose ion exchange DEAE Sephadex A50 was done regard yield purity IgG.Both were found equally effective isolation pure similar recovery, indicating that researcher can use either method purify depending on available resources.
Zinc finger CCCH containing 11A (ZC3H11A) is a stress-induced protein that upregulated in various conditions such as heat shock and virus infection. It has also been reported to be certain cancers. The aim of this study was evaluate the feasibility targeting ZC3H11A therapeutic approach for cancer treatment, using nuclease-resistant, affinity-enhanced antisense oligonucleotide (ASO). An ASO validated evaluated
In the current study, potential interaction mechanisms between capmatinib (CAP), a selective tyrosine kinase inhibitor, and calf thymus double-stranded DNA (ds-DNA) were evaluated.