A5015209221- Enzyme Catalysis and Immobilization
- Spectroscopy Techniques in Biomedical and Chemical Research
- Spectroscopy and Chemometric Analyses
- Analytical Chemistry and Chromatography
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Electronic and Structural Properties of Oxides
- Pesticide Residue Analysis and Safety
- Chemical synthesis and alkaloids
- Axial and Atropisomeric Chirality Synthesis
- Plant biochemistry and biosynthesis
- Surface Chemistry and Catalysis
- Semiconductor materials and devices
- Marine Toxins and Detection Methods
- Semiconductor Quantum Structures and Devices
- Inorganic and Organometallic Chemistry
- Hemoglobin structure and function
- Microbial Natural Products and Biosynthesis
- Chemical Synthesis and Analysis
- Identification and Quantification in Food
- Analytical Methods in Pharmaceuticals
- Microbial Metabolic Engineering and Bioproduction
- Asymmetric Hydrogenation and Catalysis
- Carbohydrate Chemistry and Synthesis
Agilent Technologies (United Kingdom)
2018
Cobalt Institute
2014-2017
University of Bath
2011-2014
Abingdon Community Hospital
2014
Centre for Sustainable Energy
2013
Abstract Major food adulteration incidents occur with alarming frequency and are episodic, the latest incident, involving of meat from 21 producers in Brazil supplied to 60 other countries, reinforcing this view. Food fraud counterfeiting involves all types foods, feed, beverages, packaging, potential for serious health, as well significant economic social impacts. In spirit drinks sector, counterfeiters often ‘recycle’ used genuine or employ good quality simulants. To prove that suspect...
Microbial ipso,ortho-dihydroxylation of benzoic acid by the B9 mutant strain Ralstonia eutropha permits rapid construction aminocyclitols containing a quaternary stereocentre. Installation amine functionality is achieved use an acylnitroso dienophile for hetero-Diels–Alder reaction. Both aminotetrols and aminohexols are accessible as single enantiomers this route. NOESY spectroscopic X-ray crystallographic analyses were required to distinguish cycloadduct isomers. Notably, subsequent...
Transmission Raman spectroscopy (TRS) is a recently introduced analytical technique to pharmaceutical analysis permitting volumetric sampling by non-destructive means. Here we demonstrate experimentally, for the first time, enhanced speed of quantification tablets an order magnitude compared with conventional TRS. This achieved using enhancing element, "photon diode", avoiding loss laser photons at coupling interface. The proof-of-concept experiments were performed on complex mixture...
Metabolism of meta-bromobenzoic acid by the blocked mutant Ralstonia eutrophus B9 affords an enantiopure dearomatised halodiene-diol which we demonstrate is a versatile chiron for organic synthesis. The presence halogen leads to reactivity that distinct observed non-halogenated analogue and also serves as synthetic handle further functionalisation.
Oxidation of benzoic acid by a microorganism expressing benzoate dioxygenase leads to the formation an unusual<italic>ipso</italic>,<italic>ortho</italic>arene<italic>cis</italic>-diol in sufficient quantities be useful for synthesis.