A5056060581- biodegradable polymer synthesis and properties
- Advanced Polymer Synthesis and Characterization
- Nanoparticle-Based Drug Delivery
- Carbon dioxide utilization in catalysis
- Advanced Drug Delivery Systems
- Nanoplatforms for cancer theranostics
- Antimicrobial agents and applications
- 3D Printing in Biomedical Research
- Enzyme Catalysis and Immobilization
- RNA Interference and Gene Delivery
- Innovative Microfluidic and Catalytic Techniques Innovation
- Additive Manufacturing and 3D Printing Technologies
- Polymer Surface Interaction Studies
- Synthetic Organic Chemistry Methods
- Nanofabrication and Lithography Techniques
- Dendrimers and Hyperbranched Polymers
- Bacterial biofilms and quorum sensing
- Graphene and Nanomaterials Applications
- Polymer Foaming and Composites
- Lichen and fungal ecology
- Glioma Diagnosis and Treatment
- Electrospun Nanofibers in Biomedical Applications
- Hydrogels: synthesis, properties, applications
- Polymer composites and self-healing
- Chemical Synthesis and Reactions
University of Nottingham
2016-2025
Park University
2016-2021
Engineering and Physical Sciences Research Council
2017
AstraZeneca (United Kingdom)
2017
Sapienza University of Rome
2013-2016
Animal models are effective for assessing tumor localization of nanosystems but difficult to use studying penetration beyond the vasculature. Here, we have used well-characterized HCT116 colorectal cancer spheroids study effect nanoparticle (NP) physicochemical properties on and uptake. Incubation with Hoechst 33342 resulted in a dye gradient, which facilitated discrimination between populations cells core at periphery by flow cytometry. This approach was compare doxorubicin liposomal...
Poly (glycerol adipate) (PGA) can be produced from divinyl adipate and unprotected glycerol by an enzymatic route to generate a polymer with relatively low molar mass (12 kDa). PGA bears pendant hydroxyl group which imparts hydrophilic character this water insoluble polymer. We have examined the effect of synthesis temperature on characteristics through various techniques including FT-IR, 1H 13C NMR, surface thermal analysis, both expand data already present in literature about material...
Abstract Research into advanced therapeutic materials is of growing importance worldwide, particularly in the disease areas infection, neurodegeneration, and oncology. Advances have been made treating these diverse pathologies but there still remain many challenging areas. Amongst most difficult are those involving highly potent and/or cytotoxic agents which present inherent problem adverse off‐target effects. Of key to widen window for such by reducing access non‐diseased cells enhancing...
Glioblastoma is a malignant brain tumour with median survival of 14.6 months from diagnosis. Despite maximal surgical resection and concurrent chemoradiotherapy, reoccurrence inevitable. To try combating the disease at stage low residual burden immediately post-surgery, we propose localised drug delivery system comprising spray device, bioadhesive hydrogel (pectin) nanocrystals coated polylactic acid-polyethylene glycol (NCPPs), to be administered directly into parenchyma adjacent cavity. We...
Sustainably derived poly(glycerol adipate) (PGA) has been deemed to deliver all the desirable features expected in a polymeric scaffold for drug-delivery, including biodegradability, biocompatibility, self-assembly into nanoparticles (NPs) and functionalisable pendant group. Despite showing these advantages over commercial alkyl polyesters, PGA suffers from series of key drawbacks caused by poor amphiphilic balance. This leads weak drug-polymer interactions subsequent low drug-loading NPs,...
A robust methodology is presented to identify novel biomaterials suitable for three-dimensional (3D) printing. Currently, the application of additive manufacturing limited by availability functional inks, especially in area biomaterials; this first time when method used tackle problem, allowing hundreds formulations be readily assessed. Several properties, including release an antidepressive drug (paroxetine), cytotoxicity, and printability, are screened 253 new ink a high-throughput format...
There is an increasing need to develop bio-compatible polymers with increased range of different physicochemical properties. Poly(glycerol-adipate) (PGA) a biocompatible, biodegradable amphiphilic polyester routinely produced from divinyl adipate and unprotected glycerol by enzymatic route, bearing hydroxyl group that can be further functionalized. Polymers average Mn ∼13 kDa synthesized without any post-polymerization deprotection reactions. Acylated fatty acid chain length C4, C8, C18...
The problem of predicting small molecule-polymer compatibility is relevant to many areas chemistry and pharmaceutical science but particularly drug delivery. Computational methods based on Hildebrand Hansen solubility parameters, the estimation Flory–Huggins parameter, χ, have proliferated across literature. Focusing need develop amorphous solid dispersions improve bioavailability poorly soluble candidates, an innovative, high-throughput 2D printing method has been employed rapidly assess 54...
We now report the synthesis of well-defined terpene-based polymers and precise di- multiblock copolymer architectures by use RAFT, wide range <italic>T</italic><sub>g</sub> promising adhesive properties are observed.
This study aimed to improve the anticancer effect of Cordyceps militaris herbal extract (CME) on breast cancer cells with hyaluronic acid (HYA) surface-decorated lipid polymer hybrid nanoparticles (LPNPs) and evaluate applicability a synthesized poly(glycerol adipate) (PGA) for LPNP preparation. Firstly, cholesterol- vitamin E-grafted PGA polymers (PGA-CH PGA-VE, respectively) were fabricated, without maleimide-ended polyethylene glycol. Subsequently, CME, which contained an active...
Presented in this work is the use of a molecular descriptor, termed α parameter, to aid design series novel, terpene-based, and sustainable polymers that were resistant biofilm formation by model bacterial pathogen Pseudomonas aeruginosa. To achieve this, potential range recently reported, terpene-derived monomers deliver resistance when polymerized was both predicted ranked application parameter key features their structures. These derived from commercially available terpenes (i.e.,...
We investigated how the biodistribution of cannabidiol (CBD) within central nervous system (CNS) is influenced by two different formulations, an oil-in-water (O/W) nanoemulsion and polymer-coated nanoparticles (PCNPs). observed that both CBD formulations administered were preferentially retained in spinal cord, with high concentrations reaching brain 10 min administration. The reached Cmax at 210 ng/g 120 (Tmax), whereas PCNPs had a 94 30 indicating rapid delivery can be achieved through use...
This study explored the co-delivery of curcumin (CUR) and resveratrol (RV) using folic acid-conjugated poly(glycerol adipate)-based nanoparticles (FPPC NPs) to enhance their synergistic anticancer effects against osteosarcoma. Based on toxicity experiments Saos-2 cells, optimal CUR:RV ratios were 1:2 1:3, which used for co-encapsulation. Increasing amount RV in co-loaded NPs did not affect properties nanocarriers, but predominantly increased loading capacity RV, especially at 1:3 ratio, by...
Reported herein is the first combination of resonant acoustic mixing (RAM) and controlled ring-opening polymerization (ROP) to deliver fully sustainable, end-functionalized, biodegradable polymers via a manufacturing route with much-reduced environmental impact. This includes successful use agriculturally sourced functionalized initiators (terpene alcohols) in ROP synthesis cyclic esters generate an array novel, polyesters applicable numerous biomedical applications, such as drug delivery....
Many new active pharmaceutical ingredients (APIs) demonstrate high hydrophobicity and low water-solubility issues. In this regard, polymeric nanoparticles (NPs) have been extensively used as drug delivery carriers for the encapsulation of such APIs. One commonly polymer is polyethylene glycol (PEG), owing to its biocompatibility, water solubility, capacity prolong residence time. However, concerns arisen regarding PEG's immunogenicity limited biodegradability. addition, inherent limitations,...
A facile and green photocatalytic approach to obtain highly pure α-pinene, allowing total utilization of turpentine as a biomass resource.
Usnic acid, a potent antimicrobial and anticancer agent, poorly soluble in water, was complexed to novel polyacrylamides by establishment of strong acidic-base interactions. Thermal spectroscopic analysis evidenced molecular dispersion the drug polymers complete drug/polymer miscibility for all tested compositions. The polymer/drug complexes promptly dissolved water possessed greater activity against Staphylococcus epidermidis than both free polymer alone. best results were obtained with...