A5064309015- Surfactants and Colloidal Systems
- Supramolecular Self-Assembly in Materials
- Lipid Membrane Structure and Behavior
- Supramolecular Chemistry and Complexes
- Protein Interaction Studies and Fluorescence Analysis
- Electrostatics and Colloid Interactions
- Drug Transport and Resistance Mechanisms
- Crystallization and Solubility Studies
- Nanoparticle-Based Drug Delivery
- Analytical Chemistry and Chromatography
- X-ray Diffraction in Crystallography
- Advanced Polymer Synthesis and Characterization
- Polydiacetylene-based materials and applications
- Mesoporous Materials and Catalysis
- Molecular Sensors and Ion Detection
- Porphyrin and Phthalocyanine Chemistry
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Metal-Organic Frameworks: Synthesis and Applications
- Enzyme Structure and Function
- Hydrogels: synthesis, properties, applications
- Neonatal Health and Biochemistry
- Carbohydrate Chemistry and Synthesis
- Crystallography and molecular interactions
- Advanced biosensing and bioanalysis techniques
Sapienza University of Rome
2016-2025
Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase
2023
University of Bari Aldo Moro
2018-2020
Universidade de Santiago de Compostela
2006-2013
Universidad de Costa Rica
2013
European Molecular Biology Laboratory
2009
Istituto di Metodologie Chimiche
1996-2005
Istituto Superiore di Sanità
2004-2005
University of L'Aquila
1998-2000
Slovak University of Technology in Bratislava
1999
Bile salts (BSs) are naturally occurring rigid surfactants with a steroidal skeleton and specific self-assembly interface behaviors. Using bile as precursors, derivatives can be synthesized to obtain molecules functionalities amphiphilic structure. Modifications on single normally performed by substituting the least-hindered hydroxyl group carbon C-3 of A ring or at end lateral chain. This leads monosteroidal building blocks that often able self-organize into 1D structures such tubules,...
This study investigates the performance of two non-ionic sugar-based surfactants, belonging to families synthetic alkylpoliglucosides and biological rhamnolipids, for enhancing solubilization mass transfer strongly adsorbed hydrophobic organic compounds (HOCs) in porous media. Using toluene perchloroethylene (PCE) as reference pollutants, a continuous configuration test (column experiment) was performed simulate soil flushing process under controlled laboratory conditions. The potential...
Plasmonically enhanced optical dichroism has attracted substantial interest for its application in sensing, where the interplay between chirality emanating from both molecules and plasmon-supporting structures been regarded as a critical ingredient. Here, we experimentally demonstrate that suitably self-assembled achiral plasmonic nanostructures produce high degree of enhancement observed chiral placed their vicinity. Specifically, identify near-field associated with hotpots mechanism...
Sustainably derived poly(glycerol adipate) (PGA) has been deemed to deliver all the desirable features expected in a polymeric scaffold for drug-delivery, including biodegradability, biocompatibility, self-assembly into nanoparticles (NPs) and functionalisable pendant group. Despite showing these advantages over commercial alkyl polyesters, PGA suffers from series of key drawbacks caused by poor amphiphilic balance. This leads weak drug-polymer interactions subsequent low drug-loading NPs,...
The interactions between three β-cyclodextrin hosts (having 1−3 binding sites) and two adamantyl guests 1−2 have been studied by ITC, ROESY, static dynamic light scattering (SLS DLS), AFM TEM techniques. enthalpy free energy values (determined from ITC experiments) evidence that the single interaction one site of guest host is independent number sites interacting species. average are ΔH° = −26.6 ± 2.3 kJ mol-1 ΔG° −30.4 3.2 mol-1, indicating process mainly driven. In all cases, experimental...
The formation of supramolecular structures initiated by a p-tert-butylphenyl-amide derivative cholic acid is investigated. initial spherical vesicles, with rather low effective bending constant, collapse into necklaces that self-transform tubules small diameter. Finally, molecular tubes are generated (see figure). During the process, geometrical constraints fixed surface area and enclosed volume obeyed.
A structural comparison between the Normal and Expanded isomers of human serum albumin has been carried out by using small angle X-ray scattering (SAXS) light (LS) techniques. Geometrical bodies, recovered structures (GA_STRUCT code) rigid body modeling (CRYSOL BUNCH software) were used to obtain low-resolution 3D from one-dimensional patterns. These restored shapes also exploited perform a correlation SAXS LS data. By attempting detailed description globular unfolded protein in solution, we...
The positive charge on liposome surface is known to promote the crossing of Blood brain barrier (BBB). However, when diastereomeric cationic gemini amphiphiles are among lipid membrane components, also stereochemistry may affect permeability vesicle across BBB.Liposomes featuring diasteromeric were formulated, characterized, and their interaction with cell culture models BBB investigated.Liposomes internalized in a monolayer microvascular endothelial cells derived from human induced...
Balancing the positives and negatives: A new behavior in field of catanionic mixtures was observed solutions anionic cationic forms rigid non-conventional amphiphiles. Dilute aqueous bile salt derivatives form tubules with charge ranging from negative to positive values depending on surfactant molar ratio mixtures. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted...
Inorganic nanoparticle–chiral molecule coupling may produce chiroptical effects at the inorganic particles' excitation wavelengths. In this work, we demonstrate that low concentrations of glutathione molecules adsorbed to cube-shaped silver nanoparticles lead appearance new circular dichroism signals in plasmon resonance absorption range. Moreover, for pH values <4.5, nanoparticle surface promotes reversible thiol group oxidation, leading formation diglutathione and consequent modification...
Abstract An approach for tailoring self‐assembled tubular structures is described. By controlling the relative composition of a two‐component surfactant mixture comprising natural bile salt lithocholate and its bolamphiphilic derivative, it was possible to finely tune nanotube cross‐section mixed aggregates that self‐associated spontaneously in aqueous solution at pH 12. The diameter found vary up 50 % when stoichiometric ratio two salts changed. tuning supramolecular nanochannels with such...
A comprehensive experimental study on the interaction between PEO-PPO-PEO block copolymer P123 (EO20PO68EO20) and anionic bile salt sodium glycodeoxycholate (NaGDC) in water has been performed. The work was aimed at investigating suitability of using as sequestrant beside fundamental aspects copolymer-bile interactions. Various techniques including dynamic static light scattering, small-angle X-ray differential scanning calorimetry (DSC) were employed combination with electrophoretic...
Nature suggests that complex materials result from a hierarchical organization of matter at different length scales. At the nano- and micrometer scale, macromolecules supramolecular aggregates spontaneously assemble into supracolloidal structures whose complexity is given by coexistence various colloidal entities specific interactions between them. Here, we demonstrate how such control can be implemented engineering specially customized bile salt derivative-based tubules exhibit highly...
Condensation of DNA helices into hexagonally packed bundles and toroids represents an intriguing example functional organization biological macromolecules at the nanoscale. The condensation models are based on unique polyelectrolyte features DNA, however here we could reproduce a DNA-like with supramolecular small chiral molecules, thereby demonstrating that it is more general phenomenon. We show bile salt sodium deoxycholate can form upon interaction oppositely charged polyelectrolytes...
The fabrication of enzyme-based biosensors has received much attention for their selectivity and sensitivity. In particular, laccase-based have attracted a lot interest capacity to detect highly toxic molecules in the environment, becoming essential tools fields white biotechnology green chemistry. manufacturing new, metal-free, biosensor with unprecedented reuse storage capabilities been achieved this work through application electrospray deposition (ESD) methodology as enzyme...
Ru( ii ) complexes featuring two π-expansive benzo[ i ]dipyrido[3,2- a :2′,3′- c ]phenazine ligands are potent photosensitizers that can be encapsulated into cubosomes to achieve hybrid formulations with augmented biopharmaceutical properties.
Many new active pharmaceutical ingredients (APIs) demonstrate high hydrophobicity and low water-solubility issues. In this regard, polymeric nanoparticles (NPs) have been extensively used as drug delivery carriers for the encapsulation of such APIs. One commonly polymer is polyethylene glycol (PEG), owing to its biocompatibility, water solubility, capacity prolong residence time. However, concerns arisen regarding PEG's immunogenicity limited biodegradability. addition, inherent limitations,...
Cubosomes are non-lamellar lipid nanoparticles that have drawn a significant attention in the field of nanomedicine due to their tunable properties. However, formation vesicles during preparation cubosomes, and presence mixed bicontinuous cubic phases, may lead artifacts lack correlation between physico-chemical biological characterization. In this work, we formulated cubosomes composed by monoolein as building block triblock copolymer Pluronic® F108 stabilizer, encapsulating three porphyrin...
Two-dimensional covalent organic frameworks (2D COFs) are periodic, permanently porous, lightweight solids with remarkable structural modularity, enabling precise control over their properties. As thin films, they have shown promising applications in chemical separations and electronics, making it crucial to understand stability under mechanical stress. Here, we investigate how two different linkages commonly used for 2D COFs, specifically imine enamine, influence the properties of nanoscale...
Supramolecular structures controlled by the delicate balance between bile salt self-assembly and geometric characteristics of block copolymer.
We report a kinetic study of the supramolecular tubule formation bile salt derivative [3β,5β,7α,12α]-3-(4-t-butylbenzoilamine)-7,12-dihydroxycholan-24-oic acid sodium (Na-tbutPhC). At high bicarbonate buffer concentration (pH∼10) this shows gelator properties. Starting from gels or viscous solutions, is triggered by increasing temperature beyond critical value 34–36 °C. For gels, when process takes place, transition to sols occurs. The easily and can be followed several techniques. used...