A5081287326- Oxidative Organic Chemistry Reactions
- Lipid Membrane Structure and Behavior
- Synthesis of β-Lactam Compounds
- Synthesis and Catalytic Reactions
- Radical Photochemical Reactions
- Supramolecular Self-Assembly in Materials
- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- Supramolecular Chemistry and Complexes
- Advanced biosensing and bioanalysis techniques
- Molecular Junctions and Nanostructures
- Electrochemical sensors and biosensors
- Porphyrin and Phthalocyanine Chemistry
- Chemical Synthesis and Reactions
- Chemical Synthesis and Analysis
- Inorganic and Organometallic Chemistry
- Crystallization and Solubility Studies
- Perovskite Materials and Applications
- Synthesis and Biological Activity
- X-ray Diffraction in Crystallography
- Conducting polymers and applications
- Luminescence and Fluorescent Materials
- Analytical Chemistry and Sensors
- Molecular Sensors and Ion Detection
- Synthesis of heterocyclic compounds
Sapienza University of Rome
2014-2024
Istituto di Metodologie Chimiche
2005-2011
Institute of Molecular Biology and Pathology
2005
University of Bologna
2000
University of Salerno
1995
In this work, bile acids-amino acids, L-proline and L-phenylalanine, conjugates acids amino derivatives were successfully synthesized, characterized employed as organocatalysts for direct asymmetric aldol reactions in aqueous medium. Bile exhibited high catalytic activity, with the L-proline-based organocatalyst showing highest efficiency, achieving yields up to 99%, diastereoselectivity anti product moderate enantioselectivity. The L-phenylalanine-based one demonstrated good performance,...
Cubosomes are non-lamellar lipid nanoparticles that have drawn a significant attention in the field of nanomedicine due to their tunable properties. However, formation vesicles during preparation cubosomes, and presence mixed bicontinuous cubic phases, may lead artifacts lack correlation between physico-chemical biological characterization. In this work, we formulated cubosomes composed by monoolein as building block triblock copolymer Pluronic® F108 stabilizer, encapsulating three porphyrin...
4-Methyl-5-alkyl-2(5H)-furanones have been prepared by ruthenium-catalyzed ring-closing metathesis of the suitable methallyl acrylates. Despite electron deficiency conjugated double bond and gem-disubstitution allylic alkene moiety in starting acrylates, first-generation Grubbs' catalyst I proved to be an effective promoter for ring closure, affording expected butenolides good high yields.
The realization of a reliable receptor biosensor requires stable, long-lasting, reconstituted biomembranes able to supply suitable biomimetic environment where the can properly work after incorporation. To this end, we developed new method for preparing stable biological membranes that couple properties BLMs (bilayer lipid membranes) with high stability HBMs (hybrid bilayer membranes); gives rise an innovative assembly, named MHBLM (mixed hybrid membrane). present deals characterization...
Sodium lauryl ether sulfates (SLES) are a class of surfactants, among the most used in formulations healthcare products. Although largely industry, literature studies hereto completely missing characterization some species, as sodium triether (E3S), and effect several assembly parameters, temperature. Moreover, drastic disparity performance subsists laboratory synthesized industrial raw SLES, generating problems real-world applications design. We report on self-assembly analysis grade...
The chiral bile salt sodium cholate has been covalently linked to tetra-aryl-porphyrins, conferring them an extrinsic chirality and obtaining new molecules with high tendency aggregate in solution. transfer from the molecular nano- meso-scale investigated by promoting self-assembly of conjugates balancing ratio aqueous/organic solvent mixtures allowing a fine control dimensions morphology final supramolecular architectures. shift elongated structures helical ribbon features monodisperse...
The ring-closing metathesis (RCM) reactions of homoallylic acrylates bearing alkyl substituents on various positions their skeleton afford the corresponding pentenolides in presence carbene ruthenium catalysts. For R3 = R4 H, or Me, are catalyzed by complex [RuCl2(PCy3)2(=CHPh)], while a second-generation Grubbs catalyst is required when H and i-Pr H. Alkyl substitution at carbon (R1, R2) increases yield reaction both acrylic and/or double bonds methyl-substituted. interaction with substrate...
An amino acid-substituted bile acid forms tubular aggregates with inner and outer diameters of about 3 6 nm. The are unusually small for surfactant self-assembled tubes. results enhance the spectrum applications supramolecular tubules open up possibilities investigating a novel class biological amphiphiles.
Biocompatible molecules that undergo self-assembly are of high importance in biological and medical applications nanoscience. Peptides bile acids among the most investigated due to their ability self-organize into many different, often stimuli-sensitive, supramolecular structures. With aim preparing mixing aggregation properties acid amino acid-based molecules, we report on synthesis self-association behavior two diastereomers obtained by substituting a hydroxyl group cholic with...
The introduction of a mannose residue on carbon 3 lithocholic acid gives rise to an asymmetric and rigid bolaamphiphilic molecule, which self-assembles in water form elongated tubular aggregates with outer diameter about 20 nm. These structures display temporal evolution, where the average tube decreases time, can be followed by time-resolved small-angle X-ray scattering experiments. Cryogenic transmission electron microscopy images collected as function time show that at short times after...
The immobilization of ferrocene's amino derivatives onto carboxyl-functionalized multiwalled carbon nanotubes (MWCNTs−COOH) electrodes has been carried out to test the ability ion reactive landing procedure realize chemically modified electrodes. ionic species involved in were structurally and energetically characterized by joint application collisionally induced dissociation mass spectrometry theoretical calculations. Furthermore, surface was analyzed spectroscopic voltammetric techniques...
Self-assembly of peptides and bile acids has been widely investigated because their biological role potential as a tool for the preparation nanostructured biomaterials. We herein report both synthesis self-association behavior compound that combines aggregation properties acid- amino acid-based molecules. The derivative prepared by introducing L-tryptophan residue into C-3 position deoxycholic acid skeleton resulted in an amphoteric fluorescent labeled shows pH-dependent self-assembly. Under...
α,β-Unsaturated γ- and δ-lactones are important classes of five- six-membered heterocycles largely present in biologically active compounds natural unnatural origin, for which the ring-closing metathesis approach has disclosed simplified synthetic strategies en route or final step toward target molecules. Following from early examples formation macrolide rings, this account describes RCM reactions allyl homoallyl acrylic esters promoted by different ruthenium carbene catalysts, shows how...
This paper reports the preparation and characterization of an Au electrode modified with self-assembled alkane ferrocenes, in absence presence beta-cyclodextrins (betaCD). Electrode modification ferrocene derivatives was achieved through a monolayer (SAM) approach, using ferrocenyl hexane thiol (FcC6) undecane (FcC11); same also done per-6-thio-beta-cyclodextrin. The different SAMs prepared were characterized by both cyclic voltammetry electrochemical surface plasmon resonance (EC-SPR)....
The elusive hydroxylammonium lead iodide NH<sub>3</sub>OHPbI<sub>3</sub> has been successfully synthesized and characterized for the first time.