A5055284944- Innovative Microfluidic and Catalytic Techniques Innovation
- Bacterial biofilms and quorum sensing
- Antimicrobial agents and applications
- Chemical Synthesis and Analysis
- 3D Printing in Biomedical Research
- Advanced Polymer Synthesis and Characterization
- Biosensors and Analytical Detection
- Pickering emulsions and particle stabilization
- Surfactants and Colloidal Systems
- biodegradable polymer synthesis and properties
- Urinary Bladder and Prostate Research
- Antibiotic Use and Resistance
- Enterobacteriaceae and Cronobacter Research
- Inhalation and Respiratory Drug Delivery
- Silicone and Siloxane Chemistry
- Bacterial Identification and Susceptibility Testing
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Obesity and Health Practices
- Analytical chemistry methods development
- RNA Interference and Gene Delivery
- Polymer Surface Interaction Studies
- Multicomponent Synthesis of Heterocycles
- Additive Manufacturing and 3D Printing Technologies
- Antibiotic Resistance in Bacteria
University of Nottingham
2017-2025
John Wiley & Sons (United Kingdom)
2022
Interface (United Kingdom)
2022
Faculty (United Kingdom)
2019
Engineering (Italy)
2019
Innovative approaches to prevent catheter-associated urinary tract infections (CAUTIs) are urgently required. Here, we describe the discovery of an acrylate copolymer capable resisting single- and multispecies bacterial biofilm formation, swarming, encrustation, host protein deposition, which major challenges associated with preventing CAUTIs. After screening ~400 polymers, poly(tert-butyl cyclohexyl acrylate) was selected for its biofilm- encrustation-resistant properties. When combined...
Bacterial infections in healthcare settings are a frequent accompaniment to both routine procedures such as catheterization and surgical site interventions. Their impact is becoming even more marked the numbers of medical devices that used manage chronic health conditions improve quality life increases. The resistance pathogens multiple antibiotics also increasing, adding an additional layer complexity problems employing safe effective procedures. One approach reducing rate associated with...
Presented in this work is the use of a molecular descriptor, termed α parameter, to aid design series novel, terpene-based, and sustainable polymers that were resistant biofilm formation by model bacterial pathogen Pseudomonas aeruginosa. To achieve this, potential range recently reported, terpene-derived monomers deliver resistance when polymerized was both predicted ranked application parameter key features their structures. These derived from commercially available terpenes (i.e.,...
Synthetic materials are an everyday component of modern healthcare yet often fail routinely as a consequence medical-device-centered infections. The incidence rate for catheter-associated urinary tract infections is between 3% and 7% each day use, which means that infection inevitable when resident sufficient time. O'Neill Review on antimicrobial resistance estimates that, left unchecked, ten million people will die annually from drug-resistant by 2050. Development biomaterials resistant to...
Wound healing is a complex biological process involving close crosstalk between various cell types. Dysregulation in any of these processes, such as diabetic wounds, results chronic nonhealing wounds. Fibroblasts are critical type involved the formation granulation tissue, essential for effective wound healing. 315 different polymer surfaces screened to identify candidates which actively drive fibroblasts toward either pro- or antiproliferative functional phenotypes. Fibroblast-instructive...
A novel flow process to produce low-molecular-weight (Mwt) methacrylate oligomer mixtures that have potential as vaccine adjuvants and chain transfer agents (CTAs) is reported. The chemistry were designed significantly reduce the number of stages required manufacture methyl oligomer-in-monomer with an Mwt range dimers pentamers >50% conversion. Combining rapid in-flow, in situ catalytic polymerization catalyst synthesis volumetric microwave heating reaction medium resulted being completed...
Biomaterials are vital in medicine but can cause infections and poor tissue integration. This study developed poly(ethyl acrylate) surfactants to address these issues. These were used create 2D films 3D microparticles, analysed for their effects on biological response.
Abstract A flow‐focusing microfluidic device is used to produce functionalized monodisperse polymer particles with surface chemistries designed control bacterial biofilm formation. This achieved by using molecularly bespoke surfactants synthesized via catalytic chain transfer polymerization. novel approach of polymeric surfactants, often called surfmers, containing a biofunctional moiety contrasts the more commonly employed emulsion methods. Typically, chemistry microparticles are dominated...
A novel single-well prototype high throughput microwave reactor geometry has been produced and shown to be capable of synthesizing an array non-commercially available methacrylate monomers.
We report the first successful combination of three distinct high-throughput techniques to deliver accelerated design, synthesis, and property screening a library novel, bio-instructive, polymeric, comb-graft surfactants. These three-dimensional, surface-active materials were successfully used control surface properties particles by forming unimolecular deep layer on via microfluidic processing. This strategy deliberately utilizes surfactant both create stable desired cell-instructive...
We report on the ring-opening polymerization of ɛ-caprolactone incorporated with a magnetic susceptible catalyst, FeCl 3 , via use microwave heating (HH) which primarily heats bulk field (H-field) from an electromagnetic (EMF). Such process was compared to more commonly used methods, such as conventional (CH), i.e., oil bath, and electric (EH), is also referred that (E-field). identified catalyst both E-field H-field heating, promoted bulk. Which, we noticed promotion lot significant in HH...
Droplet microfluidics can produce highly tailored microparticles whilst retaining monodispersity. However, these systems often require lengthy optimisation, commonly based on a trial-and-error approach, particularly when using bio-instructive, polymeric surfactants. Here, micropipette manipulation methods were used to optimise the concentration of bespoke surfactants biodegradable (poly(d,l-lactic acid) (PDLLA)) with unique, bio-instructive surface chemistries. The effect three-dimensional...
This study reports the development of first copolymer material that (i) is resistant to fungal attachment and hence biofilm formation, (ii) operates via a nonkilling mechanism, i.e., avoids use antifungal actives emergence resistance, (iii) exhibits sufficient elasticity for in flexible medical devices, (iv) suitable 3D printing (3DP), enabling production safer, personalized devices.
This report details the first systematic screening of free-radical-produced methacrylate oligomer reaction mixtures as alternative vaccine adjuvant components to replace current benchmark compound squalene, which is unsustainably sourced from shark livers. Homo-/co-oligomer methyl, butyl, lauryl, and stearyl were successfully synthesized using catalytic chain transfer control, where use microwave heating was shown promote propagation over transfer. Controlling mixture material properties...
The chemical analysis of microparticles is challenging due to the need mount particles on a substrate for analysis; double‐sided adhesive tape often used (sometimes conductive), however that usually coated with poly (dimethyl siloxane) (PDMS) as release agent. PDMS common surface contamination can mask chemistries and hinder material performance where it dependent this contaminated interface. It known contains very mobile oligomeric fraction readily diffuses across surfaces resulting in...