To determine the impact of metabolic syndrome (MetS) and/or dysfunction-associated fatty liver disease (MAFLD), which are pathophysiologically similar and include insulin resistance, on development new-onset cardiovascular with without type 2 diabetes according to sex.This study included 570,426 individuals a history who were enrolled in nationwide claims database from 2008 2016 classified by presence or absence MetS MAFLD stratified sex. The index was used that required diagnosis MAFLD....

Although conventional interventions for people at high risk of developing type 2 diabetes are usually conducted face-to-face, such burdensome health care providers. We developed a lifestyle intervention program combining coaching via smartphone application augmented by intermittently scanned continuous glucose monitoring without burdening Its effectiveness glycemic control and body weight reduction in was investigated.

OBJECTIVE To determine associations of systolic blood pressure (SBP) and diastolic (DBP) with new-onset coronary artery disease (CAD) or cerebrovascular (CVD) according to glucose status. RESEARCH DESIGN AND METHODS Examined was a nationwide claims database from 2008 2016 on 593,196 individuals. A Cox proportional hazards model identified risks CAD CVD events among five levels SBP DBP. RESULTS During the study period 2,240 3,207 occurred. Compared ≤119 mmHg, which lowest quintile SBP, hazard...

Abstract Purpose To determine the degree of control multiple risk factors under real-world conditions for coronary artery disease (CAD) according to presence or absence diabetes mellitus (DM) and whether reaching multifactorial targets blood pressure (BP), low-density lipoprotein-cholesterol (LDL-C), HbA1c, current smoking is associated with lower risks CAD. Methods We investigated effects on subsequent CAD number controlled among BP, LDL-C, in a prospective cohort study using nationwide...

Background Evidence of the role systolic blood pressure ( SBP ) in development severe diabetic retinopathy is not strong, although adverse effect low diastolic has been a partial explanation. We assessed predictive ability incident between pulse PP which considers both and pressure, compared with . Methods Results Eligible patients (12 242, 83% men) aged 19 to 72 years from nationwide claims database were analyzed for median observational 4.8‐year period. Severe was defined as...

Since the combined effects of proteinuria and a moderately decreased eGFR on incident severe eye complications in patients with diabetes are still largely unknown, these associations were determined large historical cohort Japanese mellitus.We evaluated overt (OP) (dipstick 1+ over) and/or reduced estimated glomerular filtration rate (eGFR) (MG) (baseline 30.0-54.9 mL/min/1.73 m2) incidence treatment-required diabetic diseases (TRDED). We divided 7709 into four groups according to presence...

To examine the independent and combined associations of cardiorespiratory fitness (CRF) muscular (MF) with cardiometabolic risk factors in Japanese adolescents.A cross-sectional study including 993 adolescents (aged 13-14 years) was undertaken. Height, body mass, blood pressure, lipid profile (non-fasting), HbA1c were measured. The physical (PF) test included measurements CRF (20 m multistage shuttle run test), upper limb strength (hand grip strength), lower (standing long jump), endurance...

Abstract Background The prevalence of diabetes is rising, and develops at a younger age in East Asia. Although lower limb amputation negatively affects quality life increases the risk cardiovascular events, little known about rates predictors among persons with from young adults to those “young‐old” category (50–72 y). Methods We analyzed data nationwide claims database Japan accumulated 2008 2016 involving 17,288 people aged 18–72 y (mean 50.2 y, HbA1c 7.2%). Amputation occurrence was...

Abstract Aims To determine incidence and predictors of starting dialysis in patients with diabetes emphasizing blood pressure variables. Methods A nationwide database claim data on 18 935 people (15 789 men 3146 women) mellitus aged 19 to 72 years Japan was used elucidate for dialysis. Initiation determined from claims using ICD‐10 codes medical procedures. Using multivariate Cox modelling, interactions between glycaemic values were determined. Results During a median follow‐up 5.3 years,...

Abstract Background Although both a history of cerebrovascular disease (CVD) and glucose abnormality are risk factors for CVD, few large studies have examined their association with subsequent CVD in the same cohort. Thus, we compared impact prior status, combinations on using real-world data. Methods This is retrospective cohort study including 363,627 men aged 18–72 years followed ≥ 3 between 2008 2016. Participants were classified as normoglycemia, borderline glycemia, or diabetes defined...

Abstract Aims Obesity and hepatic fat accumulation diminish insulin clearance, which can cause hyperinsulinaemia. Sodium/glucose‐cotransporter 2 inhibitors (SGLT2‐is) improve resistance hyperinsulinaemia by weight loss via increased urinary glucose excretion in type diabetes. However, there are few reports of the influence SGLT2‐is on clearance. We examined impact an SGLT2‐i clearance explored clinical associated with changes mechanism effects SGLT2‐i. Materials methods Data were analysed...

The aim of this study was to determine the association dental health behavior with awareness, oral condition, and subjective symptoms in Japan. present included 1699 individuals who underwent checkups at public center Miura City. All those were asked fill out a questionnaire. correlation between having regular dentist each other items analyzed. Undergoing significantly related dentist. To analyze Subjective Health structured equation modeling performed following factor analysis. As result,...

To determine associations between severity of hypertension and risk starting dialysis in the presence or absence diabetes mellitus (DM). A nationwide database with claims data on 258 874 people without DM aged 19-72 years Japan was used to elucidate impact dialysis. Initiation determined from using International Classification Diseases-10 codes medical procedures. Using multivariate Cox modeling, we investigated predict initiation DM. Hypertension significantly associated regardless The...

Type 2 diabetes (T2D) and prediabetes are well known to be associated with an increased risk of coronary artery disease (CAD). However, it remains unclear whether the magnitude effect traditional factors for cardiovascular on incidence CAD in those T2D differ from normoglycemic individuals. Thus, we compare influence (age, sex, BMI, SBP, HDLC, LDLC, HbA1c, estimated GFR, smoking, physical activity habit, antihypertensive drugs, hypolipidemic drug) according glucose tolerance status. Using a...

Although associations of the risk developing type 2 diabetes or cardiovascular disease with muscle strength, balance, flexibility were established separately, a comprehensive evaluation physical fitness is required. We previously developed composite measure these components designated as Physical ScoreTM and reported its significant prevalence diabetes, hypertension, dyslipidemia, fatty liver, metabolic syndrome (MetS). now examined longitudinal between PS incidence diseases.To calculate...

The leading cause of death in patients with steatotic liver disease (SLD) is CVD. As SLD frequently associated metabolic disorders such as type 2 diabetes (DM), the concept MASLD has been proposed. can be classified according to dysfunction. Among subtypes, DM (DM-MASLD) was shown have a major impact on development However, presence and status concomitant abnormalities change over time. Since it unclear how incidence CVD changes when DM-MASLD transitions, this study aimed clarify issue....

We previously determined cut-off values for MetS components to predict CVD and proposed newly optimized criteria in Japanese. Since status changes over time, we investigated associations between risk using current criteria. divided 201,007 men 99,579 women without prior into 4 groups according at 2 points (beginning end of baseline) during a 2-year baseline period (MetS-free, MetS-developed, MetS-remission, MetS-persisted). After baseline, incidence was followed up. Association incident...

Chronic kidney disease, HF, and type 2 diabetes mellitus (DM) are common interrelated. Although both low eGFR high have been associated with an increased risk of cardiovascular disease in patients DM, it is unclear whether this association differs according to glucose tolerance. Thus, we aimed clarify the between incidence new-onset HF tolerance status same cohort. Study participants underwent medical checkups 2008 2019. Based on they were divided into three groups (normoglycemia...