A5029002568- Sinusitis and nasal conditions
- Nasal Surgery and Airway Studies
- Head and Neck Surgical Oncology
- Allergic Rhinitis and Sensitization
- Nasolacrimal Duct Obstruction Treatments
- Ocular Surface and Contact Lens
- Obstructive Sleep Apnea Research
- Voice and Speech Disorders
- Asthma and respiratory diseases
- Neuroscience of respiration and sleep
- Eosinophilic Esophagitis
- Vasculitis and related conditions
- Otitis Media and Relapsing Polychondritis
- Glaucoma and retinal disorders
- Cancer and Skin Lesions
- Olfactory and Sensory Function Studies
- Respiratory and Cough-Related Research
- Occupational exposure and asthma
- Infectious Diseases and Mycology
- Pituitary Gland Disorders and Treatments
- Autoimmune and Inflammatory Disorders
- Cystic Fibrosis Research Advances
- Tracheal and airway disorders
- Dysphagia Assessment and Management
Humanitas University
2021-2025
IRCCS Humanitas Research Hospital
2021-2025
Casa di Cura Columbus
2024
GTx (United States)
2024
Objective The reboot approach could be an effective treatment option to lower recurrence rates (RRs) in recalcitrant Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). purpose of this study was investigate RR, recurrence‐free survival (RFS), quality life (QoL) improvement, and oral corticosteroid (OCS) intake pluri‐operated CRSwNP patients treated partial surgery. Methods A consecutive sample CRSwNP, ineligible for monoclonal antibodies, underwent 22‐item SinoNasal Outcome Test (SNOT‐22),...
In the last 20 years, growing interest in chronic rhinosinusitis (CRS) has become evident medical literature; nevertheless, it is still difficult to identify real prevalence of disease. Epidemiological studies are few and focused on heterogeneous populations diagnostic methods. Recent research contributed identifying CRS as a disease characterized by clinical scenarios, high impact quality life, elevated social costs. Patient stratification with phenotypes identification pathobiological...
Objective To provide real‐life evidence on long‐term radiological changes in patients with severe chronic rhinosinusitis nasal polyps (CRSwNP) treated dupilumab, and to assess possible differences between clinical results terms of endoscopic findings Patient‐Reported‐Outcomes (PROs). Methods Consecutive dupilumab for recalcitrant CRSwNP were required undergo CT scan at baseline (T0) after 12 (T1) since first administration. A group also performed 52 weeks (T2) outcomes. At each timepoint,...
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) often requires multiple treatments. When topical steroids prove insufficient, endoscopic sinus surgery (ESS) is the primary intervention. Among surgical options, reboot an innovative approach that offers potential for prolonged disease control in rapidly recurring cases, delaying need monoclonal antibody (mAb) therapy. Our study investigates histological and ultrastructural aspects of mucosal regeneration post‐reboot...
Objective: With just ten questions, the Berlin questionnaire (BQ) stands out as one of simplest and most widely implemented non-invasive screening tools for detecting subjects at high risk Obstructive Sleep Apnea (OSA), a still underdiagnosed syndrome characterized by partial or complete obstruction upper airways during sleep. The main aim this study was to enhance diagnostic accuracy BQ through Machine Learning (ML) techniques. Methods: A ML classifier (hereafter, ML-10) trained using...
Purpose: Although the effectiveness of molecular antibodies has been established, evidence is still lacking on objective predictors response. The aim this study was to assess whether extent previous endoscopic sinus surgeries, assessed by means Amsterdam Classification Completeness Endoscopic Sinus Surgery (ACCESS) score, may influence clinical outcomes in refractory CRSwNP patients treated with dupilumab. Materials and Methods: A consecutive sample dupilumab for previously operated...
Background: Medication overuse is an increasing global problem, especially for those rhinology diseases whose management requires over-the-counter drugs. This observational community pharmacy-based study aimed to investigate the actual use of best-selling topical nasal medications and characterize clinical issues underlying their query through pharmacist’s perception. Methods: In pilot phase, a preliminary survey was developed by team researchers tested on small sample practitioners assess...
Background: Anti-glaucoma eye drops have been investigated due to their production of fibrotic changes on the conjunctival surface, undermining functioning upper lacrimal drainage system. We aimed assess whether these effects may impair effectiveness endoscopic endonasal dacryocystorhinostomy (EE-DCR). Methods: This is a single-center observational retrospective study EE-DCR via posterior approach. Resolution epiphora and dacryocystitis were analyzed after 1 (T1) 6-months (T2) from surgery....
Given the high burden of olfactory dysfunction worldwide, recently increased due to COVID-19 pandemic, it is mandatory adopt a specific questionnaire assess impact impairment on quality life, be used in clinical practice. The aim this study adapt and validate short version Questionnaire Olfactory Disorders-Negative Statements (svQOD-NS) for Italian. In pilot phase, Italian (ITA-svQOD-NS) was produced following recommended guidelines. It then given 50 healthy subjects patients (affected by...
Clinical and demographic variables from all patients who underwent functional endoscopic sinus surgery (FESS) for CRSwNP in our Academic Hospital between 2013 2021 were retrospectively collected.The presence of first (mother, father, siblings) and/or second-degree (grandparents uncles) relatives, age disease onset, type-2 comorbidities (history atopic diseases, asthma, aspirin intolerance without N-ERD) assessed by a questionnaire.Overall familial link was defined when at least one relative...
In the era of precision medicine, target-therapy with monoclonal antibodies (mAb) has enabled new treatment options in patients affected by eosinophilic granulomatosis polyangiitis (EGPA). Nevertheless, sometimes unsatisfactory results at a nasal level may be observed. The aim this study is to describe reboot surgery as potential adjuvant strategy multi-operated, yet uncontrolled EGPA treated Mepolizumab. We performed on refractory CRSwNP. obtained clinical data, endoscopy, biopsy, and...
Chronic rhinosinusitis (CRS) and nasal septum deviation (SD) are two widely diffused clinical conditions in otorhinolaryngology practice. Albeit symptoms the most commonly referred by patients affected both conditions, recent evidence has explored impairment of function beyond its local implication. Indeed, prevalence psychiatric disorders, specifically anxiety depression, was found higher suffering from SD or CRS than general population. The aim this study to evaluate burden these terms...
The Berlin questionnaire (BQ), with its ten questions, stands out as one of the simplest and most widely implemented non-invasive screening tools for detecting individuals at a high risk Obstructive Sleep Apnea (OSA), still underdiagnosed syndrome characterized by partial or complete obstruction upper airways during sleep. main aim this study was to enhance diagnostic accuracy BQ through Machine Learning (ML) techniques. A ML classifier (hereafter, ML-10) trained using questions standard BQ....
Evaluation of effectiveness non-mucosa-sparing (eg, reboot) surgery in patients with chronic rhinosinusitis nasal polyps (CRSwNP), poorly responders to mAb therapy, who failed repeated comprehensive endoscopic surgeries.
Purpose of review Advances in understanding the molecular pathways underlying nasal epithelial inflammation have ushered era personalized medicine for chronic rhinosinusitis with polyps (CRSwNP). Research progress has led to approval several monoclonal antibodies (mAbs) severe CRSwNP, demonstrating promising outcomes both clinical trials and real-world settings. Similarly, evolution surgical techniques enhanced progression-free survival due development novel approaches. This narrative...
Abstract Purpose Topical anti-glaucoma medications have been investigated on producing fibrotic changes the conjunctival surface, undermining functioning of upper lacrimal drainage system. The aim study was to assess whether these effects may impair effectiveness dacryocystorhinostomy (DCR) in patients affected by both glaucoma and nasolacrimal duct obstructions (NLDO). Methods Single-center observational retrospective endoscopic endonasal-DCR (EE-DCR) via posterior approach. Consecutive...
Abstract Background: Endoscopic Sinus Surgery (ESS) failures are often due to the physiological deposition of fibrotic tissue determining post-surgical scars, stenosis and re-obliteration sinuses ostia, especially at level fronto-etmoidal sinusotomy middle meatus. Many efforts have been directed prevent it, with rarely satisfying results. The Jackson-Pratt (JP) is a suction catheter that limits body fluid collection near site surgery thanks its softness elasticity can be used in different...
Purpose: Glaucoma has been investigated on producing fibrotic changes the conjunctival surface, undermining functioning of upper lacrimal drainage system. The aim study was to assess whether these effects may impair effectiveness dacryocystorhinostomy (DCR) in patients affected by both glaucoma and nasolacrimal duct obstructions (NLDO). Methods: Single-center observational retrospective endoscopic endonasal-DCR (EE-DCR) via posterior approach. Consecutive were enrolled 2020–2023 evaluated...