A5023442045- Arsenic contamination and mitigation
- Parasites and Host Interactions
- Retinoids in leukemia and cellular processes
- Genomics and Phylogenetic Studies
- Genetics, Bioinformatics, and Biomedical Research
- Gut microbiota and health
- Parasite Biology and Host Interactions
- Microbial Community Ecology and Physiology
- Renal and related cancers
- Ion Transport and Channel Regulation
- Viral Infections and Vectors
- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Skin Protection and Aging
- Helicobacter pylori-related gastroenterology studies
- Computational Drug Discovery Methods
- Genetic Associations and Epidemiology
- Zoonotic diseases and public health
- Bioinformatics and Genomic Networks
- Therapeutic Uses of Natural Elements
- Malaria Research and Control
- vaccines and immunoinformatics approaches
- Photosynthetic Processes and Mechanisms
- Viral Infections and Outbreaks Research
- Microbial Metabolic Engineering and Bioproduction
Bethune-Cookman University
2014-2025
Jackson State University
2007-2023
Center for Environmental Health
2023
University of Puerto Rico-Mayaguez
2022
Southern University and Agricultural and Mechanical College
2022
Southeastern Universities Research Association
2022
Clark Atlanta University
2022
Morgan State University
2022
Ohio Supercomputer Center
2022
University of Ibadan
2021
Human schistosomiasis is a highly prevalent neglected tropical disease (NTD) caused by Schistosoma species. Research on the molecular mechanisms influencing outcomes of bladder infection haematobium urgently needed to develop new diagnostics, therapeutics and prevention strategies. The objective research study was determine microbiome features changes in urine during urogenital induced pathologies.Seventy participants from Eggua, southwestern Nigeria provided morning samples were screened...
Genes encoding proteins that contain the universal stress protein (USP) domain are known to provide bacteria, archaea, fungi, protozoa, and plants with ability respond a plethora of environmental stresses. Specifically in plants, drought tolerance is desirable phenotype. However, limited focused organized functional genomic datasets exist on drought-responsive plant USP genes facilitate their characterization. The overall objective investigation was identify diverse Expressed Sequence Tags...
Abstract Anuran amphibians undergo major morphological transitions during development, but the contribution of their markedly different life-history phases to macroevolution has rarely been analysed. Here we generate testable predictions for coupling versus uncoupling phenotypic evolution tadpole and adult phases, underlying expression genes related feature formation. We test these by combining evidence from gene in two distantly frogs, Xenopus laevis Mantidactylus betsileanus , with...
The genes that encode the universal stress protein (USP) family domain (pfam00582) aid survival of bacteria in specific host or habitat-induced conditions. Genome sequencing revealed genome Helicobacter pylori, a gastric cancer pathogen, typically contains one USP gene, while related helicobacters have two distinct genes. However, insights into functions Helicobacteraceae (Helicobacter and Wolinella) are still limited to inferences from large-scale sequencing. Thus, we combined...
The need for automated identification of a disease makes the issue medical biometrics very current in our society. Not all biometric tools available provide real-time feedback. We introduce gas discharge visualization (GDV) technique as one that have potential to identify deviations from normal functional state at early stages and real time. GDV is nonintrusive capture physiological psychoemotional status person different organs organ systems through electrophotonic emissions fingertips...
The influence of environmental chemicals including arsenic, a type 1 carcinogen, on the composition and function human-associated microbiota is significance in human health disease. We have developed suite bioinformatics visual analytics methods to evaluate availability (presence or absence) abundance functional annotations microbial genome for seven Pfam protein families: As(III)-responsive transcriptional repressor (ArsR), anion-transporting ATPase (ArsA), arsenical pump membrane (ArsB),...
Proteins that selectively transport water across the membranes of cells are recognized as important in normal functioning body systems vertebrates. There 13 known mammalian aquaporins (AQP0 to AQP12), some which have been shown unexpected cellular roles beyond transmembrane transport. The availability non-mammalian vertebrate animal models has potential provide insight into emergence diverse function aquaporins. domesticated chicken (Gallus gallus) is premier avian model for biological...
Vertebrate ectotherms such as reptiles provide ideal organisms for the study of adaptation to environmental thermal change. Comparative genomic and exomic studies can recover markers that diverge between warm cold adapted lineages, but genes are functionally related may be difficult identify. We here used a bioinformatics genome-mining approach predict identify functions suitable candidate in chicken. first established framework markers, then compiled literature on known adapt environment...
Metabolic fingerprinting analysis can offer insights into underlying reactions in a biological system; hence it is crucial to the understanding of disease pathogenesis and could provide useful tools for discovering biomarkers. We sought examine urine plasma metabolome individuals affected by urogenital schistosomiasis its associated-bladder pathologies.
The draft nuclear genome sequence of the snail-transmitted, dimorphic, parasitic, platyhelminth Schistosoma mansoni revealed eight genes encoding proteins that contain Universal Stress Protein (USP) domain. is a causative agent human schistosomiasis, severe and debilitating Neglected Tropical Disease (NTD) poverty, which endemic in at least 76 countries. availability sequences species presents opportunities for bioinformatics genomics analyses associated gene families could be targets...
Breast cancer is the second leading cause of cancer-related deaths in women. Triple negative breast (TNBC) an aggressive subtype that affects 10-25% mostly African American TNBC has poorest prognosis all subtypes with rapid progression to mortality younger patients. So far, there no targeted treatment for TNBC. To end, here we show c-Abl one several tyrosine kinases phosphorylate and activate geminin's ability promote Analysis >800 tumor samples showed geminin overexpressed ∼50% tumors....
Human schistosomiasis is a freshwater snail-transmitted disease caused by parasitic flatworms of the Schistosoma genus. haematobium, mansoni, and japonicum are three major species infecting humans. These parasites undergo complex developmental life cycle, in which they encounter plethora environmental signals. The presence genes encoding universal stress protein (USP) domain genomes spp. suggests these equipped to respond unfavorable conditions. Though data on gene expression available for...
Obesity is a major global public health problem requiring multifaceted interventional approaches including dietary interventions with probiotic bacteria. High-throughput genome sequencing of microbial communities in the mammalian gastrointestinal system continues to present diverse protein function information understand bacterial determinants that influence obesity development. The goal research reported this article was identify biological processes bacteria could mechanisms for extraction...
Foodborne illnesses caused by microbial and chemical contaminants in food are a substantial health burden worldwide. In 2007, human vibriosis (non-cholera Vibrio infections) became notifiable disease the United States. addition, species among 31 major known pathogens transmitted through Diverse surveillance systems for foodborne also track outbreaks, illnesses, hospitalization deaths due to non-cholera vibrios. Considering recognition of as States availability diverse systems, there is need...
Arsenic is a widely distributed environmental toxicant that can cause multi-tissue pathologies. Proteomic assays allow for the identification of biological processes modulated by arsenic in diverse tissue types.
Improper localization of water channel proteins called aquaporins (AQP) induce mucosal injury which is implicated in Crohn’s disease and ulcerative colitis. The amino acid sequences AQP3 AQP10 are 79% similar belong to the mammalian aquaglyceroporin subfamily. localized on apical compartment intestinal epithelium glycocalyx while selectively targeted basolateral membrane. Despite high sequence similarity evolutionary relatedness, molecular mechanism involved polarity, selective targeting...
Arsenic is a ubiquitous environmental toxicant, and abnormalities of the skin are most common outcomes long-term, low-dose, chronic arsenic exposure. If balance between keratinocyte proliferation, differentiation, death perturbed, pathologic changes epidermis may result, including psoriasis, atopic dermatitis, certain forms ichthyosis. Therefore, research investigations using in vitro human epidermal cells could help elucidate cellular molecular processes keratinocytes affected by arsenic....
Exposure to inorganic arsenic induces skin cancer and abnormal pigmentation in susceptible humans. High-throughput gene transcription assays such as DNA microarrays allow for the identification of biological pathways affected by that lead initiation progression pigmentation. The overall purpose reported research was determine knowledge building insights on biomarker genes toxicity human epidermal cells integrating a collection lists annotated with information. information sets included...
Inorganic arsenic is a known environmental toxicant and carcinogen of global public health concern. Arsenic genotoxic cytotoxic to human keratinocytes. However, the biological pathways perturbed in keratinocytes by low chronic dose inorganic are not completely understood. The objective investigation was discover mechanism carcinogenicity epidermal We hypothesize that combined strategy DNA microarray, qRT-PCR gene function annotation will identify aberrantly expressed genes HaCaT keratinocyte...
The National Center for Integrative and Biomedical Informatics (NCIBI) is one of the eight NCBCs. NCIBI supports information access data analysis biomedical researchers, enabling them to build computational knowledge models biological systems address Driving Biological Problems (DBPs). DBPs have included prostate cancer progression, organ-specific complications type 1 2 diabetes, bipolar disorder, metabolic obesity syndrome. Collaborating with these other partners, has developed a series...