A5088383868- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Synthesis and properties of polymers
- Lung Cancer Treatments and Mutations
- Silicone and Siloxane Chemistry
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Intraocular Surgery and Lenses
- Melanoma and MAPK Pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Polymer Nanocomposites and Properties
- CAR-T cell therapy research
- Retinal Imaging and Analysis
- Cancer-related gene regulation
- Salivary Gland Tumors Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Cancer Genomics and Diagnostics
- Solid-state spectroscopy and crystallography
- Genital Health and Disease
- X-ray Diffraction in Crystallography
- Perovskite Materials and Applications
- Male Breast Health Studies
- Facial Trauma and Fracture Management
- Colorectal Cancer Treatments and Studies
- BRCA gene mutations in cancer
Nune Eye Hospital
2023-2024
Inje University Busan Paik Hospital
2013-2024
UC San Diego Health System
2023
Jeonju University
2021-2023
St. Vincent's Hospital
2019-2022
National Health Insurance Service Ilsan Hospital
2021
Catholic University of Korea
1993-2021
Seoul St. Mary's Hospital
2021
National Health Insurance Service
2021
Inje University Seoul Paik Hospital
2017-2018
Purpose ROS1 rearrangement is a distinct molecular subset of non–small-cell lung cancer (NSCLC). We investigated the efficacy and safety ceritinib in patients with ROS1-rearranged NSCLC. Patients Methods enrolled 32 advanced NSCLC who tested positive for by fluorescent situ hybridization. Ceritinib 750 mg was administered once daily. The primary end point objective response rate. secondary points were disease control rate; duration response; progression-free survival; overall toxicity;...
BACKGROUND Salivary gland cancers (SGCs) are uncommon and account for less than 5% of all head neck cancers, but they histologically heterogeneous. No specific therapy, including targeted agents, has consistently improved clinical outcomes in recurrent/metastatic SGC. Recent studies suggest that vascular endothelial growth factor receptor (VEGFR) platelet‐derived (PDGFR) play important roles Nintedanib is a potent small‐molecule, triple‐receptor tyrosine kinase inhibitor (VEGFR1, VEGFR2,...
Purpose To determine the characteristics of diabetic macular edema (DME) patients refractory to intravitreal bevacizumab (IVB) treatments and an additional dexamethasone implant. Methods We classified 119 DME according whether or not they are responsive 3 consecutive monthly anti-VEGF and/or compared their concentrations IL (interleukin)-1β, IL-8, IL-10, IL-17, placental growth factor (PlGF), vascular endothelial (VEGF) in aqueous humor as well optical coherence tomography (OCT) findings,...
Purpose. To investigate the relationship between macular thickness and axial length (AL) in myopic eyes. Methods. We included 441 eyes this study measured at fovea other regions, using optical coherence tomography. got difference indices (TDIs) which by definition are values of obtained subtracting foveal from that each macula sector to evaluate contour. then analyzed relationships AL TDIs sector. Results. In polynomial regression analyses, slope was relatively flat up an 25.5 mm began rise...
Imatinib mesylate is the first molecule of targeted therapy in chronic myelogenous leukaemia inhibiting constitutively activated BCR-ABL kinase. There are no long-term follow-up studies large sample sizes to assess toxicity use imatinib over 10 years. Several cases hepatotoxicity, including fatal liver failure, have been associated with mesylate. We report here on a patient who experienced immediate dominant cholestatic damage and mild hepatocyte during therapy. This differs from most...
The pyrimidine antimetabolite 5-fluorouracil (5-FU) is a chemotherapeutic agent used widely for various tumors. Common side effects of 5-FU are related to its on the bone marrow and gastrointestinal epithelium. Neurotoxicity caused by uncommon, although acute delayed forms have been reported. Wernicke's encephalopathy an acute, neuropsychiatric syndrome resulting from thiamine deficiency, has significant morbidity mortality. Central nervous system neurotoxicity such as following chemotherapy...
Abstract We designed this study to identify the epidemiological characteristics and trends of various types ocular trauma in population Republic Korea. conducted a nationwide, population-based, cross-sectional using Korean National Health Insurance claims database for January 2010 December 2018. compiled monthly numbers patients diagnosed with hyphema those who received open reduction surgery due orbital blowout fracture (BOF), primary closure cornea or sclera (PCCS), intraocular foreign...
Organic-inorganic hybrid perovskites have various potential applications in fuel cells and solar cells. In this regard, the physicochemical properties of an organic-inorganic [NH3(CH2)6NH3]CuCl4 crystal was conducted. The crystals had a monoclinic structure with space group P21/n lattice constants = 7.2224 Å, b 7.6112 c 23.3315 β 91.930°, Z 4 at 300 K, phase transition temperature (T C) determined to be 363 K by X-ray diffraction differential scanning calorimetry experiments. From nuclear...
Abstract Poly(amic acid) (PAA) is prepared by the reaction of dianhydride 4,4′-biphthalic anhydride and diamine bis[4-(3-aminophenoxy)phenyl]sulfone in N,N’ -dimethylacetamide. Two types fillers were dispersed as-synthesized PAA via a solution intercalation method; polyimide (PI) hybrid films synthesized under various heat treatment conditions. Octylamine (C8) was introduced into graphene sheets (C8-GS) bentonite (C8-BTN), which then used as nanofillers PI films. The varying amounts...
Single-site, single-system Langerhans cell histiocytosis (LCH) of the rib is one rarest causes bone tumor in adults. Herein, we report a case healthy 35-year-old male who presented with upper back pain that was attributed to solitary osteolytic lesion at posterolateral aspect his sixth rib. For diagnostic confirmation and treatment, partial resection performed pathologic finding consistent LCH. At final follow-up after 2 years, no local recurrence or metastasis observed.
The structures and phase transitions of [NH3(CH2)nNH3]MnCl4 (n = 2, 3, 4) crystals were confirmed through X-ray diffraction differential scanning calorimetry (DSC) experiments. Thermodynamic properties, ferroelastic molecular dynamics three studied as a function the number (n) CH2 groups in alkylene chains. loss weight due to decrease n marked onset partial thermal decomposition. decomposition temperature, Td, increased with increasing length chain. While twin domain walls for 2 4 same...
Poly(amic acid) (PAA) was synthesized from dianhydride 4,4-(4,4-isopropylidenediphenoxy)bis(phthalic anhydride) and diamine bis [4-(3-aminophenoxy) phenyl] sulfone. Colorless transparent polyimide (CPI) hybrid films were through thermal imidization after dispersing nanofillers using an intercalation method in a PAA solution. C16-GS C16-MMT, which hexadecylamine (C16) substituted on graphene sheet (GS) montmorillonite (MMT), respectively, used as to reinforce the CPI films. These two admixed...
Introduction: The ROR1-targeting antibody-drug conjugate zilovertamab vedotin (ZV) had a manageable safety profile and promising antitumor activity in patients (pts) with R/R NHL the phase 1 waveLINE-001 study (NCT03833180). We present updated results after 14 months of follow-up for pts diffuse large B-cell lymphoma (DLBCL), mantle cell (MCL), Richter transformation (RT). Methods: Eligible were ≥18 y; histologic diagnosis an ECOG PS 0–2. Pts must have disease progression during or relapse...
c-KIT mutations are found in approximately 15% of patients with malignant melanoma the Asian population. Regorafenib, an oral multikinase inhibitor, acts against both wild-type and mutant KIT.This multi-institutional, phase II, single-arm study aimed to evaluate efficacy regorafenib metastatic harbouring mutations.Patients positive for mutations, upon progression after at least one line systemic treatment, were enroled. Patients received 160 mg once daily 3 weeks (4-week cycle). The primary...
Purpose The optimal cytotoxic regimens have not been established for patients with non-small cell lung cancer (NSCLC) who develop disease progression on first-line epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). Materials and Methods We conducted a multi-center randomized phase II trial to compare the clinical outcomes between pemetrexed plus cisplatin combination therapy followed by maintenance (PC) monotherapy (P) after failure of EGFR-TKI. primary objective was...
The aims of this study were to investigate the correlation between topoisomerase II alpha (TOP2A), microtubule-associated protein-tau (MAP-tau) and other prognostic factors in breast cancer evaluate predictive value TOP2A MAP-tau patients who received anthracycline taxane-containing adjuvant chemotherapy.Seventy with axillary lymph node positive underwent curative surgery January 2000 December 2005 evaluated retrospectively. levels protein expression assessed using immunohistochemistry.Among...
Autophagy has been suggested to have an important role in the pathogenesis of Sjögren syndrome (SS). We previously identified that autophagy related 5 (ATG5) was elevated tear and conjunctival epithelial cells SS dry eyes (DE) compared non-SS DE. The purpose this study investigate ATG5 as a potential biomarker diagnosis SS. To confirm hypothesis, we evaluated concentration, other ocular tests (Schirmer I, breakup time (TBUT), surface staining (OSS) score, disease index (OSDI)) non-DE, their...
Abstract We designed a retrospective observational study to identify factors associated with ocular hypertension [OHTN, defined as intraocular pressure (IOP) > 25 mmHg] after intravitreal dexamethasone (IVD) implantation in diabetic macular edema (DME) patients. measured IOP monthly placement of an IVD implant, and identified the trend IOP, incidence OHTN, its systemic or factors. On average, was highest at 2 months implantation. Of 84 DME patients who received 3 (3.57%) presented ≥ mmHg...
6090 Background: Salivary gland cancers (SGC) are histologically uncommon but heterogeneous, accounting for less than 5% of all head and neck cancers. No specific therapy including targeted agents has been associated with improved clinical outcome in recurrent/metastatic SGC. Recent studies suggest VEGF PDGFR might play an important role Nintedanib is a potent small molecule triple receptor tyrosine kinase inhibitor (VEGFR1-3, FGFR 1-2, α/ß). We sought to determine nintedanib’s antitumor...
4,4′-(4,4′-isopropylidenediphenoxy)bis(phthalic anhydride) (BPADA) as a dianhydride and bis(3-aminophenyl) sulfone (APS) bis(3-amino-4-hydroxyphenyl) (APS-OH) diamines were used to synthesize two types of poly(amic acid) (PAA). Varying amounts (0–5.0 wt%) water-soluble poly(vinyl alcohol) (PVA) mixed with PAA, the resulting blend was heat-treated at different stages obtain colorless transparent polyimide (CPI) films. The synthesized blended film completely removed PVA in water. possibility...