A5051597820- Immune Cell Function and Interaction
- Endoplasmic Reticulum Stress and Disease
- Adenosine and Purinergic Signaling
- Psoriasis: Treatment and Pathogenesis
- T-cell and B-cell Immunology
- Heat shock proteins research
- CAR-T cell therapy research
- Vitamin D Research Studies
- Eosinophilic Esophagitis
- Immunotherapy and Immune Responses
- Diabetes and associated disorders
- Peptidase Inhibition and Analysis
- Reproductive System and Pregnancy
- Digestive system and related health
- Retinoids in leukemia and cellular processes
- Monoclonal and Polyclonal Antibodies Research
- Antioxidant Activity and Oxidative Stress
- COVID-19 Impact on Reproduction
- Organ and Tissue Transplantation Research
- Immune cells in cancer
- Systemic Lupus Erythematosus Research
University of Chile
2012-2023
Maintaining the identity of Foxp3 + regulatory T cells (Tregs) is critical for controlling immune responses in gut, where an imbalance between Tregs and effector has been linked to inflammatory bowel disease. Accumulating evidence suggests that can convert into Th17 acquire phenotype. In this study, we used adoptive transfer model Ag-specific study contribution different factors reprogramming vitro -generated Treg (iTreg) IL-17-producing a mouse gut inflammation vivo . Our results show...
T helper type 17 (Th17) lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, are present in intestinal lamina propria have been described as important players driving inflammation. Recent evidence, supporting notion a functional phenotypic instability Th17 cells, has shown that differentiate into 1 regulatory (Tr1) cells during resolution Moreover, it suggested expression CD39 ectonucleotidase endows with immunosuppressive properties. However,...
T helper type 17 (Th17) lymphocytes are found in high frequency tumour-burdened animals and cancer patients. These lymphocytes, characterized by the production of interleukin-17 other pro-inflammatory cytokines, have a well-defined role development inflammatory autoimmune pathologies; however, their function tumour immunity is less clear. We explored possible opposing anti-tumour tumour-promoting functions Th17 cells evaluating growth ability to promote infiltration myeloid-derived...
Summary The CD 73 ectonucleotidase catalyses the hydrolysis of AMP to adenosine, an immunosuppressive molecule. Recent evidence has demonstrated that this is up‐regulated in T helper type 17 cells when generated presence transforming growth factor‐ β ( TGF ‐ ), and hence expression related acquisition potential by these cells. also able induce 8 + but function still unknown. Here, we show Tc17 present high levels produce adenosine; however, they do not suppress proliferation 4 Interestingly,...
Memory CD8+ T cells are ideal candidates for cancer immunotherapy because they can mediate long-term protection against tumors. However, the therapeutic potential of different in vitro-generated cell effector subsets to persist and become memory has not been fully characterized. Type 1 (Tc1) produce interferon (IFN)-γ endowed with high cytotoxic capacity, whereas IL-17-producing (Tc17) less but display enhanced self-renewal capacity. We sought evaluate functional properties Tc17 elucidate...
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the activation of autoreactive T and B cells, autoantibody production, immune complex deposition in various organs. Previous evidence showed abnormal accumulation cells thymus lupus-prone mice, but role this population progression remains mostly undefined. Here we analyzed spatial distribution, function, properties thymic cell BWF1 murine model SLE. We found that diseased animals, proliferate cluster structures...
The initiation of adaptive immunity relies on the performance dendritic cells (DCs), which are specialized leukocytes with professional antigen presenting capabilities. As such, molecular mechanisms safeguarding DC homeostasis matter intense research. Sensors unfolded protein response (UPR) endoplasmic reticulum, a three-pronged signaling pathway that maintains fidelity cellular proteome, have emerged as regulators biology. archetypical example is IRE1/XBP1s axis, supports development and...
In cancer, activation of the IRE1/XBP1s axis unfolded protein response (UPR) promotes immunosuppression and tumor growth, by acting in cancer cells infiltrating immune cells. However, role dendritic (DCs) tumors, particularly conventional type 1 DCs (cDC1s) which are cellular targets immunotherapy, has not been fully elucidated. Here, we studied subcutaneous B16/B78 melanoma MC38 tumors generating loss-of-function models IRE1 and/or XBP1s or cDC1s. Data show that concomitant deletion RNase...
Several studies have demonstrated the contribution of innate immune cells, including macrophages, in promoting systemic lupus erythematosus (SLE). Macrophages, one most abundant cell populations peritoneal cavity, are considered multifunctional cells with phenotypic plasticity. However, functional properties macrophages steady-state and during progression SLE remain poorly defined.Using [NZB × NZW]F1 (BWF1) murine model SLE, we analyzed phenotype function disease's onset. We found a higher...
ABSTRACT The IRE1/XBPls axis of the unfolded protein response (UPR) plays divergent roles in dendritic cell (DC) biology steady state versus tumor contexts. Whereas associated DCs show dysfunctional IRE1/XBP1s activation that curtails their function, homeostasis conventional type 1 (cDC1) tissues requires intact IRE1 RNase activity. Considering cDC1s are key orchestrators antitumor immunity, it is relevant to understand functional DC subtypes. Here, we constitutively activate within...