A5077440911- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Adenosine and Purinergic Signaling
- Psoriasis: Treatment and Pathogenesis
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Histone Deacetylase Inhibitors Research
- Historical and socio-economic studies of Spain and related regions
- Immune Response and Inflammation
- Animal Genetics and Reproduction
- Eosinophilic Esophagitis
- Vitamin D Research Studies
- Sperm and Testicular Function
- Reproductive System and Pregnancy
- Epigenetics and DNA Methylation
- Antioxidant Activity and Oxidative Stress
- Reproductive Biology and Fertility
- Retinoids in leukemia and cellular processes
- Archaeological and Historical Studies
- Digestive system and related health
- Organ and Tissue Transplantation Research
- interferon and immune responses
- Phagocytosis and Immune Regulation
University of Chile
2012-2022
Consejo Nacional de Investigaciones Científicas y Técnicas
2010
National University of Mar del Plata
2010
As it has been established that demethylation of lysine 27 histone H3 by the lysine-specific demethylase JMJD3 increases immune responses and thus elicits inflammation, we hypothesize inhibition may attenuate autoimmune disorders. We found in vivo administration GSK-J4, a selective inhibitor UTX, ameliorates severity experimental encephalomyelitis (EAE). In vitro experiments revealed anti-inflammatory effect GSK-J4 was exerted through an on dendritic cells (DCs), promoting tolerogenic...
Maintaining the identity of Foxp3 + regulatory T cells (Tregs) is critical for controlling immune responses in gut, where an imbalance between Tregs and effector has been linked to inflammatory bowel disease. Accumulating evidence suggests that can convert into Th17 acquire phenotype. In this study, we used adoptive transfer model Ag-specific study contribution different factors reprogramming vitro -generated Treg (iTreg) IL-17-producing a mouse gut inflammation vivo . Our results show...
CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cells mediate immunological self-tolerance and suppress immune responses. Retinoic acid (RA), a natural metabolite of vitamin A, has been reported to enhance the differentiation Treg in presence TGF-β. In this study, we show that co-culture naive from C57BL/6 mice with allogeneic antigen-presenting (APCs) BALB/c TGF-β, RA, IL-2 resulted striking enrichment cells. These RA vitro-induced (RA-iTreg) did not secrete Th1-, Th2-, or Th17-related...
T helper type 17 (Th17) lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, are present in intestinal lamina propria have been described as important players driving inflammation. Recent evidence, supporting notion a functional phenotypic instability Th17 cells, has shown that differentiate into 1 regulatory (Tr1) cells during resolution Moreover, it suggested expression CD39 ectonucleotidase endows with immunosuppressive properties. However,...
T helper type 17 (Th17) lymphocytes are found in high frequency tumour-burdened animals and cancer patients. These lymphocytes, characterized by the production of interleukin-17 other pro-inflammatory cytokines, have a well-defined role development inflammatory autoimmune pathologies; however, their function tumour immunity is less clear. We explored possible opposing anti-tumour tumour-promoting functions Th17 cells evaluating growth ability to promote infiltration myeloid-derived...
Summary The CD 73 ectonucleotidase catalyses the hydrolysis of AMP to adenosine, an immunosuppressive molecule. Recent evidence has demonstrated that this is up‐regulated in T helper type 17 cells when generated presence transforming growth factor‐ β ( TGF ‐ ), and hence expression related acquisition potential by these cells. also able induce 8 + but function still unknown. Here, we show Tc17 present high levels produce adenosine; however, they do not suppress proliferation 4 Interestingly,...
Regulatory T cells are a specific subset of lymphocytes that suppress immune responses and play crucial role in the maintenance self-tolerance. They can be generated thymus as well periphery through differentiation naïve CD4 + cells. The forkhead box P3 transcription factor (Foxp3) is molecule regulating generation function Tregs. Here we show foxp3 gene promoter becomes hyperacetylated vitro differentiated Tregs compared to We also histone deacetylase inhibitor TSA stimulated into this...
Several studies have demonstrated the contribution of innate immune cells, including macrophages, in promoting systemic lupus erythematosus (SLE). Macrophages, one most abundant cell populations peritoneal cavity, are considered multifunctional cells with phenotypic plasticity. However, functional properties macrophages steady-state and during progression SLE remain poorly defined.Using [NZB × NZW]F1 (BWF1) murine model SLE, we analyzed phenotype function disease's onset. We found a higher...