A5089734294- Amino Acid Enzymes and Metabolism
- Cancer, Hypoxia, and Metabolism
- Metabolism and Genetic Disorders
- Cancer therapeutics and mechanisms
- Synthesis and biological activity
- Multiple and Secondary Primary Cancers
- Peroxisome Proliferator-Activated Receptors
- Organ Transplantation Techniques and Outcomes
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer Research and Treatments
- Synthesis and Biological Evaluation
- X-ray Diffraction in Crystallography
- Drug Transport and Resistance Mechanisms
- Metal complexes synthesis and properties
- Crystallization and Solubility Studies
- Cancer, Lipids, and Metabolism
- Sulfur Compounds in Biology
- Clinical Nutrition and Gastroenterology
- Nitric Oxide and Endothelin Effects
- Bioactive Compounds and Antitumor Agents
- Polyamine Metabolism and Applications
- Antibiotic Resistance in Bacteria
- Lung Cancer Diagnosis and Treatment
- Liver physiology and pathology
- Sphingolipid Metabolism and Signaling
Medical University of Warsaw
2016-2025
Ciprofloxacin (CP) has a confirmed cytotoxic action on some cancerous cells, but in high, non-pharmacological concentrations. Considering features of natural fatty acids, such as biocompatibility, biodegradability and their increased cellular uptake by cancer it seems that combining them with drug could improve its bioavailability, thus cytotoxicity. Therefore, the aim this study was coupling CP saturated unsaturated evaluation cytotoxicity, apoptosis-inducing effects inhibition IL-6 release...
Novel conjugates (CP) of moxifloxacin (MXF) with fatty acids (1m-16m) were synthesized good yields utilizing amides chemistry. They exhibit a more pronounced cytotoxic potential than the parent drug. most effective for prostate cancer cells an IC50 below 5 µM respective sorbic (2m), oleic (4m), 6-heptenoic (10m), linoleic (11m), caprylic (15m), and stearic (16m) acids. All derivatives evaluated against panel standard clinical bacterial strains, as well towards mycobacteria. The highest...
The present work is a continuation of studies on arginase as marker in the diagnosis colorectal cancer liver metastases (CRCLM). purpose study was evaluation test comparison with other tests such CEA, CA 19-9 and biochemical markers function aspartate aminotransferase (AST) alanine (ALT). were conducted blood serum from 85 patients CRCLM obtained one to two days before tumor resection. control group comprised 140 healthy donors 81 various non-malignant gastrointestinal diseases. Raised...
Aim: Linoleic acid (LA) and telmisartan as PPARgamma agonists exhibit anticancer activity. The LA effect is observed for high non-achievable in vivo concentrations short treatment period, therefore we evaluate the of supplemental pharmacological plasma on human primary (SW480) metastatic (SW620) colon cancer cells immortal keratinocytes (HaCaT) long-term treatment. Methods: Cell viability proliferation were determined by TB MTT pro-apoptotic was measured Annexin V binding assays,...
Substituted thiourea derivatives possess confirmed cytotoxic activity towards cancer but also normal cells. To develop new selective antitumor agents, a series of 3-(trifluoromethyl)phenylthiourea analogs were synthesized, and their cytotoxicity was evaluated in vitro against the cell line panel. Compounds 1-5, 8, 9 highly human colon (SW480, SW620) prostate (PC3) cells, leukemia K-562 lines (IC50 ≤ 10 µM), with favorable selectivity over HaCaT The exerted better growth inhibitory profiles...
To assess cytotoxic effect of ciprofloxacin conjugates with fatty acids on prostate cancer cells (LNCaP and DU-145) different hormone sensitivity, based previous promising results from the PC3 cells. Cytotoxicity were estimated using MTT LDH tests, whereas its mechanisms by apoptosis IL-6 assays. The intensity proteins involved in lipid metabolism was determined ML-CS assay. insensitive DU-145 more vulnerable than sensitive LNCaP IC50 values for oleic (4), elaidic (5) docosahexaenoic acid...
Cirrhosis leads to an inability of the liver perform its biochemical functions. It can also lead hepatocellular carcinoma in which, as we showed lately, arginase isoenzyme pattern changes. The present work presents our results on isoenzymes and their possible role cirrhosis. study was performed tissues obtained during transplantation from 60 patients with cirrhosis, samples histologically normal (control) 40 benign or colorectal cancer metastases removed surgery, 6-7 cm tumor border....
High glucose consumption and lactate synthesis in aerobic glycolysis are a hallmark of cancer cells. They can form also glutaminolysis, but it is not clear how oxygen availability affects this process. We studied at various levels human primary (SW480) metastatic (SW620) colon cells cultured with L-Ser and/or L-Asp. Glucose were determined colorimetrically, amino acids by HPLC, expression AST1-mRNA AST2-mRNA RT-PCR. In both lines higher 10% than 1% oxygen, lactate/glucose ratio was increased...
A series of eight copper (II) complexes with 3-(4-chloro-3-nitrophenyl)thiourea were designed and synthesized. The cytotoxic activity all compounds was assessed in three human cancer cell lines (SW480, SW620, PC3) normal keratinocytes (HaCaT). 1, 3, 5, 7 8 to the studied tumor cells low micromolar range, without affecting cells. induced lactate dehydrogenase (LDH) release lines, but not HaCaT They provoked early apoptosis pathological cells, especially SW480 PC3 ability diminish...