A5058118231- Synthesis and biological activity
- Free Radicals and Antioxidants
- Antimicrobial agents and applications
- Crystallization and Solubility Studies
- Cancer therapeutics and mechanisms
- biodegradable polymer synthesis and properties
- X-ray Diffraction in Crystallography
- Antibiotic Resistance in Bacteria
- Click Chemistry and Applications
- Antifungal resistance and susceptibility
- Synthesis and Biological Evaluation
- Biochemical and Structural Characterization
- Synthesis and Characterization of Heterocyclic Compounds
- Bee Products Chemical Analysis
- Bone Tissue Engineering Materials
- Bacterial biofilms and quorum sensing
- Antimicrobial Peptides and Activities
- Essential Oils and Antimicrobial Activity
- Bioactive Compounds and Antitumor Agents
- Redox biology and oxidative stress
- Healthcare and Venom Research
- Aluminum toxicity and tolerance in plants and animals
- Quinazolinone synthesis and applications
- Dye analysis and toxicity
- thermodynamics and calorimetric analyses
Medical University of Warsaw
2015-2024
Rzeszów University
2019-2022
Medical University of Silesia
2009
The adhesion and aggregation are characteristic attributes of probiotic strains belonging to Lactobacillaceae genus. Due these properties the host organisms can avoid colonisation intestinal tract by enteropathogenic bacteria. presented research includes a comparison various different species isolated from sources aim this study was investigate ability Lactocaseibacillus rhamnosus, Lactiplantibacillus plantarum, Lactobacillus (L. acidophilus, L. gasseri, ultunensis) products clinical...
Ciprofloxacin (CP) has a confirmed cytotoxic action on some cancerous cells, but in high, non-pharmacological concentrations. Considering features of natural fatty acids, such as biocompatibility, biodegradability and their increased cellular uptake by cancer it seems that combining them with drug could improve its bioavailability, thus cytotoxicity. Therefore, the aim this study was coupling CP saturated unsaturated evaluation cytotoxicity, apoptosis-inducing effects inhibition IL-6 release...
Rape honey with the addition of Aronia melanocarpa dried fruits is a new product, enriched additional bioactive compounds, increased antioxidant potential and enhanced antibacterial antiviral activity.
A novel series of N-acylated ciprofloxacin (CP) conjugates 1-21 were synthesized and screened as potential antimicrobial agents. Conjugates 1 2 1.25-10-fold more potent than CP toward all Staphylococci (minimal inhibitory concentration 0.05-0.4 μg/mL). Most the chloro- (3-7), bromo- (8-11), CF3-alkanoyl (14-16) derivatives expressed higher or comparable activity to against selected Gram-positive strains. few analogues (5, 10, 11) also effective chosen clinical Gram-negative rods. 5, 11...
Curcumin is a biologically active compound of vegetable origin which has hormetic effect. Pro-health and anti-aging properties curcumin have been known for years. The main benefit thought to be its anti-oxidative action. Despite vast amount data confirming age-delaying activity in various groups organisms, so far little discovered about curcumin's impact on cell aging the experimental model Saccharomyces cerevisiae budding yeast. We able demonstrate that significantly increases oxidative...
Abstract Shiga toxin-producing Escherichia coli (STEC) are zoonotic pathogens causing hemorrhagic colitis and hemolytic uremic syndrome (HUS) in children the elderly. Stool samples were collected from 180 hospitalized five pediatric centers Poland 2018–2022. Direct stx1 / stx2 gene detection by PCR feces E. isolates was performed. Antibiotic susceptibility tested according to EUCAST v.12. Randomly selected serotyped with O157 antiserum genotyped pulsed-field gel electrophoresis (PFGE). A...
Free living, cosmopolitan amoebae from Acanthamoeba genus present a serious risk to human health. As facultative parasites, these may cause keratitis (AK). is severe, vision-threatening corneal infection with non-specific symptoms. The number of reported AK cases worldwide has been increasing every year. Moreover, 90% are related contact lens use. Wearing and storage lenses not in accordance the physicians manufacturers recommendations primary key factors this disease. Amoebae can easily...
A series of novel 4-chloro-3-nitrophenylthiourea derivatives were synthesized and evaluated for their antimicrobial, antibiofilm tuberculostatic activities. Most compounds exhibited high antibacterial activity against both standard hospital strains (MIC values 0.5-2 μg/mL), as compared to Ciprofloxacin. Derivatives with 3,4-dichlorophenyl (11) 3-chloro-4-methylphenyl (13) substituents the most promising towards Gram-positive pathogens. Both them potency effectively inhibited formation...
The aim of the study was to use protein and polyphenolic profiles as fingerprints goldenrod honey apply them for verification labeled variety. markers 10 samples were correlated with standard physicochemical parameters biological activity measured in vitro antioxidant, antifungal antibacterial activities. Honey proteins examined regarding soluble protein, diastase SDS-PAGE profile. profile obtained HPTLC antioxidant detected colorimetric methods. antimicrobial effect representative different...
Novel biodegradable and biocompatible formulations of "old" but "gold" drugs such as nystatin (Nys) amphotericin B (AmB) were made using a biopolymer matrix. Medium chain length polyhydroxyalkanoates (mcl-PHA) used to formulate both polyenes (Nys AmB) in the form films (~50 µm). Thermal properties stability materials not significantly altered by incorporation mcl-PHA, polyene containing more hydrophobic. These tested vitro against panel pathogenic fungi for antibiofilm properties. The 0.1 2...
Sugar esters are bioactive compounds derived from renewable resources. They consist of a sugar moiety with attached non-polar part – usually fatty acid. These find uses in cosmetic, food and pharmaceutical industries as surfactants due to their physicochemical antimicrobial activities. In this study we have produced acids for ester synthesis bacterially polyesters, namely polyhydroxyalkanoates (PHAs). We developed methodology decorate PHA monomers fluorinated moiety. With aid biocatalysis...
Staphylococcus spp. are Gram-positive bacteria that can be opportunistic pathogens capable of causing life-threatening infections. aureus, the most harmful species among them produces heat-resistant endotoxins, which cause food intoxications. Staphylococci may form biofilms on food-processing surfaces and become more resistant to routinely used antimicrobials. The bacteriolytic enzymes Auresine AuresinePlus, both derived from S. aureus LytM autolysin engineered catalytic domain, were tested...
A set of 21 thiourea derivatives were prepared through reacting 3-amino-1H-1,2,4-triazole with the commercial aliphatic and aromatic isothiocyanates. The isothiocyanate was used as reagent leading to substitution on NH atom 3-aminotriazole ring, whereas triazole amino group substituted when bonded Csp2 hybridized atom, e.g. an aryl or C=O fragment. All compounds evaluated in vitro for antimicrobial activity. 1, 2, 4, 8, 9, 10 12 showed highest inhibition against Gram-positive cocci (S....
Staphylococcus epidermidis, a coagulase-negative Staphylococcus, is the most important pathogen responsible for chronic nosocomial infections. These bacteria produce extracellular slime and form biofilms on various biotic abiotic surfaces. Bacterial are very resistant to standard antimicrobial therapy difficult eradicate, so it search new more effective anti-biofilm agents, example in group of natural substances. The aim study was examine activity two ionophores-salinomycin monensin against...
Thirty new derivatives of palmitic acid were efficiently synthesized. All obtained compounds can be divided into three groups derivatives: Thiosemicarbazides (compounds 1–10), 1,2,4-triazoles 1a–10a) and 1,3,4-thiadiazoles 1b–10b) moieties. 1H-NMR, 13C-NMR MS methods used to confirm the structure derivatives. tested in vitro against a number microorganisms, including Gram-positive cocci, Gram-negative rods Candida albicans. Compounds 4, 5, 6, 8 showed significant inhibition C. The range MIC...