A5011950552- Extracellular vesicles in disease
- Synthesis and biological activity
- Atherosclerosis and Cardiovascular Diseases
- MicroRNA in disease regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- CAR-T cell therapy research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Immune Cell Function and Interaction
- Computational Drug Discovery Methods
- Drug Transport and Resistance Mechanisms
- Biochemical Acid Research Studies
- Advanced Glycation End Products research
- Virus-based gene therapy research
- Obstructive Sleep Apnea Research
- Nitric Oxide and Endothelin Effects
- Cancer therapeutics and mechanisms
- RNA Interference and Gene Delivery
- Neuroscience of respiration and sleep
- Immune Response and Inflammation
- Synthesis of Tetrazole Derivatives
- Click Chemistry and Applications
- Melanoma and MAPK Pathways
- Crystallography and molecular interactions
- Nanoplatforms for cancer theranostics
Medical University of Warsaw
2016-2025
Glioblastoma is the most common malignant primary brain tumor in adult population, with an average survival of 12.1 to 14.6 months. The standard treatment, combining surgery, radiotherapy, and chemotherapy, not as efficient we would like. However, current possibilities are no longer limited therapies due rapid advancements biotechnology. New methods enable a more precise approach by targeting individual cells antigens overcome cancer. For treatment glioblastoma, these gamma knife therapy,...
Ciprofloxacin (CP) has a confirmed cytotoxic action on some cancerous cells, but in high, non-pharmacological concentrations. Considering features of natural fatty acids, such as biocompatibility, biodegradability and their increased cellular uptake by cancer it seems that combining them with drug could improve its bioavailability, thus cytotoxicity. Therefore, the aim this study was coupling CP saturated unsaturated evaluation cytotoxicity, apoptosis-inducing effects inhibition IL-6 release...
Mycophenolate mofetil (MMF) has beneficial effects in cardiac transplant patients beyond the suppression of tissue rejection. Moreover, mycophenolic acid (MPA), its active metabolite, been associated with positive on atherosclerosis animal models. The attachment leukocytes to vascular endothelium and subsequent migration these cells into vessel wall are early events inflammation atherosclerosis. aim this study was investigate MPA tumour necrosis-α (TNF-α)-induced, endothelial cell...
Enhanced DNA damage and disturbances in repair mechanisms are reported to be involved the pathogenesis of chronic diseases like obesity, atherosclerosis, metabolic syndrome, diabetes, cancer. The aim present study was evaluate whether anthropometric factors dietary habits related endogenous damage. One hundred fourteen premenopausal, apparently healthy women were included study: 88 obese individuals 26 controls. comet assay used measure basal Biochemical measurements lipids,...
Atherosclerosis is a chronic inflammatory disease driven by lipid accumulation in the arteries, leading to narrowing and thrombosis that causes mortality. Emerging evidence has confirmed atherosclerosis affects younger people involved majority of deaths worldwide. EVs are associated with critical steps atherosclerosis, cholesterol metabolism, immune response, endothelial dysfunction, vascular inflammation, remodeling. Endothelial cell-derived can interact platelets monocytes, thereby...
Reactive oxygen species (ROS) play a key role in the pathogenesis of atherosclerosis. The main mechanisms which are involved low-density lipoprotein oxidative modification, inactivation nitric oxide and modulation redox-sensitive signaling pathways. ROS contribute to several aspects atherosclerosis including endothelial cell dysfunction, monocyte/macrophage recruitment activation, stimulation inflammation, inducing smooth muscle migration proliferation. NADPH oxidase is source vasculature....
To assess cytotoxic effect of ciprofloxacin conjugates with fatty acids on prostate cancer cells (LNCaP and DU-145) different hormone sensitivity, based previous promising results from the PC3 cells. Cytotoxicity were estimated using MTT LDH tests, whereas its mechanisms by apoptosis IL-6 assays. The intensity proteins involved in lipid metabolism was determined ML-CS assay. insensitive DU-145 more vulnerable than sensitive LNCaP IC50 values for oleic (4), elaidic (5) docosahexaenoic acid...
The current diet and lifestyle are commonly known contributing factors of atherosclerosis, which is the underlying disorder in patients with cardiovascular disease. An identification any kinds foods that may exert cardioprotective or cardiotoxic influence deeper understanding their molecular mechanisms action has become an object interest due to importance. Through largely epidemiological evidence, trans fatty acids (TFAs) intake been associated a variety complications, including...
CAR-T cell therapy has revolutionized the treatment of hematological malignancies with high remission rates in case ALL and NHL. This some limitations such as long manufacturing periods, persistent restricted sources costs. Moreover, combination regimens increase risk immune-related adverse events, so identification new therapeutic targets is important to minimize toxicities guide more effective approaches. Cancer cells employ several mechanisms evade immunosurveillance, which causes...