A5022500462- Oral Health Pathology and Treatment
- Oral and Maxillofacial Pathology
- Advanced Glycation End Products research
- Oral microbiology and periodontitis research
- Oral and gingival health research
- Dental Education, Practice, Research
- Virus-based gene therapy research
- Genetic factors in colorectal cancer
- Orthodontics and Dentofacial Orthopedics
- Autoimmune Bullous Skin Diseases
- Herpesvirus Infections and Treatments
- Head and Neck Cancer Studies
- Obesity and Health Practices
- Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
University of Helsinki
2023-2024
City of Helsinki
2019
Herttoniemi Hospital
2019
Lichen planus (LP) is a T-cell-mediated inflammatory disease affecting squamous epithelia in many parts of the body, most often skin and oral mucosa. Cutaneous LP usually transient (OLP) chronic, so we performed large-scale genetic epidemiological study to address whether non-oral subgroups have shared or distinct underlying pathologies their overlap with autoimmune disease. Using lifelong records covering diagnoses, procedures, clinic identity from 473,580 individuals FinnGen study,...
Introduction: Oral tongue squamous cell carcinoma (OTSCC) is the most common cancer of oral cavity. Contradictory results have been observed on involvement herpes simplex virus 1 (HSV-1) in carcinomas. Here, we aimed to study predominance HSV-1 or HSV-2 HSV infections and investigate presence OTSCC its effect viability invasion. Methods: The distribution types one two diagnostic samples taken from suspected was determined Helsinki University Hospital Laboratory database. We then analysed 67...
High mobility group box 1 ( HMGB 1) is an extremely conserved DNA ‐binding protein that stabilizes nucleosomes and facilitates gene transcription in mammalian cells. When released extracellularly, becomes alarmin can mediate systemic diseases. signals via two main receptors: receptor for advanced glycation end‐products RAGE ) toll‐like receptor‐4 TLR 4). We hypothesized expression increased patients with oral lichen planus OLP relative to healthy controls. Therefore, its receptors were...
Objective: An association between hypothyroidism (HT) and oral lichen planus (OLP) has been reported. However, the mechanisms that could explain this remain unresolved. This study aimed to evaluate expression of thyroid-stimulating hormone (TSH) receptor (TSHR) in healthy mucosa OLP lesions individuals with without HT.Material methods: Immunohistochemical TSH TSHR was studied mucosal biopsies obtained from 14 patients HT, HT 10 controls lesions. Gene investigated by using three different PCR...