A5027098088- Nutrition and Health in Aging
- Hip and Femur Fractures
- Cerebral Palsy and Movement Disorders
- Adipose Tissue and Metabolism
- Musculoskeletal pain and rehabilitation
- Peroxisome Proliferator-Activated Receptors
- Balance, Gait, and Falls Prevention
- Frailty in Older Adults
- Obstructive Sleep Apnea Research
- Osteoarthritis Treatment and Mechanisms
- Cardiovascular and exercise physiology
- Metabolism, Diabetes, and Cancer
- Neuroscience of respiration and sleep
- Body Composition Measurement Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Physical Activity and Health
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Emergency and Acute Care Studies
- Muscle metabolism and nutrition
- Cancer-related molecular mechanisms research
- Lower Extremity Biomechanics and Pathologies
- Diet and metabolism studies
- Pharmacology and Obesity Treatment
- Asthma and respiratory diseases
- Healthcare Decision-Making and Restraints
University of Maryland, Baltimore
2014-2025
Geriatric Research Education and Clinical Center
2014-2025
VA Maryland Health Care System
2019-2025
University of Baltimore
2022-2023
Baltimore VA Medical Center
2013-2022
University of South Florida
2014-2015
Johns Hopkins University
2000-2010
National Institute on Aging
2010
National Institutes of Health
2010
Columbia University
2010
Peroxisome proliferator activated receptor-gamma (PPARγ) is a nuclear receptor that regulates adipocyte differentiation, and possibly lipid metabolism insulin sensitivity. As such, PPARγ promising candidate gene for several human disorders including obesity type 2 diabetes mellitus. Screening mutations in the entire coding region of (both γ1 γ2 isoforms) was performed with DNA 26 diabetic Caucasians or without obesity. Two base substitutions were identified: silent mutation at nucleotide...
Activation of peroxisome proliferator-activated receptor-gamma by thiazolidinediones (TZDs) results in lower bone mass mice.The objective the study was to determine whether TZD use is associated with changes mineral density (BMD) older adults type 2 diabetes.We analyzed 4-yr follow-up data from Health, Aging, and Body Composition observational study.The conducted a general community.White black, physically able men women, aged 70-79 yr at baseline diabetes defined self-report, hypoglycemic...
It is well established that sleep-disordered breathing (SDB) independently associated with insulin resistance, glucose intolerance, and type 2 diabetes mellitus. However, data on whether SDB alters in vivo kinetics of are lacking.The primary goal this study was to use the frequently sampled intravenous tolerance test (FSIVGTT) subjects without model insulin. Minimal analysis FSIVGTT used derive parameters sensitivity, effectiveness (a measure ability mediate its own disposal), pancreatic...
Individual measurements of inflammation have been utilized to assess adverse outcomes risk in older adults with varying degrees success. This study was designed identify biologically informed, aggregate measures for optimal assessment and inform further biological inflammatory pathways. In total, 15 nuclear factor-kappa B-mediated pathway markers were first measured baseline serum samples 1,155 participants the InCHIANTI population. Of these, C-reactive protein, interleukin-1-receptor...
The nuclear receptor, peroxisome proliferatora c t ivated receptor( P PA R ), is an important regulator of adipocyte differentiation and a modulator intracellular insulin-signaling events (1). PPA mRNA expression in both skeletal muscle adipose tissue vitro induced by insulin (2,3). In obese subjects, elevated direct relation to BMI fasting insulinemia (2); reports are mixed as whether increased subjects (3–5). one report, activators were shown increase adiposity rodent model (6), while...
It is well established that medical conditions such as obesity and cardiovascular disease are associated with increased levels of inflammatory biomarkers C-reactive protein (CRP). Prior studies have produced inconsistent results regarding the association between sleep disordered breathing (SDB) CRP, possibly due to confounding effects or comorbidity. The present study examined degree SDB level CRP independent prevalent obesity. Cross-sectional study. University-based clinical sample referred...
OBJECTIVES: To assess the relationship between rate of change in muscle strength and all‐cause mortality. DESIGN: Prospective observational study causes course physical disability. SETTING: Twelve contiguous ZIP code areas Baltimore, Maryland. PARTICIPANTS: Three hundred seven community‐dwelling women aged 70 to 79 at baseline. MEASUREMENTS: The outcome was mortality (1994–2009); predictors included up repeated measurements handgrip, knee extension, hip flexion strength, with a median...
Impaired balance, loss of mobility and falls are major problems associated with changes in muscle older adults. However, the extent to which composition related performance measures for different lower limb muscles individuals is unclear. This study evaluated attenuation, intramuscular adipose tissue (IMAT) infiltration fallers non-fallers. For this cross-sectional study, fifty-eight community dwelling (>65 years) were classified into (n = 15) or non-fallers 43). Computed tomography (CT) was...
<h3>Importance</h3> Disability persists after hip fracture in older persons. Current rehabilitation may not be sufficient to restore ability walk the community. <h3>Objective</h3> To compare a multicomponent home-based physical therapy intervention (training) with an active control on <h3>Design, Setting, and Participants</h3> Parallel, 2-group randomized clinical trial conducted at 3 US centers (Arcadia University, University of Connecticut Health Center, Maryland, Baltimore). Randomization...
Neopterin, a GTP metabolite expressed by macrophages, is marker of immune activation. We hypothesize that levels this serum alter with donor age, reflecting increased chronic activation in normal aging. In addition to we assessed gender, race, body mass index (BMI), and percentage fat (%fat) as potential covariates. Serum was obtained from 426 healthy participants whose age ranged 18 87 years. Anthropometric measures included %fat BMI. Neopterin concentrations were measured competitive...
Background Mitochondria contribute to the dynamics of cellular metabolism, production reactive oxygen species, and apoptotic pathways. Consequently, mitochondrial function has been hypothesized influence functional decline vulnerability disease in later life. Mitochondrial genetic variation may altered susceptibility frailty syndrome older adults. Methodology/Principal Findings To assess potential contributions likelihood frailty, DNA (mtDNA) was compared frail non-frail Associations...
Objective Differences in cognitive outcomes for two home-based 16-week interventions after usual rehabilitative care post-hip fracture were examined. Methods Community Ambulation Project randomized controlled trial included 210 hip participants. Interventions: Specific multi-component (PUSH) strength-, balance-, function-, and endurance-based exercises; non-specific active control (PULSE) seated range-of-motion exercises sensory transcutaneous electrical neurostimulation. Cognitive measures:...
<sec> <title>BACKGROUND</title> Foot ulcers are a common complication of diabetes, often resulting from peripheral neuropathy and inadvertent trauma. Poor healing is exacerbated by arterial disease poor glycemic control. Off-loading, key treatment, leads to prolonged immobility. Patients rarely regain baseline mobility. Mobility crucial improve glycemia, promote vascular health immobility as it nursing home admissions. There limited research on exercise during ulcer remission. </sec>...
Depressive symptoms are common in patients with knee osteoarthritis (KOA) and reduce energy, motivation, movement; thus, declines physical activity (PA) could worsen as clinical disease progresses. The objective was to evaluate the longitudinal relationship between depressive self-reported PA over time among persons KOA. sample included Osteoarthritis Initiative participants (N = 2602) radiographic (Kellgren-Lawrence grade ≥ 2). were measured using Center for Epidemiologic Studies Depression...
Abstract Background The COVID-19 pandemic has had a profound impact on older adults, particularly those with existing comorbidities. To inform targeted healthcare strategies for this heterogeneous group, study seeks to analyze and compare mortality trends among various geriatric age groups within the Veterans Affairs (VA) Health Care System, both during era pre-COVID era, while accounting demographic clinical factors such as age, gender, race, Methods A retrospective cohort using Informatics...
OBJECTIVE—Previous studies have reported modest associations between measures of obesity and the Trp64Arg variant β3-adrenergic receptor (ADRβ3) Pro12Ala peroxisome proliferator–activated (PPAR)-γ2. We hypothesized that these single gene variants may mark mutations act through convergent pathways to produce synergistic effects on obesity. RESEARCH DESIGN AND METHODS—The sample included 453 subjects from 10 large Mexican-American families participating in population-based San Antonio Family...
Peroxisome proliferator-activated receptor gamma (PPARgamma)-2 is a member of the nuclear hormone superfamily that expressed predominantly in adipocytes and thought to have role energy homeostasis, adipogenesis, insulin sensitivity. A functional single nucleotide polymorphism (SNP) predicts proline alanine substitution (Pro12Ala) within coding region this gene has previously been associated with obesity type 2 diabetes several populations. In study, we identified novel SNPs promoter...
We determined the chromosomal localization and partial genomic structure of coding region human PPARγ gene (hPPARγ), a nuclear receptor important for adipocyte differentiation function. Sequence analysis long PCR DNA with primers that span putative introns revealed intron positions sizes hPPARγ are similar to those previously mouse gene[13]. Fluorescent in situ hybridization localized chromosome 3, band 3p25. Radiation hybrid mapping two independent primer pairs was consistent being within...
The physical manifestations of aging reflect a loss homeostasis that effects molecular, cellular and organ system functional capacity. As sentinel homeostatic pathway, changes in apoptosis can have pathophysiological consequences both disease. To assess baseline global balance, sera from 204 clinically normal subjects had levels sFas (inhibitor apoptosis), sFasL (stimulator total cytochrome c (released cells during apoptosis) measured. Serum were significantly higher while lower men compared...
Background: Intramuscular adipose tissue (IMAT) of the lower extremity is a strong negative predictor mobility function. Variability in temporal gait factors another important The purpose this study was to examine relationships between IMAT hip and thigh muscles, balance, variability older adults. Methods: Forty-eight healthy community dwelling adults (74 +/- 1 year) underwent CT scan quantify gluteus maximus (Gmax), medius/minimus (Gmed/min), hamstrings, vastus lateralis, adductor muscles....