A5068191798- Balance, Gait, and Falls Prevention
- Cerebral Palsy and Movement Disorders
- Musculoskeletal pain and rehabilitation
- Motor Control and Adaptation
- Adipose Tissue and Metabolism
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Stroke Rehabilitation and Recovery
- Tactile and Sensory Interactions
- Parkinson's Disease Mechanisms and Treatments
- Genetics, Aging, and Longevity in Model Organisms
- Nutrition and Health in Aging
- Neurological disorders and treatments
- Children's Physical and Motor Development
- Effects of Vibration on Health
- Geriatric Care and Nursing Homes
- Cardiovascular and exercise physiology
- Vestibular and auditory disorders
- Lower Extremity Biomechanics and Pathologies
- Advanced Neuroimaging Techniques and Applications
- Grief, Bereavement, and Mental Health
- Hearing Loss and Rehabilitation
- Psychology of Development and Education
- Palliative Care and End-of-Life Issues
- Optical Imaging and Spectroscopy Techniques
- Botulinum Toxin and Related Neurological Disorders
Saint Joseph's University
2022
National Institute on Aging
2017-2021
University of the Sciences
2020-2021
National Institutes of Health
2018
University of Maryland, Baltimore
2011-2017
University of Maryland, College Park
2007-2011
Taipei Veterans General Hospital
1996
Aging is associated with distinct phenotypical, physiological, and functional changes, leading to disease death. The progression of aging-related traits varies widely among individuals, influenced by their environment, lifestyle, genetics. In this study, we conducted physiologic tests cross-sectionally throughout the entire lifespan male C57BL/6N mice. parallel, metabolomics analyses in serum, brain, liver, heart, skeletal muscle were also performed identify signatures frailty age-dependent...
Impaired balance, loss of mobility and falls are major problems associated with changes in muscle older adults. However, the extent to which composition related performance measures for different lower limb muscles individuals is unclear. This study evaluated attenuation, intramuscular adipose tissue (IMAT) infiltration fallers non-fallers. For this cross-sectional study, fifty-eight community dwelling (>65 years) were classified into (n = 15) or non-fallers 43). Computed tomography (CT) was...
Background: Intramuscular adipose tissue (IMAT) of the lower extremity is a strong negative predictor mobility function. Variability in temporal gait factors another important The purpose this study was to examine relationships between IMAT hip and thigh muscles, balance, variability older adults. Methods: Forty-eight healthy community dwelling adults (74 +/- 1 year) underwent CT scan quantify gluteus maximus (Gmax), medius/minimus (Gmed/min), hamstrings, vastus lateralis, adductor muscles....
Background Developmental Coordination Disorder (DCD) is a leading movement disorder in children that commonly involves poor postural control. Multisensory integration deficit, especially the inability to adaptively reweight changing sensory conditions, has been proposed as possible mechanism but with insufficient characterization. Empirical quantification of reweighting significantly advances our understanding its developmental onset and improves characterization difference DCD compared...
Abstract In the last two decades, great strides were made in our ability to extend life span of model organisms through dietary and other manipulations. Survival curves provide evidence altered aging processes but are uninformative on what lead that increase span. Longitudinal assessments health function during intervention studies could help identification predictive biomarkers for survival. Comparable healthspan necessary effectively translate interventions into human clinical trials. Gait...
Severe muscular spasticity encountered frequently in patients with spastic cerebral palsy not only affects patient locomotor function but also causes musculoskeletal complications. Significant reduction of over pelvis and lower limbs after selective posterior rhizotomy (SPR) results improvement trunk stability, function, upper also. The purpose this study was to investigate the difference sitting balance before SPR using a quantitative measurement stability represented as dispersion index...
Abstract Background The Pittsburgh Fatigability Scale (PFS) was developed to capture fatigue and demand in a single tool, filling gap that no validated questionnaire existed measure perceived fatigability. Since fatigability is more sensitive of person’s susceptibility fatigue, we the simplified-Chinese version PFS among Chinese community-dwelling older adults. Methods This cross-sectional study conducted an urban community Beijing between November 2018 July 2019. translated into by...
Age-related brain changes affect timing and coordination of gait as well cognition. Gait variability is strongly associated with cognitive function, particularly executive but longitudinal studies associations between baseline subsequent declines are rare. A sample 141 older participants from the Baltimore Longitudinal Study Aging (mean age=75.9 ± 7.2; female 32.6%) underwent assessment including temporal (double support time, swing stance cycle step time) spatial (step width, stride length)...
While innumerable indicators of age-related gait change exist, almost none integrate or summarize segmental coordination during movement. Planar Covariation Elevation Angles (PCEA) was developed to study changes development, but may help characterize changes. PCEA reflects among leg segment angles relative vertical (thigh, shank and foot), resulting in a loop that lie plane rotate with increasing walking speed. We assessed features Baltimore Longitudinal Study Aging adults without diagnoses...