A5033978207- Sulfur-Based Synthesis Techniques
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Organoselenium and organotellurium chemistry
- Fluorine in Organic Chemistry
- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Neonatal Health and Biochemistry
- Cyclopropane Reaction Mechanisms
- Synthesis of Organic Compounds
- Carbon dioxide utilization in catalysis
- Catalytic Cross-Coupling Reactions
- Multicomponent Synthesis of Heterocycles
- Click Chemistry and Applications
- Chemical Synthesis and Reactions
- Asymmetric Hydrogenation and Catalysis
- Biochemical and Molecular Research
- Chemical Reactions and Isotopes
- Chemical Synthesis and Analysis
- Organic Chemistry Cycloaddition Reactions
- Synthesis of heterocyclic compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactivity of Heterocycles
- Carbohydrate Chemistry and Synthesis
Sardar Patel University
2021-2025
Abstract The development of an efficient alternative to the widely employed Balz‐Schiemann deaminative fluorination method (i. e. without using aryl diazonium tetrafluoroborate salt) is a challenging task. Herein, we report convenient one‐pot for FeCl 3 ‐nanocellullose mediated mechanochemical synthesis fluoroarenes through selective substitution aromatic amino group by fluorine pyrylium (Pyry‐BF 4 ) and sodium fluoride (NaF) via in situ formation pyridinium salt intermediate. scope present...
Abstract A convenient route for the mechanochemical synthesis of fluorinated aromatic compounds, that is, fluoro, trifluoromethyl, and trifluoromethoxy arenes, has been developed via pyrylium tetrafluoroborate (Pyry‐BF 4 )‐mediated desulfonamidative cross‐coupling primary sulfonamides under synergy a piezoelectric material BaTiO 3 , Ru‐catalysis. This is first‐ever report on selective transformation sulfonamide (SO 2 NH ) functionality to CF /OCF /F group in single step ball‐milling...
Herein, we report the first mechanochemical strategy for Ru-catalyzed deoxygenative borylation of free phenols via C–O bond cleavage. This phenolic approach has been successfully extended to Suzuki–Miyaura-type cross-coupling with aryl bromides. The protocol accepts a wide scope substrates, allowing synthesis pinacolboranes and biphenyl structures in excellent yields serving as better alternative classical reactions context pot, atom, step economy synthesis.
A novel strategy has been introduced for the selective activation of N–C(O) moiety in primary aromatic amides through utilization pyrylium tetrafluoroborate under mechanochemical conditions, where amide group...
Abstract A facile synthetic protocol has been established for the N ‐chlorosuccinimide (NCS) promoted direct C−H thiocyanation of 1‐aryl‐5‐pyrazolones via in situ‐ generated electrophilic thiocyanating agent at room temperature. The current features easy performance, mild conditions and short reaction time using readily available starting materials. DFT studies suggested that ionic process is likely to be involved this transformation yielding targeted product with most stable enaminone form...
Abstract A facile synthetic strategy has been established for the microwave‐assisted construction of two C−C bond via regioselective double arylation imidazo[1,2‐ a ]pyridines with 1,2‐diiodobenzene by employing Pd(OAc) 2 as catalyst. The current protocol exhibited simple, efficient and ligands free synthesis 1‐phenylbenzo[ ]imidazo[5,1,2‐ cd ]indolizine derivatives in good to excellent yields. This Pd‐catalyzed dual provided valuable tool discovery fluorescent materials.
The construction of C-S bond is considered as an important protocol in organic transformations. An innovative strategy for CuI-catalyzed sulfenylation 1-aryl-3-alkyl-1H-pyrazol-5(4H)-ones have been developed using elemental sulfur the source. This procedure provides a useful and direct approach assembly wide range structurally diverse 4-sulfenyl pyrazolones with moderate to excellent yields from simple readily available starting materials. method might be potentially applicable large scale...
Abstract In this contribution, we provide a comprehensive overview on the C−H activation/functionalization reactions of 1‐aryl‐5‐pyrazolones, in particular, 1‐aryl‐3‐methyl‐1H‐pyrazol‐5(4H)‐ones (edaravones) and their N ‐methyl analogues i. e ., antipyrines covering literature since 2013 (the year first report). This review summarizes recent progress functionalization 1‐aryl‐5‐pyrazolones including edaravone antipyrine derivatives under transition‐metal‐catalyzed/free conditions discusses...
Abstract A simple and efficient strategy for N‐chlorosuccinimide mediated regioselective C−H sulfenylation halogenation of 4 H ‐pyrido[1,2‐ a ]pyrimidin‐4‐ones has been established at room temperature using aryl thiols phenyliodine(III) diacetate (PIDA) respectively. This methodology tolerated broad variety functional groups to obtain structurally diverse sulfenyl halogenated ‐pyrido[1,2‐a]pyrimidin‐4‐one derivatives under mild conditions. It delivered range products which can serve as the...