A5088865807- Ion Channels and Receptors
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Gastrointestinal motility and disorders
- Magnesium in Health and Disease
- Magnetic and Electromagnetic Effects
- Bone Metabolism and Diseases
- Gastroesophageal reflux and treatments
- NF-κB Signaling Pathways
- Neuropeptides and Animal Physiology
- Genetic Neurodegenerative Diseases
- Bone health and treatments
- thermodynamics and calorimetric analyses
- Genetic and Kidney Cyst Diseases
- Helicobacter pylori-related gastroenterology studies
Chosun University
2019-2024
Seoul National University
2021-2024
New Generation University College
2021
Seoul National University Hospital
2021
National University College
2021
G-protein coupled receptors (GPCRs) and ion channels serve as key molecular switches through which extracellular stimuli are transformed into intracellular effects, it has long been postulated that direct effector molecules of the alpha subunit G-proteins (Gα). However, no complete structural evidence supporting interaction between Gα is available. Here, we present cryo-electron microscopy structures human transient receptor potential canonical 5 (TRPC5)-Gα
GPCR-G i protein pathways are involved in the regulation of vagus muscarinic pathway under physiological conditions and closely associated with internal visceral organs. The receptor-operated cationic channel is important signal transduction as it decreases heart rate increases GI rhythm frequency. In SA node heart, acetylcholine binds to M2 receptor released Gβγ activates GIRK (I(K,ACh)) channel, inducing a negative chronotropic action. gastric smooth muscle, there two (mAChR) subtypes, M3....
Abstract Background The discovery of receptor activator nuclear factor‐ĸB ligand (RANKL) as the final effector in pathogenesis osteoporosis has led to a better understanding bone remodeling. When RANKL binds its (RANK), osteoclastic differentiation and activation are initiated. Herein, we propose strategy using novel variant competitive inhibitor for RANKL. activates LGR4 signaling, which competitively regulates RANK acts an immunogen that induces anti‐RANKL antibody production. Methods We...
Endogenous opioid systems modulate pain perception, but concerns about opioid-related substance misuse limit their use. This study has raised TRPC4 channel as a candidate target for alternative analgesics, tricyclic antidepressants (TCAs). TCAs have been shown to bind and activate receptors (ORs), leading downstream signaling pathways involving TRPC4. The functional selectivity biased agonism of TCA towards in dependence on OR may provide better understanding its efficacy or side effects.
Abstract Tricyclic antidepressants (TCAs) have been used to treat depression and were recently approved for treating irritable bowel syndrome (IBS) patients with severe or refractory IBS symptoms. However, the molecular mechanism of TCA action in gastrointestinal (GI) tract remains poorly understood. Transient receptor potential channel canonical type 4 (TRPC4), which is a Ca 2+ ‐permeable nonselective cation channel, critical regulator GI excitability. Herein, we investigated whether...
Prokinetic agents are effective in increasing gastrointestinal (GI) contractility and alleviating constipation, often caused by slow intestinal motility. Lubiprostone (LUB), known for activating CLC-2 chloride channels, increases the ion concentration GI tract, supporting water retention stool movement. Despite its therapeutic efficacy, exact mechanisms underlying pharmacological action poorly understood. Here, we investigated whether LUB activates canonical transient receptor potential...
PKD1 regulates a number of cellular processes through the formation complexes with PKD2 ion channel or transient receptor potential classical (TRPC) 4 in endothelial cells. Although Ca
Abstract Background: Tricyclic antidepressants (TCAs) have been used to treat depression and were recently approved for treating irritable bowel syndrome (IBS) patients with severe or refractory IBS symptoms. However, the molecular mechanism of TCA action in gastrointestinal (GI) tract remains poorly understood. Transient receptor potential channel canonical type 4 (TRPC4), which is a Ca 2+ -permeable nonselective cation channel, critical regulator GI excitability. Herein, we investigated...