A5072590089- Ion Channels and Receptors
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Postharvest Quality and Shelf Life Management
- thermodynamics and calorimetric analyses
- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Receptor Mechanisms and Signaling
- Magnetic and Electromagnetic Effects
- Cystic Fibrosis Research Advances
- Cardiac electrophysiology and arrhythmias
- Plant Stress Responses and Tolerance
- Protist diversity and phylogeny
- Genetic and Kidney Cyst Diseases
- Neurobiology and Insect Physiology Research
National Institutes of Health
2024
National Eye Institute
2024
University of California, San Francisco
2023-2024
Seoul National University
2020-2024
GPCR-G i protein pathways are involved in the regulation of vagus muscarinic pathway under physiological conditions and closely associated with internal visceral organs. The receptor-operated cationic channel is important signal transduction as it decreases heart rate increases GI rhythm frequency. In SA node heart, acetylcholine binds to M2 receptor released Gβγ activates GIRK (I(K,ACh)) channel, inducing a negative chronotropic action. gastric smooth muscle, there two (mAChR) subtypes, M3....
Transient receptor potential channels canonical 1 and 4 (TRPC1 TRPC4) are proteins belonging to the same TRPC channel family, two known form a heterotetrameric channel. TRPC4 can homotetrameric, nonselective cation by itself, but involvement of TRPC1 subunit changes several major characteristics In this study, we focused on pore region (selectivity filter, helix, S6 helix) as determinant identity heteromeric TRPC1/4 channel: decreased calcium permeability outward-rectifying current-voltage...
Photoreceptors in the mammalian retina convert light signals into electrical and molecular through phototransduction transfer visual inputs to second-order neurons via specialized ribbon synapses. Two kinds of photoreceptors, rods cones, possess distinct morphology function. Currently, we have limited knowledge about rod versus (vs.) cone synapse development associated genes. The transcription factor neural leucine zipper (NRL) determines vs. photoreceptor cell fate is critical for differentiation.
KCNQ family constitutes slowly-activating potassium channels among voltage-gated channel superfamily. Recent studies suggested that KCNQ4 and 5 are abundantly expressed in smooth muscle cells, especially lower urinary tract including corpus cavernosum both can exert membrane stabilizing effect the tissues. In this article, we examined electrophysiological characteristics of overexpressed KCNQ4, HEK293 cells with recently developed KCNQ-specific agonist. With submicromolar EC50, drug not only...
Autosomal dominant polycystic kidney disease (ADPKD) is the leading monogenic cause of failure and affects millions people worldwide. Despite prevalence this disorder, our limited mechanistic understanding ADPKD has hindered therapeutic development. Here, we successfully developed bioassays that functionally classify missense variants in polycystin-1 (PC1). Strikingly, pathogenic cluster into two major categories: 1) those disrupt polycystin cell surface localization or 2) attenuate ion...
Transient Receptor Potential Canonical (TRPC) channels constitute calcium‐permeable, non‐selective cation in mammalian cells. The expression of TRPC4 can be found gastrointestinal (GI) tract, endometrium, ventricular myocytes, vascular smooth muscle cells, endothelium and many others. In such tissues, it is well‐known that exert membrane excitatory effect due to inwardly‐rectifying nature current‐voltage (I‐V) relationship the channels. Based on electrophysiological similarity between...