A5110249342- Neurofibromatosis and Schwannoma Cases
- Multiple Myeloma Research and Treatments
- Urological Disorders and Treatments
- Ureteral procedures and complications
- Pancreatic function and diabetes
- Sarcoma Diagnosis and Treatment
- Diabetes and associated disorders
- Urinary Bladder and Prostate Research
- Glioma Diagnosis and Treatment
- Pediatric Urology and Nephrology Studies
- Kidney Stones and Urolithiasis Treatments
- Diabetes Management and Research
- Prostate Cancer Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- Ovarian cancer diagnosis and treatment
- Neuroblastoma Research and Treatments
- Peripheral Nerve Disorders
- Reproductive Biology and Fertility
- Endometrial and Cervical Cancer Treatments
- Acute Myeloid Leukemia Research
- Leaf Properties and Growth Measurement
- Advanced Glycation End Products research
- Genomic variations and chromosomal abnormalities
- Smart Agriculture and AI
- Single-cell and spatial transcriptomics
Bio-Medical Science (South Korea)
2024
University of California, San Francisco
2008-2023
Bharati Vidyapeeth Deemed University
2018-2023
Deenanath Mangeshkar Hospital and Research Center
2010-2017
Washington University in St. Louis
2008-2011
University Health Network
2011
Mayo Clinic
2009-2011
University of Nebraska Medical Center
2011
Cleveland Clinic
2011
King's College London
2011
Cytogenetic analysis of acute myeloid leukemia (AML) cells has accelerated the identification genes important for AML pathogenesis. To complement cytogenetic studies and to identify altered in genomes, we performed genome-wide copy number with paired normal tumor DNA obtained from 86 adult patients de novo using 1.85 million feature SNP arrays. Acquired alterations (CNAs) were confirmed an ultra-dense array comparative genomic hybridization platform. A total 201 somatic CNAs found genomes...
<b>Objective:</b> Independent studies have previously demonstrated that both the <i>HIPK2</i> and <i>BRAF</i> genes are amplified rearranged, respectively, in pilocytic astrocytomas (PAs). The purpose of this study was to further investigate frequency alterations PAs, concordance these events, their relationship clinical phenotype. <b>Methods:</b> We performed extensive characterization by array-based copy number assessment (aCGH), analysis, rearrangement mutation analysis a set 79 including...
Malignant peripheral nerve sheath tumors (MPNST) are highly aggressive sarcomas with variable patient survival and few known prognostically relevant genomic biomarkers. To identify survival-associated biomarkers, we performed high-resolution array-based comparative hybridization (aCGH) on a large set of MPNSTs.Candidate gene alterations identified by aCGH in 38 MPNSTs were validated at the DNA, RNA, protein levels these same an independent 87 MPNST specimens.aCGH revealed complex copy number...
Different fusion oncogenes in acute myeloid leukemia (AML) have distinct clinical and laboratory features suggesting different modes of malignant transformation. Here we compare the vitro effects representatives 4 major groups AML on primary human CD34+ cells. As expected from their similarities, MLL-AF9 NUP98-HOXA9 had very similar vitro. They both caused erythroid hyperplasia a clear block maturation. On other hand, AML1-ETO PML-RARA only modest differentiation. All except dramatic...
Abstract Background Pilocytic Astrocytomas (PAs) are common low-grade central nervous system malignancies for which few recurrent and specific genetic alterations have been identified. In an effort to better understand the molecular biology underlying pathogenesis of these pediatric brain tumors, we performed higher-order transcriptional network analysis a large gene expression dataset identify regulatory pathways that this tumor type, relative other, more aggressive glial or histologically...
Microarrays depend on appropriate probe design to deliver the promise of accurate genome-wide measurement. Probe design, ideally, produces a unique probe-target match with homogeneous duplex stability over complete set probes. Much microarray pre-processing is concerned adjusting for non-ideal probes that do not report target concentration accurately. Cross-hybridizing (non-unique), composition and structure, as well platform effects such instrument limitations, have been shown affect...
Background: This study was conducted to explore the impact of various factors like estrogen levels on day HCG trigger, type IVF cycle, dose gonadotropin along with patient characteristics age and BMI number M2 oocytes retrieved. Materials And Methods: Data from Indore Infertility Clinic October 2023 December utilized. Statistical analyses were performed using MedCalc version 22 (MedCalc Software Ltd, 2024). Results: It noted that mean count lower for those E2 levels, although result could...
Objectives: The objective is to compare monopolar transurethral resection of the prostate (M-TURP) versus bipolar TURP (B-TURP). Methods: In this prospective comparative study, 102 patients scheduled undergo were enrolled and table randomized surgery by M-TURP or B-TURP. International Prostate Symptom Score (IPSS), uroflowmetry, ultrasonography (kidney-ureter-bladder), prevoid, postvoid laboratory investigations (for preanesthetic fitness) done preoperative 3-month postsurgery. Results:...
This case report discusses a 23-year-old male with recurrent priapism and its management. Priapism, defined as prolonged painful penile erection, can lead to severe complications including permanent erectile dysfunction (ED) deformities. The patient presented lasting 34 hours, despite previous spontaneous resolution of similar episodes. Initial treatment involved blood aspiration irrigation epinephrine, but the recurred. Various shunting procedures were attempted, yet persisted. Discussion...
Purpose: HoLEP is now considered gold standard for the treatment of BPH allowing one stop surgical all sizes glands. The Bipolar TURP carries some advantages like use normal saline which allows resection longer period time. Additionally, there less learning curve bipolar TURP. We have conducted a prospective and retrospective observational study to compare evaluate with respect efficacy outcomes in our tertiary care hospital. Materials methods: done retrospective, comparative from June 2012...
Urinary tract infection (UTI) is a common in patients with type 2 diabetes (T2DM). We present case series of recurrent and complicated UTI requiring hospitalization people T2DM. Recurrence UTI, especially when severe or complicated, causes multiple renal extra complications even death if not intervened early. Recurrent often caused by resistant pathogens long duration uncontrolled glucose levels. In complicated/severe empirical broad-spectrum antimicrobial therapy early urological...
Carcinoma of prostate rarely metastasizes to the testis. It is most common primary cancers among all solid malignancies contributing majority testicular metastases. Here, we report such type rare case in a 64-year-old man who presented with history severe lower urinary tract symptoms and progressively increasing swelling right The was subsequently diagnosed as cancer metastasis.
<p>Supplementary Materials and Methods; Supplementary Tables S1-S5.</p>
<div>Abstract<p><b>Purpose:</b> Malignant peripheral nerve sheath tumors (MPNST) are highly aggressive sarcomas with variable patient survival and few known prognostically relevant genomic biomarkers. To identify survival-associated biomarkers, we performed high-resolution array-based comparative hybridization (aCGH) on a large set of MPNSTs.</p><p><b>Experimental Design:</b> Candidate gene alterations identified by aCGH in 38 MPNSTs were...
<div>Abstract<p><b>Purpose:</b> Malignant peripheral nerve sheath tumors (MPNST) are highly aggressive sarcomas with variable patient survival and few known prognostically relevant genomic biomarkers. To identify survival-associated biomarkers, we performed high-resolution array-based comparative hybridization (aCGH) on a large set of MPNSTs.</p><p><b>Experimental Design:</b> Candidate gene alterations identified by aCGH in 38 MPNSTs were...
<p>Supplementary Materials and Methods; Supplementary Tables S1-S5.</p>
Introduction - Since their inception in 1967, Double J (DJ) stents have been widely used for the purpose of alleviation extrinsic and intrinsic obstruction. They are as a modality maintaining patency well drainage urinary tract to facilitate passage small fragments post intervention. However, delayed removal or failure follow up may lead complications form stent encrustation, migration, fracture, stone formation, adjacent organ penetration, infections (UTI), ureteral erosion, fistula...