A5034256226- Cellular transport and secretion
- Heat Transfer and Optimization
- Heat Transfer and Boiling Studies
- RNA regulation and disease
- RNA Research and Splicing
- Protein Kinase Regulation and GTPase Signaling
- Fluid Dynamics and Heat Transfer
- Ubiquitin and proteasome pathways
- Endoplasmic Reticulum Stress and Disease
- Cell Adhesion Molecules Research
- Calcium signaling and nucleotide metabolism
- Cellular Mechanics and Interactions
- Spacecraft and Cryogenic Technologies
- Microtubule and mitosis dynamics
- Erythrocyte Function and Pathophysiology
- Retinal Development and Disorders
Innsbruck Medical University
2024-2025
Universität Innsbruck
2024-2025
Robert Bosch (Germany)
2023
University of Stuttgart
2018-2022
Protein kinase D3 (PKD3) is an important regulator of triple-negative breast cancer (TNBC) progression by promoting invasion, proliferation, and stem cell maintenance. However, the mechanism underlying these cellular functions has remained unclear. Here, we report that endogenous PKD3 localizes to Rab7/Lamp1-positive vesicles in MDA-MB-231 cells cultured on stiff matrices. Notably, upon depletion size Rab7-positive smaller. This correlates with impaired endosomal acidification, which...
Cancer cells degrade the extracellular matrix through actin-rich protrusions termed invadopodia. The formation of functional invadopodia requires polarized membrane trafficking driven by Rho GTPase-mediated cytoskeletal remodeling. We identify GTPase-activating protein deleted in liver cancer 3 (DLC3; also known as STARD8) an integral component endosomal transport and sorting machinery. provide evidence for direct regulation RhoB DLC3 at membranes to which is recruited interacting with nexin...
Abstract The Rho GTPase activating protein Deleted in Liver Cancer 1 (DLC1) is frequently downregulated through genetic and epigenetic mechanisms various malignancies, leading to aberrant signaling thus facilitating cancer progression. Here we show that breast cells, dysregulation of DLC1 expression occurs at the level rapid degradation via ubiquitin–proteasome system. Using mass spectrometry, identify two novel interaction partners, ubiquitin-ligase HECTD1 deubiquitinating enzyme...
Many newly synthesized cellular proteins pass through the Golgi complex from where secretory transport carriers sort them to plasma membrane and extracellular environment. The formation of these at trans-Golgi network is promoted by protein kinase D (PKD) family serine/threonine kinases. Here, using mathematical modeling experimental validation PKD activation substrate phosphorylation kinetics, we reveal that expression level deleted in liver cancer 1 (DLC1), a Rho GTPase-activating...
Three transparent experimental setups of flat-plate pulsating heat pipes vertical orientation were investigated, each with a different channel surface roughness in the evaporator section. Roughness was varied using milling and sand blasting techniques. Experiments conducted refrigerant R1233zd(E) filling ratios 30%, 50% 70%. Heat flux values between 5 45 W condenser temperatures 0°C, 20°C 40°C applied. Low ratios, high found to achieve lowest thermal resistances. Increased section also...