A5035919299- Dental Health and Care Utilization
- Oral microbiology and periodontitis research
- Health disparities and outcomes
- Dental Anxiety and Anesthesia Techniques
- Thyroid Disorders and Treatments
- Mitochondrial Function and Pathology
- Pediatric health and respiratory diseases
- Cystic Fibrosis Research Advances
- Pituitary Gland Disorders and Treatments
- Dental Research and COVID-19
- Smoking Behavior and Cessation
- Metabolism and Genetic Disorders
- Thyroid Cancer Diagnosis and Treatment
- Obesity and Health Practices
- Adolescent and Pediatric Healthcare
- Transplantation: Methods and Outcomes
- Head and Neck Cancer Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bipolar Disorder and Treatment
- Employment and Welfare Studies
- Complement system in diseases
- Tourism, Volunteerism, and Development
- Global Education and Multiculturalism
- Oral health in cancer treatment
- Temporomandibular Joint Disorders
Newcastle University
2013-2024
University of Newcastle Australia
2015
Freeman Hospital
2009-2010
Chapel Allerton Hospital
2010
Diana Princess of Wales Hospital
2010
Royal Hallamshire Hospital
2010
Objective. To determine whether low-dose ciclosporin was a more effective corticosteroid-sparing agent than AZA in patients with SLE.
Cough is a common, disabling symptom of idiopathic pulmonary fibrosis (IPF), which may be exacerbated by acid reflux. Inhibiting gastric secretion could potentially reduce cough. This study aimed to determine the feasibility larger, multicentre trial omeprazole for cough in IPF, assess safety and quantify cough.Single-centre, double-blind, randomised, placebo-controlled pilot proton pump inhibitor (PPI) (20 mg twice daily 3 months) patients with IPF. Primary objectives were acceptability...
This multicenter 3-arm, parallel-group, patient-randomized controlled trial compared clinical effectiveness of 3 treatment strategies over y for managing dental caries in primary teeth UK care. Participants aged to 7 with at least 1 molar dentinal carious lesion were randomized across arms (1:1:1 via centrally administered system variable-length random permuted blocks): C+P, conventional management (complete tooth tissue removal and restoration placement) prevention; B+P, biological (sealing...
Objectives To determine the accuracy of area based Townsend Deprivation Scores (TDSs) as proxies for individual level deprivation and to compare ability TDSs measures predict selfreported health.
Tobacco smoking is a major risk factor for several oral diseases, including periodontitis, and electronic cigarettes (e-cigarettes) are increasingly being used cessation. This study aimed to assess the viability of delivering evaluating an e-cigarette intervention cessation within dental setting, prior definitive study.A feasibility study, comprising pilot randomised controlled trial qualitative process evaluation, was conducted over 22 months in Newcastle upon Tyne Hospitals NHS Dental...
Background Historically, lack of evidence for effective management decay in primary teeth has caused uncertainty, but there is emerging to support alternative strategies conventional fillings, which are minimally invasive and prevention orientated. Objectives The objectives were (1) assess the clinical effectiveness cost-effectiveness three managing caries (2) quality life, dental anxiety, acceptability experiences children, parents professionals, development and/or progression. Design This...
Background Consumption of fruit and vegetables is important for health, but often lower than recommended tends to be socio-economically patterned with consumption in more deprived groups. In 2008, the English Department Health introduced Change4Life convenience store programme. This aimed increase retail access fresh deprived, urban areas by providing existing stores a range support branded point-of-sale materials equipment. Methods We undertook mixed-methods study programme North East...
Oral mucositis is a debilitating and painful complication of head neck cancer irradiation that characterised by inflammation the mucous membranes, erythema ulceration. affects 6000 patients per year in England Wales. Current treatments have not proven to be effective. International studies suggest low-level laser therapy may an effective treatment. To assess clinical effectiveness cost-effectiveness management oral irradiation. identify barriers facilitators implementing routine care....
Lifestyle interventions can prevent type 2 diabetes (T2D) in adults with impaired glucose tolerance. In a mixed methods pilot study, we aimed to assess the feasibility, acceptability and outcomes at 12-month follow-up of behavioural intervention for risk T2D.Adults aged 45-65 years Finnish Diabetes Risk Score (FINDRISC) ≥11.The was delivered leisure community settings local authority that ranks 10 most socioeconomically deprived England.A 10-week supported programme promote increased...
Hypothyroidism is a common condition, particularly in the older population. Thyroid hormone requirements change with age and serum TSH levels also alter, especially patients. However, practice laboratory reference ranges for thyroid function are not age-specific treatment patients aims to achieve similar target level as younger groups. A dual centre, single blind, randomised controlled trial was conducted determine feasibility of future definitive RCT hypothyroid individuals aged 80 years or...
Abstract Background The population of the UK is ageing. There compelling evidence that thyroid stimulating hormone distribution levels increase with age. Currently, in clinical practice elderly hypothyroid patients are treated levothyroxine to lower their a standard non-age-related range. Evidence suggests mortality negatively associated levels. We report protocol feasibility study working towards full-scale randomized controlled trial test whether dose has beneficial cardiovascular outcomes...
Abstract Background A three-arm parallel group, randomised controlled trial set in general dental practices England, Scotland, and Wales was undertaken to evaluate three strategies manage caries primary teeth. Children, with at least one molar into dentine, were receive Conventional best practice prevention (C + P), Biological (B or Prevention Alone (PA). Methods Data on costs collected via case report forms completed by clinical staff every visit. The co-primary outcomes incidence of,...
Abstract Objectives The FiCTION trial compared co‐primary outcomes (dental pain and/or infection) and secondary (child oral health‐related quality of life [COHRQOL], child dental anxiety, cost‐effectiveness, caries development/progression acceptability) across three treatment strategies (Conventional with Prevention [C + P]; Biological [B Alone [PA]) for managing in children primary care. COHRQOL anxiety experiences are reported upon here. Methods A multi‐centre, 3‐arm, parallel‐group,...
There has been comparatively little patient information about bronchiectasis, a chronic lung disease with rising prevalence. Patients want more information, which could improve their understanding and self-management. A novel resource meeting identified needs co-developed in prior work. We sought to establish the feasibility of conducting multi-centre randomised controlled trial determine effect on understanding, self-management health outcomes.We conducted an unblinded, single-centre, two...
There is substantial evidence from high income countries that neighbourhoods have an influence on health independent of individual characteristics. However, neighbourhood characteristics are rarely taken into account in the analysis urban studies developing countries. Informal home to about half population Aleppo, second largest city Syria (population>2.5 million). This study aimed examine socioeconomic status (SES) and formality self-rated (SRH) adult men women residing formal informal...
Introduction: Serum thyroid-stimulating hormone (TSH) increases with age but target TSH is similar in younger and older hypothyroid patients on treatment. It unknown if quality of life (QoL), symptoms cardiovascular risk factors change treated to an age-appropriate reference range. Objective: To assess a higher serum 4.01–8.0 mU/L feasible in, acceptable to, patients. Methods: A single-blind (participant) randomised controlled feasibility trial involving 48 aged ≥80 years established stable...
The purpose of this paper is to examine the prevalence alcohol use disorders (AUDs) amongst young people in criminal justice system (CJS) North East England and compare ability Alcohol Use Disorders Identification Test (AUDIT) Youth Justice Board ASSET tool identifying alcohol-related need Offending Team (YOT) clients.A validated screening was used identify health risk or harm. Findings from AUDIT were compared with those standard criminogenic CJS (ASSET). An anonymous cross-sectional...
Abstract Background Mitochondrial disease is a heterogenous group of rare, complex neurometabolic disorders. Despite their individual rarity, collectively mitochondrial diseases represent the most common cause inherited metabolic disorders in UK; they affect 1 every 4300 individuals, up to 15,000 adults (and similar number children) UK. manifests multisystem and isolated organ involvement, commonly affecting those tissues with high energy demands, such as skeletal muscle. Myopathy...
Background . To assess and correlate orthodontic treatment characteristics outcomes in an educational setting. Methods A total of 287 patients were included. Independent chart reviews conducted to gather demographic pretreatment diagnostic information. Posttreatment digital records graded with the ABO C-R Eval CCA methods. Pearson correlation coefficients calculated determine associations between variables. Results Of patients, 122 (42.5%) male 165 (57.5%) female. The average time was 33.87...
The management of carious primary teeth is a challenge for patients, parents and clinicians. Most evidence supporting different strategies originates from specialist setting therefore its relevance to the care questionable. UK National Institute Health Research (NIHR) Technology Assessment (HTA) has commissioned FiCTION (Filling Children's Teeth: Indicated Or Not?) trial; multi-centre dental randomised controlled trial (RCT) determine most clinically cost-effective approach managing caries...
The aim of this study is to examine the feasibility a future definitive randomised controlled trial Family Focused Treatment for Adolescents UK (FFT-A UK) in management early-onset bipolar disorder (EOBD) (under 18 years). FFT-A has been evaluated USA augment pharmacological treatment adolescents with (BD). condensed 16 sessions over approximately 6 months be utilised within National Health Service. Research from suggests that families experience high levels distress, stress, burden and...
Abstract Background Smoking continues to be the single largest cause of preventable disease and death a major contributor health inequalities. Dental professionals are well placed offer behavioural support in combination with pharmacotherapy increase smoking cessation rates across population. We aimed assess trends socioeconomic inequalities dental attendance adult smokers Scotland from 2009 2019 examine potential population reach settings for interventions. Methods A secondary analysis was...
This first mixed-methods UK trial examined the feasibility and acceptability of a future definitive randomised controlled (RCT) to evaluate whether Family Focussed Treatment for Adolescents with Bipolar Disorder (FFT-A) version can improve family functioning well-being as part management Paediatric (PBD). The used randomised, parallel group, non-blinded design where participants received FFT-A (16 sessions over 6 months) immediately or after 12 months (delayed arm). Measures functioning,...