A5101476101- Xenotransplantation and immune response
- Clinical Nutrition and Gastroenterology
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Infant Nutrition and Health
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Liver physiology and pathology
- Antimicrobial Peptides and Activities
- Organ and Tissue Transplantation Research
- Immunotherapy and Immune Responses
- Biomedical Ethics and Regulation
- Wnt/β-catenin signaling in development and cancer
- Cancer Immunotherapy and Biomarkers
Columbia University
2023-2024
City of Hope
2024
Introduction Thymokidneys (TK) have been constructed to transplant life-supporting kidney grafts containing donor thymic tissue induce tolerance. Historically, TKs were by inserting pieces of thymus under the capsule using an intra-abdominal or posterior retroperitoneal (lateral/flank) approach. The approach is technically easier but causes adhesions and makes procurement more challenging. fewer complications, implantation demanding due limited visibility exposure kidney. We herein describe...
Background Despite advances in immunosuppressive therapies, chronic rejection and immunosuppression-related complications remain significant challenges transplantation. Developing transplantation tolerance through thymus may offer a solution. This paper details our technique for procuring transplanting porcine vascularized thymic lobes (VTL), which can be utilized to study research allogeneic xenogeneic models large animals. Methods GalT-KO miniature swine ( n = 16) baboons 12) were used VTL...