A5065007746- Health disparities and outcomes
- Genetics, Aging, and Longevity in Model Organisms
- Global Health Care Issues
- Frailty in Older Adults
- Insurance, Mortality, Demography, Risk Management
- Birth, Development, and Health
- Nutrition and Health in Aging
- Genetic Associations and Epidemiology
- Aging and Gerontology Research
- Health Systems, Economic Evaluations, Quality of Life
- Nutritional Studies and Diet
- Diet and metabolism studies
- Intensive Care Unit Cognitive Disorders
- Mitochondrial Function and Pathology
- Menopause: Health Impacts and Treatments
- Telomeres, Telomerase, and Senescence
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Alzheimer's disease research and treatments
- Advanced Statistical Methods and Models
- Adipokines, Inflammation, and Metabolic Diseases
- Estrogen and related hormone effects
- Neonatal Respiratory Health Research
- Dementia and Cognitive Impairment Research
- Testicular diseases and treatments
University of Southern Denmark
2016-2025
Danish Pain Research Center
2021
University of Copenhagen
2013-2020
Odense University Hospital
2017-2020
Rigshospitalet
2020
Aarhus University
2013
To determine whether perceived age correlates with survival and important related phenotypes.Follow-up study, of twins determined up to January 2008, by which time 675 (37%) had died.Population based twin cohort in Denmark.20 nurses, 10 young men, 11 older women (assessors); 1826 aged >or=70.Assessors: from photographs. Twins: physical cognitive tests molecular biomarker ageing (leucocyte telomere length).For all three groups assessors, was significantly associated survival, even after...
Telomerase is of key importance for telomere maintenance, and variants the genes encoding its major subunits, telomerase reverse transcriptase (TERT) RNA component (TERC), are candidates interindividual variation in length. Recently, two SNPs rs3772190 rs12696304 TERC locus were reported to be associated with leukocyte length (LTL) genome-wide association studies, while one haplotype TERT (rs2853669, rs2736098, rs33954691, rs2853691) has been both LTL longevity a candidate gene study. In...
Aging | doi:10.18632/aging.101216. Troels Steenstrup, Jeremy D. Kark, Simon Verhulst, Mikael Thinggaard, Jacob V. B. Hjelmborg, Christine Dalgård, Kirsten Ohm Kyvik, Lene Christiansen, Massimo Mangino, Timothy Spector, Inge Petersen, Masayuki Kimura, Athanase Benetos, Carlos Labat, Ronit Sinnreich, Shih-Jen Hwang, Daniel Levy, Steven C. Hunt, Annette L. Fitzpatrick, Wei Chen, Gerald S. Berenson, Michelangela Barbieri, Giuseppe Paolisso, Shahinaz M. Gadalla, Sharon A. Savage, Kaare...
In the call for papers (Alley DE, Ferrucci L, Barbagallo M, Studenski SA, Harris TB. A research agenda: changing relationship between body weight and health in aging. J Gerontol Biol Sci Med Sci. 2008;63(11):1257–1259.), it is assumed that association mass index (BMI [kilogram per square meter]) mortality becomes increasingly U-shaped with advancing age. The aim of this study to examine BMI test whether age persons aged 70–95 years Denmark. populations comprised two surveys: Longitudinal...
Background.Leukocyte telomere length (LTL) ostensibly shortens with age and has been moderately associated mortality. In humans, these findings have come almost solely from cross-sectional studies. Only recently LTL shortening within individuals analyzed in longitudinal Such studies are relevant to establish dynamics as biomarkers of mortality well disentangle the causality telomeres on aging.
Adult mortality has been postponed over time to increasingly high ages. However, evidence on past and current health trends mixed, little is known about European disability trends.In a cross-sectional setting, we compared cognitive physical functioning in same-aged Europeans aged 50+ between 2004-05 (wave 1; n = 18 757) 2013 5 refresher respondents; 16 696), sourced from the Survey of Health, Ageing Retirement Europe (SHARE).People had better function with persons 2004-05, an average...
Objectives To determine whether simple functional indicators are predictors of survival prognosis in very old adults. Design In‐person survey conducted over a 3‐month period 1998; assessment 15‐year follow‐up period. Setting Denmark. Participants All 3,600 Danes born 1905 and living Denmark 1998, were invited to participate regardless residence health; 2,262 (63%) participated the survey: 1,814 (80.2%) person 448 (19.8%) through proxy. Measurements Socioeconomic factors, medications...
Testicular cancer (TC) incidence has increased worldwide, but specific exposures of TC still need investigation. In this cohort study, we investigated the association between mothers' smoking and risk in their sons. was divided into morphological subtype seminoma non-seminomas. Because information about maternal not available study period lung diagnosis used as a proxy for smoking, making it possible 51 years complete follow-up. We nationwide Danish Cancer Registry Civil Registration System...
Background This study compares handgrip strength and its association with mortality across studies conducted in Moscow, Denmark, England. Materials The data collected by the Study of Stress, Aging, Health Russia, Middle-Aged Danish Twins Longitudinal Aging Twins, English Ageing was utilized. Results Among male participants, age-standardized grip 2 kg 1 lower Russia than Denmark England, respectively. among female participants 1.9 1.6 In a one-kilogram increase associated 4% (hazard ratio...
The CLU gene is one of the prime genetic candidates associated with Alzheimers disease. In present study genotypes and haplotypes were baseline cognition rate cognitive decline in two cohorts, Danish 1905 birth cohort (93 years age 1998) Longitudinal Study Aging twins (LSADT) (73–83 year old 1997). Both Mini Mental State Examination (MMSE) a composite score was attained up to six times for 10 analysed using random effects models vital status. rs11136000 T allele better performance both LSADT...
We evaluated which equations best predicted the lung function of a cohort nonagenarians based on accounted for subsequent survival. In 1998, we measured function, grip strength and dementia score (Mini Mental State Examination (MMSE)) in population-based sample 2262 Danes born 1905. Mortality was registered to 2011 when only five (0.2%) subjects were alive. half cohort, recorded forced expiratory volume 1 s (FEV ). Complete data available 592 with results expressed as standardised residuals...
With the continued rise in proportion of oldest-old high-income countries, it is interest to know whether functional health today's oldest-olds better or worse than previous cohorts. Using two Danish centenarian birth cohorts born 20 years apart we aimed at investigating if later cohort had functioning terms activities daily living (ADL). Identification, methodology, and assessment instruments were identical 1895-West 1915-West Birth Cohort Studies: All persons western part Denmark turning...
Alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) are widely used markers of liver disease. Several population-based cohort studies have found associations these enzymes with all-cause mortality. None controlled for genetic variation as well fetal early life exposure, whether environmental or genetic.We studied the ALT GGT mortality using data 686 twins (73-94 years old) included in Longitudinal Study Aging Danish Twins.An increase 1 logged U/L was associated a 15% hazard...
Objectives-Little is known about whether the feeling of happiness follows age-related decline in physical and mental functioning.The objective this study was to analyze differences with age functions among Danes aged 45 years older.Method-Three Danish population-based surveys including 11,307 participants 45+ years, whom 2411 were group 90+, conducted period 1995-2001.The participation rate three between 63% 82% same design instrument used.Self-reported mobility, a cognitive composite score,...
Abstract Background Little is known about the impact of pain on physical functioning among oldest‐old subjects. In this study, we first examined associations between number painful sites and measures reflecting different stages disablement process (physical impairment, functional limitation disability) nonagenarians (more than ninety years old persons). Second, described effect disability during a 2‐year follow‐up period. Methods This study based baseline ( n = 1177) 709) data nationwide D...