A5058330327- TGF-β signaling in diseases
- Network Traffic and Congestion Control
- Advanced Wireless Network Optimization
- Heme Oxygenase-1 and Carbon Monoxide
- Software-Defined Networks and 5G
- Engineering Applied Research
- Internet of Things and Social Network Interactions
- NF-κB Signaling Pathways
- Manufacturing Process and Optimization
- Genomics, phytochemicals, and oxidative stress
- Advanced Optical Network Technologies
- Cell death mechanisms and regulation
- Advanced Welding Techniques Analysis
- Radiomics and Machine Learning in Medical Imaging
- Energy and Environmental Systems
- Advanced MIMO Systems Optimization
- Microwave Engineering and Waveguides
- Pancreatic and Hepatic Oncology Research
- Technology and Data Analysis
- Optical Network Technologies
- Eicosanoids and Hypertension Pharmacology
- Mobile Agent-Based Network Management
- Energy Efficient Wireless Sensor Networks
- Alcohol Consumption and Health Effects
- Mesenchymal stem cell research
University of Maryland, College Park
2024
Daewoo Shipbuilding and Marine Engineering (South Korea)
2024
Korea Institute of Radiological and Medical Sciences
2020-2023
Seoul National University
2017-2021
Kangwon National University
2009-2020
Chungnam National University
2011-2020
Australian Regenerative Medicine Institute
2018
Monash University
2018
Ministry of Food and Drug Safety
2016
Baekseok University
2014-2015
Kaempferol, a natural dietary flavonoid, is well known to possess chemopreventive and therapeutic anticancer efficacy; however, its antimetastatic effects have not been mechanistically studied so far in any cancer model. This study was aimed investigate the inhibitory effect accompanying mechanisms of kaempferol on epithelial-to-mesenchymal transition (EMT) cell migration induced by transforming growth factor-β1 (TGF-β1). In human A549 non-small lung cells, strongly blocked enhancement...
For many URLLC services, mobility is a key requirement together with latency and reliability. 3GPP has defined the target of MIT as 0 ms, general reliability 1 - 10-5 within ms for 5G. In this article, we analyzed impact handover failure (HOF) rate on performance. From analysis, at 120 km/h, required HOF to achieve 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-5</sup> only 0.52 percent. Therefore, URLLC, need minimize not but also close...
Smad7 inhibits responses mediated by transforming growth factor beta (TGF-beta) and acts in a negative-feedback loop to regulate the intensity or duration of TGF-beta signal. However, aberrant expression continued presence may cause resistance. Here we report that Jab1/CSN5, which is component COP9 signalosome complex, associates constitutively with overexpression Jab1/CSN5 causes translocation from nucleus cytoplasm, promoting its degradation. Overexpression increases Smad2 phosphorylation...
Transforming growth factor β (TGF-β) induces apoptosis in a variety of cells. We have previously shown that TGF-β1 rapidly the FaO rat hepatoma cell line. now studied effect on expression different members Bcl-2 family these observed no detectable changes steady-state levels Bcl-2, Bcl-XL, and Bax. However, induced caspase-dependent cleavage BAD at its N terminus to generate 15-kDa truncated protein. Overexpression protein enhanced TGF-β1-induced apoptosis, whereas mutant resistant caspase 3...
Design criteria and analysis procedures for a practical OFDM underwater communications system are presented. A new broadband channel model with Doppler time scaling effect is developed. two-dimensional MMSE scheme using frequency pilots employed estimation. shift estimated cyclic prefix compensated by digital sampling rate conversion procedure. Numerical simulations demonstrate that the technique robust respect to selectivity selectivity.
The human papillomavirus (HPV) oncoprotein E7 is implicated in the etiology of cervical cancer associated with infection by HPV. HPV-positive cells develop resistance to TGF-β growth inhibitory activity through inhibition hypophosphorylation pRb type 16 oncoprotein. In this study, we examined whether E7, addition its well known effects on pRb, might directly target Smad proteins that mediate signaling. Here, show significantly blocks both transcriptional and ability inhibit DNA synthesis. We...
Although transforming growth factor β1 (TGF-β1) acts via the Smad signaling pathway to initiate de novo gene transcription, TGF-β1-induced MAPK kinase activation that is involved in regulation of apoptosis less well understood. Even though p38 MAP and c-Jun NH2-terminal kinases (JNKs) are cell death hepatoma cells, upstream mediators these remain be defined. We show here members mixed lineage (MLK) family (including MLK1, MLK2, MLK3, dual leucine zipper-bearing (DLK)) expressed FaO rat cells...
The human T-cell lymphotropic virus type 1 (HTLV-1) oncoprotein Tax is implicated in various clinical manifestations associated with infection by HTLV-1, including an aggressive and fatal malignancy. Because many HTLV-1-infected lines are resistant to the growth inhibitory activity of transforming factor β (TGF-β), we examined possibility that HTVL-1-Tax regulates TGF-β signaling. We show significantly decreases transcriptional inhibition response TGF-β. inhibits TGF-β-induced plasminogen...
Transforming growth factor (TGF) β1 is a potent inducer of apoptosis in the liver. During TGF-β1-induced apoptosis, 3 mitogen-activated protein (MAP) kinases (extracellular signal-regulated kinase [ERK], c-Jun N -terminal [JNK], and p38 kinase) showed simultaneously sustained activation FaO rat hepatoma cells. was markedly enhanced when ERK selectively inhibited by kinase/extracellular inhibitor PD98059. In contrast, both interfering with activity overexpression dominant negative (DN) MKK6...
We investigated the signaling pathway that leads to expression of heme oxygenase‐1 (HO‐1) in murine macrophages response 15‐deoxy‐Δ 12,14 ‐prostaglandin J 2 (15dPGJ ). 15dPGJ caused dose‐ and time‐dependent activation Rac1, followed by a transient increase reactive oxygen species (ROS) via NADPH oxidase, which downstream p38 kinase. Inhibition ‐dependent HO‐1 significantly attenuated suppression LPS‐induced iNOS subsequent production nitric oxide (NO). Our findings strongly suggest exerts...
The dissimilar Al alloys, 5052 and 5J32, were joined by friction stir welding (FSW) technique under several conditions, including material arrangement. tool rotation speeds 1000 1500 rpm, the varied within range from 100 to 400 mm/min. At a speed of all joints with on advancing side exhibited better properties than those opposite When 5J32 was placed side, defect-free welds obtained conditions. However, when retreating some defects detected below top surface side. Furthermore, fractographs...