A5007383554- Analytical Chemistry and Chromatography
- Analytical chemistry methods development
- Nanoparticle-Based Drug Delivery
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Monoclonal and Polyclonal Antibodies Research
- Toxin Mechanisms and Immunotoxins
- Curcumin's Biomedical Applications
- Inorganic and Organometallic Chemistry
- Proteins in Food Systems
- HER2/EGFR in Cancer Research
- RNA Interference and Gene Delivery
- Advanced Drug Delivery Systems
- Mass Spectrometry Techniques and Applications
- Advanced MRI Techniques and Applications
- Protein purification and stability
- Hydrogels: synthesis, properties, applications
- Advanced Polymer Synthesis and Characterization
- Ubiquitin and proteasome pathways
- Molecular Sensors and Ion Detection
- Immunotherapy and Immune Responses
- Dendrimers and Hyperbranched Polymers
- Blood disorders and treatments
- NMR spectroscopy and applications
- Immunodeficiency and Autoimmune Disorders
Center for Global Development
2024
Sanofi (United States)
2018-2023
Sanofi (France)
2020
SynZyme Technologies (United States)
2011
Eloxx Pharmaceuticals (United States)
2001
University of Massachusetts Lowell
1998
California Institute of Technology
1994
Indian Institute of Technology Bombay
1985-1989
Heinrich Heine University Düsseldorf
1989
Indian Agricultural Research Institute
1971
Gasdermin B (GSDMB) overexpression/amplification occurs in about 60% of HER2 breast cancers, where it promotes cell migration, resistance to anti-HER2 therapies, and poor clinical outcome. Thus, we tackle GSDMB cytoplasmic overexpression as a new therapeutic target cancers.We have developed targeted nanomedicine based on hyaluronic acid-biocompatible nanocapsules, which allow the intracellular delivery specific anti-GSDMB antibody into cancer cells both vitro vivo.Using different models...
Bovine milk-derived exosomes have recently emerged as a promising nano-vehicle for the encapsulation and delivery of macromolecular biotherapeutics. Here we engineer high purity bovine milk (mExo) with modular surface tunability oral small interfering RNA (siRNA). We utilize low-cost enrichment method combining casein chelation differential ultracentrifugation followed by size exclusion chromatography, yielding mExo concentration purity. Using in vitro models, demonstrate that negatively...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTemplate-mediated synthesis of metal-complexing polymers for molecular recognitionPradeep K. Dhal and Frances H. ArnoldCite this: J. Am. Chem. Soc. 1991, 113, 19, 7417–7418Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September 1991https://pubs.acs.org/doi/10.1021/ja00019a046https://doi.org/10.1021/ja00019a046research-articleACS PublicationsRequest reuse permissionsArticle...
Abstract A growing global health concern, Lyme disease has become the most common tick-borne in United States and Europe. Caused by bacterial spirochete Borrelia burgdorferi sensu lato (sl), this can be debilitating if not treated promptly. Because diagnosis is challenging, prevention remains a priority; however, previously licensed vaccine no longer available to public. Here, we designed six component that elicits antibody (Ab) responses against all strains commonly cause humans. The outer...
Abstract Preparation of sophisticated delivery systems for nanomedicine applications generally involve multi-step procedures using organic solvents. In this study, we have developed a simple self-assembling process to prepare docetaxel-loaded hyaluronic acid (HA) nanocapsules by self-emulsification without the need solvents, heat or high shear forces. These nanocapsules, which comprise an oily core and shell consisting assembly surfactants hydrophobically modified HA, mean size 130 nm, zeta...
Abstract Molecularly imprinted polymers (MIPs) are tailor‐made synthetic antibodies possessing specific binding cavities designed for a target molecule. Currently, MIPs protein targets synthesized by imprinting short surface‐exposed fragment of the protein, called epitope or antigenic determinant. However, finding par excellence that will yield peptide “synthetic antibody” cross‐reacting exclusively with from which it is derived, not easy. We propose computer‐based rational approach to...
Tumor Necrosis Factor-α (TNF-α) is a cytokine that normally produced by immune cells when fighting an infection. But, too much TNF-α as in autoimmune diseases, this leads to unwanted and persistent inflammation. Anti-TNF-α monoclonal antibodies have revolutionized the therapy of these disorders blocking preventing its binding receptors, thus suppressing Herein, we propose alternative form molecularly imprinted polymer nanogels (MIP-NGs). MIP-NGs are synthetic obtained nanomoulding...
ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication the EditorNEXTNovel Cholesterol Lowering Polymeric Drugs Obtained by Molecular ImprintingChad C. Huval, Mathew J. Bailey, William H. Braunlin, S. Randall Holmes-Farley, W. Harry Mandeville, John Petersen, Steven Polomoscanik, Robert Sacchiro, Xi Chen, and Pradeep K. DhalView Author Information GelTex Pharmaceuticals, Inc., 153 Second Avenue, Waltham, Massachusetts 02451 Cite this: Macromolecules 2001, 34, 6,...
Exosomes have emerged as a promising tool for the delivery of drugs and genetic materials, owing to their biocompatibility non-immunogenic nature. However, challenges persist in achieving successful oral due susceptibility degradation harsh gastrointestinal (GI) environment impeded transport across mucus-epithelium barrier. To overcome these challenges, we developed high-purity bovine milk exosomes (mExo) scalable efficient drug system, which can be customized by incorporating hydrophilic...
We report a modular approach to synthesize maleimido group containing hydrophilic dolastatin 10 (Dol10) derivatives as drug-linkers for the syntheses of antibody-drug conjugates (ADCs). Discrete polyethylene glycol (PEG) moieties different chain lengths were introduced part linker impart hydrophilicity these drug linkers. The synthesis process involved construction PEG tetrapeptide intermediate (N-methylvaline-valine-dolaisoleucine-dolaproine), which subsequently coupled with dolaphenine...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMicrostructure elucidation of glycidyl methacrylate-alkyl acrylate copolymers by carbon-13 NMR spectroscopyPradeep K. Dhal, G. N. Babu, and R. NandaCite this: Macromolecules 1984, 17, 6, 1131–1135Publication Date (Print):June 1, 1984Publication History Published online1 May 2002Published inissue 1 June 1984https://pubs.acs.org/doi/10.1021/ma00136a004https://doi.org/10.1021/ma00136a004research-articleACS PublicationsRequest reuse permissionsArticle...
Polymerization of 4-vinylbenzoic acid in the presence C60 using free radical initiator resulted covalent incorporation polymer structure. Incorporation moieties was established by IR, NMR, and UV−vis spectroscopy. The solution spectra these C60-containing copolymers appear to be dominated scattering, obscuring specific electronic excitation features associated with fullerene. spectral analysis filtrate fractions collected filters varying pore sizes indicates that polymers form microgels...
Syntheses and characterization of aminooxy terminated polymers N-(2-hydroxyproyl) methacrylamide (HPMA) controlled molecular weight narrow distribution are presented here. Design a chain transfer agent (CTA) containing N-tert-butoxycarbonyl (t-Boc) protected group enabled us to use reversible addition-fragmentation (RAFT) polymerization technique polymerize the HPMA monomer. An amide bond was utilized link CTA through triethylene glycol spacer. As result, is linked poly(HPMA) backbone...
Hyaluronic acid (HA) microgels were investigated as biocompatible and biodegradable reagents for facilitating endosomolysis in human cells. Employing inverse emulsion templates, HA prepared by cross-linking aqueous sodium hyaluronate droplets with divinyl sulfone (DVS). Introduction of ether cross-links was confirmed infrared (IR) spectroscopy elemental analysis. The degree the estimated using high performance liquid chromatography (HPLC). size distribution water-dispersible studied laser...
As a gut-restricted, nonabsorbed therapy, polymeric bile acid sequestrants (BAS) play an important role in managing hyperlipidemia and hyperglycemia. Similarly, nonabsorbable of dietary phosphate have been used for the management hyperphosphatemia end-stage renal disease. To evaluate potential utility such polymer to treat type 2 diabetes (T2D) its associated cardiovascular complications, we synthesized novel sequestrant, SAR442357, possessing optimized (BA) sequestration characteristics....
Abstract Tumor Necrosis Factor‐α (TNF‐α) is a cytokine that normally produced by immune cells when fighting an infection. But, too much TNF‐α as in autoimmune diseases, this leads to unwanted and persistent inflammation. Anti‐TNF‐α monoclonal antibodies have revolutionized the therapy of these disorders blocking preventing its binding receptors, thus suppressing Herein, we propose alternative form molecularly imprinted polymer nanogels (MIP‐NGs). MIP‐NGs are synthetic obtained nanomoulding...
Abstract A series of novel multivalent drug linkers (MDLs) containing cytotoxic agents were synthesized and conjugated to antibodies yield highly potent antibody–drug conjugates (ADCs) with drug/antibody ratios (DARs) higher than those typically reported in the literature (10 vs. ≈4). These MDLs contain two copies a agent attached biocompatible scaffolds composed branched peptide core discrete polyethylene glycol (PEG) chains enhance solubility decrease aggregation. produced well‐defined...
Abstract The affinity chromatographic characteristics of some chemically modified copolymers based on glycidyl methacrylate have been evaluated. were by means reaction suitable ligands with epoxy groups. Purification pencillin acylase was carried out using these matrices as the stationary phase in column. Effect nature and pH binding desorption efficiency enzyme