A5039010117- Neuroscience and Neuropharmacology Research
- Plant Virus Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Plant Pathogenic Bacteria Studies
- Plant and Fungal Interactions Research
- Plant Disease Resistance and Genetics
- Tryptophan and brain disorders
- Ion channel regulation and function
- Memory and Neural Mechanisms
- Cardiac electrophysiology and arrhythmias
- Stress Responses and Cortisol
- Autism Spectrum Disorder Research
- Alzheimer's disease research and treatments
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Neural dynamics and brain function
- S100 Proteins and Annexins
- Genetics and Neurodevelopmental Disorders
- Barrier Structure and Function Studies
- Cellular transport and secretion
- Viral Infections and Immunology Research
- Insect-Plant Interactions and Control
Yale University
2021-2025
University of Chicago
2017
University of Kentucky
2017
University of Auckland
2012-2014
SARS-CoV-2 is the cause of a pandemic with growing global mortality. Using comprehensive identification RNA-binding proteins by mass spectrometry (ChIRP-MS), we identified 309 host that bind RNA during active infection. Integration this data ChIRP-MS from three other viruses defined viral specificity RNA-host protein interactions. Targeted CRISPR screens revealed majority functional protect virus-induced cell death, and comparative across seven shared SARS-specific antiviral factors....
Importance The risk of mental disorders is consistently associated with variants in CACNA1C (L-type calcium channel Cav1.2) but it not known why these channels are critical to cognition, and whether they affect the layer III pyramidal cells dorsolateral prefrontal cortex that especially vulnerable cognitive disorders. Objective To examine molecular mechanisms expressed primate cortices. Design, Setting, Participants design included transcriptomic analyses from human macaque cortex,...
Glutamate carboxypeptidase-II (GCPII) expression in brain is increased by inflammation, e.g. COVID19 infection, where it reduces NAAG stimulation of metabotropic glutamate receptor type 3 (mGluR3). GCPII-mGluR3 signaling increasingly linked to higher cognition, as genetic alterations that weaken mGluR3 or increase GCPII are associated with impaired cognition humans. Recent evidence from macaque dorsolateral prefrontal cortex (dlPFC) shows expressed on dendritic spines, they regulate cAMP-PKA...
Abstract Background The newly evolved dorsolateral prefrontal cortex (dlPFC) with pyramidal cell circuits in layer 3 are essential to higher cognition1,2. However, these cells uniquely susceptible psychiatric disorders, where is the focus of synapse dendritic atrophy schizophrenia and degenerative disorders such as Alzheimer’ s disease (AD), correlating degree cognitive deficits3-6. In particular, mutations CACNA1C (L-type-calcium-channel Cav1.2) consistently linked increased risk mental but...
Metabotropic glutamate receptors type 3 (mGlu3, encoded by GRM3) are increasingly related to cognitive functioning, including the working memory operations of prefrontal cortex (PFC). In rhesus monkeys, mGlu3 most commonly expressed on glia (36%), but also very prominent layer III dendritic spines (23%) in dorsolateral PFC (dlPFC) where they enhance memory-related neuronal firing. contrast, mGlu2 predominately presynaptic macaque dlPFC, indicating a pre- vs. post-synaptic dissociation...
Glutamate carboxypeptidase II (GCPII) expression in brain is increased by inflammation, and reduces NAAG (N-acetyl aspartyl glutamate) stimulation of mGluR3 signaling. Genetic insults this signaling cascade are increasingly linked to cognitive disorders humans, where GCPII or decreased NAAG-mGluR3 associated with impaired prefrontal cortical (PFC) activation impairment. As aging inflammation PFC deficits, the current study examined rat medial PFC, tested whether inhibition...
BIN1 is the second most significant Alzheimer's disease (AD) risk factor gene identified through genome-wide association studies. an adaptor protein that can bind to several proteins including c-Myc, clathrin, protein-2 and dynamin. widely expressed in brain peripheral tissue as ubiquitous tissue-specific alternatively spliced isoforms regulate membrane dynamics endocytosis multiple cell types. The function of mechanism(s) by which AD-associated alleles increase for are not known. has been...
Summary Cognitive deficits from dorsolateral prefrontal cortex (dlPFC) dysfunction are common in neuroinflammatory disorders, including long-COVID, schizophrenia and Alzheimer’s disease, have been correlated with kynurenine inflammatory signaling. Kynurenine is further metabolized to kynurenic acid (KYNA) brain, where it blocks NMDA α7-nicotinic receptors (nic-α7Rs). These essential for neurotransmission dlPFC, suggesting that KYNA may cause higher cognitive these disorders. The current...
Cherry leaf roll virus ( CLRV ) isolates from M alus domestica , R ibes rubrum ubus idaeus umex obtusifolius and V accinium darrowii were characterized based on nucleotide sequences of a 371 bp fragment the 3′ untranslated region UTR their genomic RNA s, symptoms in herbaceous hosts, C henopodium amaranticolor quinoa N icotiana benthamiana occidentalis tabacum seed transmission . The different induced range localized systemic disease symptoms, varying severity, hosts. all showed greater than...
Abstract S trawberry latent ringspot virus ( SLRSV ) was detected in blueberry V accinium darrowii ), a host not previously reported. A total of 89 samples were obtained from one site the N orth I sland ew Z ealand and tested by reverse transcription—polymerase chain reaction RT ‐ PCR assay. Both sequencing results showed presence four samples. Although is known to have wide range, this appears be first report blueberry.
Cherry leaf roll virus (CLRV) is a member of the genus Nepovirus, family Secoviridae (Sanfaçon et al., 3) and has wide host range geographical distribution. CLRV was first described in 1933 Persian English walnut (Juglans regia). subsequently been found to have diverse that includes trees (American elm, ash, birch, beech), horticulturally significant species (apple, blackberry, grapevine, olive, raspberry, rhubarb, sweet cherry) number shrub, weed ornamental species. recorded from Europe,...
Genetic variations in L-type-calcium-channels (LTCC) Cav1.2 (CACNA1C) are frequently associated with stress-related cognitive disorders. Here we examined Cav1.2-LTCC actions macaque dorsolateral prefrontal cortical (dlPFC) NMDAR-GluN2B circuits that mediate cognition. LTCCs were essential for working memory-related neuronal firing. However, high LTCC calcium influx, driven by β1-adrenoceptors (β1-ARs) -similar to the stress response heart- reduced firing via SK channel opening. Likewise,...