A5057948319- Carcinogens and Genotoxicity Assessment
- Trace Elements in Health
- Iron Metabolism and Disorders
- Natural product bioactivities and synthesis
- Environmental Toxicology and Ecotoxicology
- Toxic Organic Pollutants Impact
- Plant Micronutrient Interactions and Effects
- Phytochemical compounds biological activities
- Liver Disease Diagnosis and Treatment
- Chemical Reactions and Isotopes
- Phytochemistry and Biological Activities
- Edible Oils Quality and Analysis
- Plant-Derived Bioactive Compounds
- Pharmaceutical and Antibiotic Environmental Impacts
- Antioxidant Activity and Oxidative Stress
- Pesticide Exposure and Toxicity
- Vitamin C and Antioxidants Research
- Coconut Research and Applications
- Mass Spectrometry Techniques and Applications
- Phytochemicals and Antioxidant Activities
Sefako Makgatho Health Sciences University
2005-2009
University of Limpopo
2004-2009
Seoul National University
2004
The University of Texas Medical Branch at Galveston
1989-1990
University of Liège
1979
Although excess hepatic iron in hereditary haemochromatosis and dietary overload the African causes hepatocellular carcinoma, it usually does so presence of cirrhosis. A direct hepatocarcinogenic effect has not been proved. Moreover, an animal model carcinoma induced by available. The aim this study was to develop such a use ascertain whether is directly hepatocarcinogenic. Sixty Wistar albino rats were fed chow diet 60 same supplemented initially with 2% carbonyl for 12 months, followed...
Abstract Cancer bush (CB, Sutherlandia frutescens), Devil's claw (DEV, Harpagophytum procumbens), Rooibos tea (RT, Aspalathus linearis), and Bambara groundnut (BB, Vignea subterranean) have been used to treat some malignancies inflammatory disorders in Africa. However, biochemical basis for chemopreventive effects of these medicinal plants remains unclear. An abnormally elevated expression cyclooxygenase‐2 (COX‐2) has implicated pathogenesis progression carcinogenesis. In the present study,...
In dietary iron overload, excess hepatic promotes liver damage. The aim was to attenuate free radical-induced damage using vitamins. Four groups of 60 Wistar rats were studied: group 1 (control) fed normal diet, 2 (Fe) 2.5% pentacarbonyl (CI) followed by 0.5% Ferrocene, 3 (Fe + V gp) CI, plus vitamins A and E (42× 10× RDA, respectively), 4 – Ferrocene minus E. At 20 months, glutathione peroxidase (GPx), superoxide dismutase (SOD), Oxygen Radical Absorbance Capacity (ORAC), Ames mutagenicity...
Abstract In bioassays conducted under controlled, comparable conditions, weak direct mutagenicity responses were observed for hydrogen peroxide in the standard (Ames test) agar plate incorporation bioassay with Salmonella typhimurium strains TA97, TA98, TA102, and TA1537, a 20 min preincubation test TA100, TA1538, liquid incubation modification using strain TA1537. These results conclusively demonstrate that is mutagen, especially are sensitive to oxidative damage suitable conditions.
Abstract Weak mutagenic activity was detected in several commercially available edible palm and corn oils using liquid incubation bioassays with Salmonella typhimurium TA1537. Chromatographic fractionation of unrefined oil established that present three fractions also contained fatty acyl hydroperoxides. Similar weak demonstrated for linoleic linolenic acid In all cases, the mutagenicity abolished by exogenous catalase, implying observed moderated hydrogen peroxide.